Original Article
immunology & Biochemistry
Mohammad Shafi Mojadadi; Maryam Amirpour; Mohammad Sahebkar; Maryam Karrabi; saeideh sadat shobeiri
Abstract
Background: Psoriasis is a common skin disease that presents with papulosquamous lesions (scaly papules and plaques) and can have psychological and physical consequences. Due to the anti-inflammatory role of vitamin D, studies have been conducted on the relationship between serum levels of this vitamin ...
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Background: Psoriasis is a common skin disease that presents with papulosquamous lesions (scaly papules and plaques) and can have psychological and physical consequences. Due to the anti-inflammatory role of vitamin D, studies have been conducted on the relationship between serum levels of this vitamin and psoriasis. In recent years, conflicting results have been obtained, all of which emphasize the importance of investigating this issue. This study aimed to investigate the relationship between serum 25-hydroxy-vitamin D levels and psoriasis.Methods: We conducted a case-control study with psoriasis patients from Vasei Hospital's dermatology clinic and healthy people from Sabzevar Blood Transfusion Center in Iran. Patients with chronic psoriasis (more than 6 months) aged 18 to 65 years were included in the study regardless of the type of psoriasis. This study had a sample size of 177 people (88 cases, and 89 controls). The data collection methods were a questionnaire and blood samples. In both groups, the amount of 25-hydroxy-vitamin D was measured by ELISA method.Results: This study recruited 177 individuals: 78 (44.10%) males and 99 (55.90%) females. The mean age in the case group was 36.95±13.30 and in the control group was 21.34±12.60 years. The mean vitamin D levels had not significant difference between case (19.68±13.60) and control groups (21.34±12.60) (P>0.05).Conclusion: The findings of this study showed that there was no significant difference in vitamin D levels between the case group and the control group, which did not support the hypothesis that vitamin D deficiency is associated with psoriasis.
Original Article
Mohammad solimani farsani; mohammad fathi; zahra hemati; zinab gorgin
Abstract
Introduction: Exercise is a non-drug option to prevent or slow the progression of Alzheimer's. Therefore, this research seeks to find the possible mechanism of the connection between muscle and hippocampus..
Materials and methods: 32 6-week-old rats were randomly divided into four groups: sham (SH), ...
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Introduction: Exercise is a non-drug option to prevent or slow the progression of Alzheimer's. Therefore, this research seeks to find the possible mechanism of the connection between muscle and hippocampus..
Materials and methods: 32 6-week-old rats were randomly divided into four groups: sham (SH), Alzheimer's control (AC), training (T) and Alzheimer's training (AT). Alzheimer's was induced by injecting beta-amyloid into the hippocampus. The training program consisted of 20 swimming training sessions with increasing time. After the end of the intervention, the tissue of the Gastrocnemius muscle and hippocampus was removed and the expression of the desired proteins was measured by immunohistofluorescent staining method. Correlation test was used to check the changes of the studied indicators.
Findings: The results showed that the expression of NCAM, SEMA3A and Pfn1 proteins had a significant positive relationship with NACHRa7 (P=0.001) and a significant inverse relationship with NLRP1 (P≥0.05) and Dead Cells (P≥0.05). they had.
Conclusion: Hippocampal inflammation and Alzheimer's progression can be prevented by physical activity and strengthening the neuromuscular junction.
Original Article
Psychology
Hosein Fahimi; samira foji; elham navipour; Milad Maleki
Abstract
Background and objective: Olanzapine is one of the antipsychotic drugs for the treatment of schizophrenia, but it has been noticed due to significant metabolic adverse effects, including the highest weight gain among all antipsychotic drugs.
Materials and methods: This study was conducted as a clinical ...
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Background and objective: Olanzapine is one of the antipsychotic drugs for the treatment of schizophrenia, but it has been noticed due to significant metabolic adverse effects, including the highest weight gain among all antipsychotic drugs.
Materials and methods: This study was conducted as a clinical trial on 120 patients with psychosis under standard treatment with olanzapine. The weight and waist circumference of both groups were measured before and after the study, and the effect of betahistine on the intervention group was compared to the control group. The study data were transformed using SPSS version 24 software and using statistical methods of analysis.
findings:
. The weight before the intervention in the control group was 66.3±10.88, and after the intervention it was 69.67±13.03, and in the intervention group, before the start of the study, it was 66.45±9.95 and after the intervention, it was 11.20. Waist circumference 68.16 ± 70.06 cm ± 12.63 ± 12.63 cm before the intervention in the control group and 71.55 ± 13.13 cm after the intervention and in the intervention group the waist circumference was 11.80 ± 11.80 cm. ± 68.26 cm and after the end of the intervention, 69.4 ± 12.70 cm was obtained.
Conclusion: At the same time as weight gain, olanzapine is prevented in the intervention group and there was no method to prevent weight gain caused by olanzapine.
Original Article
Physical Education
mitra khademosharie; azam mollanovruzi
Abstract
Background and Purpose: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing type two of diabetes. Gestational diabetes can cause various complications for the mother and fetus. Therefore, the aim of this ...
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Background and Purpose: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing type two of diabetes. Gestational diabetes can cause various complications for the mother and fetus. Therefore, the aim of this study was to investigate the effect of 12 weeks of combined training on the levels of some adipokines in women with gestational diabetes.
Method:
For this purpose, among pregnant women aged 25 to 35 years with gestational diabetes and gestational age of 23 to 24 weeks, 28 people were voluntarily selected to conduct the research and randomly divided into two groups, the experimental group (14 people). and control (14 people). The combined exercise training program was as follows in 12 weeks, three training sessions each week. Measurements and blood tests were performed 24 hours before the start of training and 24 hours after the last training session. In order to analyze the data, ANOVA test with repeated measures (repeated measure ANOVA) was used. The significance level was considered as p≤0.05 and the data was analyzed using SPSS version 23 software.
Results: 12 weeks of combined exercise training caused a significant increase in the hormone adiponectin (P=0.001) and a significant decrease in the hormone visfatin (P=0.001) in the experimental group.
Conclusion: The results of the above research showed that women with gestational diabetes can benefit from many Advantages, including the improvement of adiponectin and visfatin secreted from fat tissue, with correct and principled exercise training.
Original Article
Biotechnology & nanotechnology
Mahta Majdnia; Maryam Sadrnia; Fatemeh Shahbazi; Nooshin Sohrabi
Abstract
Introduction: One of the best ways to remove toxic metals is to use bacteria resistant to these metals with biological purification process. The aim of this research is to isolate bacteria resistant to tin, copper, chromium and nickel from industrial wastewater and their molecular identification.
Materials ...
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Introduction: One of the best ways to remove toxic metals is to use bacteria resistant to these metals with biological purification process. The aim of this research is to isolate bacteria resistant to tin, copper, chromium and nickel from industrial wastewater and their molecular identification.
Materials and methods: First, wastewater contaminated with heavy metals was collected from electroplating factories located in Tehran province. The wastewater sample was cultured on LB Agar containing certain concentrations of heavy metals and the grown bacteria were isolated. On the grown bacteria, the minimum growth inhibitory concentration (MIC) of heavy metals was determined by the microbroth dilution method. Genomic DNA of two strains with the highest level of resistance, purity and polymerase chain reaction was performed with the help of specific primers. The PCR product was sequenced and ribotyping was done.
Results: 9 gram positive and negative bacilli and gram negative coccobacilli were isolated from wastewater containing heavy metals. Two Gram-negative bacillus strains showed the highest resistance to heavy metals in the MIC test. Based on the sequencing results, these two strains were identified as Enterobacter and Pseudomonas.
Conclusion: Two strains with the highest resistance to four metals were isolated from the effluent of electroplating factories and phylogenetic evaluation was performed. These bacteria can be used in the biological treatment of wastewater containing heavy metals.
Original Article
Psychology
Fatemeh Azizi Ganjehei; Isaac Rahimian Boogar
Abstract
Background: Adjustment disorder is one of the most common psychiatric disorders, and it is important to determine the factors involved in it. This study investigated the predictive role of individual, social, and psychological determinants in adjustment disorder.
Materials and Methods: The current research ...
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Background: Adjustment disorder is one of the most common psychiatric disorders, and it is important to determine the factors involved in it. This study investigated the predictive role of individual, social, and psychological determinants in adjustment disorder.
Materials and Methods: The current research design is descriptive and correlational. The statistical population of the research includes 402 people living in Tehran, who were selected through the convenience sampling method. Data were collected using the International Adjustment Disorder Questionnaire (IADQ), Death Anxiety Scale (DAS), Fear of Covid-19 Scale (FCV-19S), Multidimensional Perceived Social Support Scale (MSPSS) and the Connor-Davidson Resilience scale (CD-RISC) was collected and analyzed using SPSS-26 software with multiple linear regression analysis in a stepwise method.
Results: The results of the correlation test showed a significant relationship between predicting variables of fear of infected by Covid-19, perceived social support, resilience, and marital status with adjustment disorder, and the results of multiple linear regression showed that adjustment disorder was explained by the highest contribution of resilience variables (0.220). β=-, P=0.000), perceived social support (β=-0.153, P=0.003), fear of infected by Corona (β=0.150, P=0.002) and status Marriage was (β=0.109, P=0.031).
Conclusion: Resilience, perceived social support, fear of infected by COVID-19 and marital status play a role in adjustment disorder and can explain the variability of adjustment disorder. As a result, it seems important to consider these variables in people with adjustment disorder.
Original Article
genetics
Akram Rahimi-Moghaddam; Nassim Ghorbanmehr; Sedigheh Gharbi; Fatemeh Nili
Abstract
Background: The most common cause of cervical cancer is human papillomavirus, which induces its carcinogenic properties on cells through two oncoproteins named E6 and E7. Viral miRNA and oncogenes can alter the expression levels of human miRNAs and genes. Examining the expression profile of miRNAs and ...
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Background: The most common cause of cervical cancer is human papillomavirus, which induces its carcinogenic properties on cells through two oncoproteins named E6 and E7. Viral miRNA and oncogenes can alter the expression levels of human miRNAs and genes. Examining the expression profile of miRNAs and their target genes in cervical cancer leads to the identification of miRNAs and genes that can be used as diagnostic biomarkers or therapeutic targets. MAP9 is one of the predicted targets of HPV16-miR-H2-1. In this study, changes in the expression level of MAP9 and a human miRNA regulating MAP9 are investigated in cervical cancer, and their potential as diagnostic biomarkers or therapeutic targets is evaluated.
Materials and methods: After predicting miRNAs regulating MAP9 using miRDB server, one of these miRNA assosiated with squamous cell carcinoma was selected for quantification in clinical samples. Formalin-fixed, paraffin-embedded (FFPE) blocks of cervical tissues from 30 patients with squamous cell carcinoma were used. Deparaffinization, RNA extraction, DNase treatment, and cDNA synthesis were performed for each sample. The expression level of selected miRNA and MAP9 in tumor and normal samples was investigated by Real-Time PCR method. The results were statistically analyzed.
Results: The significant upregulation of hsa-miR-142-5p and downregulation of MAP9 were observed in tumor samples compared with normal tissues. Roc curve analysis showed that hsa-miR-142-5p and MAP9 have high diagnostic capability for cervical cancer (AUC are 0.80 and 0.81 respectively).
Conclusion: hsa-miR-142-5p and MAP9 have the potential to be used as diagnostic biomarkers or therapeutic targets for cervical cancer.
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