Original Article
Psychology
reza salmanipour noghlabary; Alireza Pirkhaefi; gavid peymani; Ali Akbar Foroghi
Abstract
Introduction: Major depressive disorder is concomitant with cognitive deficits and executive function. This study aimed to determine the effectiveness therapeutic reconsolidation process model on executive functions, neuroplasticity, and schemas associated with major depressive disorder in veterans with ...
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Introduction: Major depressive disorder is concomitant with cognitive deficits and executive function. This study aimed to determine the effectiveness therapeutic reconsolidation process model on executive functions, neuroplasticity, and schemas associated with major depressive disorder in veterans with over 25% of nerves.Materials and Methods: The study method was semi-experimental in the form of pre-test, post-test, and 45-day follow-up. Among the 50 nerves veterans above 25%, who had a history of being admitted to Niayesh Hospital in Tehran, 40 people were randomly assigned to the experimental and control groups and underwent intervention for 12 sessions of 90 minutes once a week for 3 months. The research tools were: Beck Depression Questionnaire (1996), Leahy Emotional Schemas (2002), Wisconsin Cards (2008), Stroop Color Test (1935), and Dennis Vanderwaal's Cognitive Flexibility Questionnaire (2010). Data were analyzed using 24spss software.Results: The results of mixed variance analysis with repeated measurement showed that the training of the therapeutic reconsolidation process model was significantly effective on the executive functions, neuroplasticity and emotional schemas of the sample people. This result also lasted in the follow-up phase (P<0.05).Conclusion: the effective therapeutic reconsolidation process model was able to improve executive function, increase neuroplasticity, and compatible emotional schemas and maladaptive schemas in veterans over 25% of nerves by correcting traumatic memory and reducing depressive symptoms.
Original Article
Psychology
Sara Taghizadeh Hir; Mohammad Narimani; Aghajani Seyfollah; Mehriar Nadrmohammadi; Sajjad Basharpoor
Abstract
Introduction: The purpose of this study was to compare the effectiveness of Transcranial Direct Current Brain Stimulation (tDCS) and computer-based cognitive rehabilitation on improving impulsivity in children with attention-deficit/ hyperactivity disorder.
Materials and Methods: The current research ...
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Introduction: The purpose of this study was to compare the effectiveness of Transcranial Direct Current Brain Stimulation (tDCS) and computer-based cognitive rehabilitation on improving impulsivity in children with attention-deficit/ hyperactivity disorder.
Materials and Methods: The current research design was quasi-experimental with pre-test-post-test and control group. 60 children with attention-deficit/ hyperactivity disorder were selected by purposeful sampling and randomly placed in three groups: experiment 1, experiment 2, and control (20 people in each group). Data were collected using Connors Parent Rating Scale (1978), Raven's Progressive Matrices Test (2000), and Barrett's impulsivity questionnaire (1995). The subjects of the first experimental group received Transcranial Direct Brain Stimulation and the second experimental group also received Captain Log's rehabilitation intervention. The control group did not receive any intervention. Data were analyzed with covariance analysis and Bonferroni's post hoc test.
Results: The results showed that experimental groups had lower impulsivity compared with the control group. Also, by controlling the effect of the pre-test in the two experimental groups, there is a significant difference between the two methods of transcranial direct current brain stimulation and computer-based cognitive rehabilitation (P<0.05), and transcranial direct current brain stimulation is more effective in improving the impulsivity in children with attention-deficit/ hyperactivity disorder.
Conclusion: According to the results, it can be said that the intervention of transcranial direct brain stimulation and cognitive rehabilitation was effective in improving impulsivity in children with attention-deficit/ hyperactivity disorder. Therefore, both interventions can be used to improve impulsivity in these children.
Original Article
Psychology
fatemeh dafeian; zahra yousefi
Abstract
Introduction: The aim of the present study was the effectiveness of narrative therapy on meta emotion and reflective functioning among adolescent girls in Isfahan city.
Materials and Methods: The research method was semi-experimental with a pre-test-post-test design with a control group with a 2-month ...
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Introduction: The aim of the present study was the effectiveness of narrative therapy on meta emotion and reflective functioning among adolescent girls in Isfahan city.
Materials and Methods: The research method was semi-experimental with a pre-test-post-test design with a control group with a 2-month follow-up phase. The statistical population included all adolescent girls aged in Isfahan city. 40 people were selected by available sampling and replaced in two experimental and control groups by a simple random method. The research tools were Fonagy's Reflective Functioning questionnaire (2016) and Mitmansgruber's meta-emotion questionnaire (2009). The experimental group gave 8 sessions of 90-minute narrative therapy intervention based on De Manck's (1941) protocol and the control group was on the waiting list. The data were analyzed using SPSS-23 software and at two descriptive (mean and standard deviation) and inferential (variance analysis with repeated measurements) levels (P<0.001).
Results: The mean and standard deviation for the post-test stage of positive meta-emotion were 25.95±3.92 and 19.55±2.9, negative meta-emotion 7.15±2.60 and 13/10±2/91, and reflective functioning in the post-test stage 66±7.23 and 39.16±5.63 in the control group. That the findings showed that mean positive meta-emotion and reflective functioning to the control group had increased significantly and mean negative meta-emotion to the control group had increased decreases (P<0.001).
Conclusion: Based on this, it can be concluded that the narrative therapy method improves the mental health of adolescent girls and improves their cognitive and emotional components.
Original Article
Psychology
Fatemeh Azizi Ganjehei; Isaac Rahimian Boogar
Abstract
Introduction: Adjustment disorder is one of the most common psychiatric disorders, and it is important to determine the factors involved in it. This study investigated the predictive role of individual, social, and psychological determinants in adjustment disorder.Materials and Methods: The current research ...
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Introduction: Adjustment disorder is one of the most common psychiatric disorders, and it is important to determine the factors involved in it. This study investigated the predictive role of individual, social, and psychological determinants in adjustment disorder.Materials and Methods: The current research design is descriptive and correlational. The statistical population of the research includes 402 people living in Tehran, who were selected through the convenience sampling method. Data were collected using the International Adjustment Disorder Questionnaire (IADQ), Death Anxiety Scale (DAS), Fear of Covid-19 Scale (FCV-19S), Multidimensional Perceived Social Support Scale (MSPSS), and the Connor-Davidson Resilience scale (CD-RISC) was collected and analyzed using SPSS-26 software with multiple linear regression analysis in a stepwise method.Results: The results of the correlation test showed a significant relationship between predicting variables of fear of being infected by Covid-19, perceived social support, resilience, and marital status with adjustment disorder, and the results of multiple linear regression showed that adjustment disorder was explained by the highest contribution of resilience variables (0.220). β=-, P=0.000), perceived social support (β=-0.153, P=0.003), fear of infected by Corona (β=0.150, P=0.002) and status Marriage was (β=0.109, P=0.031).Conclusion: Resilience, perceived social support, fear of being infected by COVID-19, and marital status play a role in adjustment disorder and can explain the variability of adjustment disorder. As a result, it seems important to consider these variables in people with adjustment disorder.
Original Article
Biotechnology & nanotechnology
Mahta Majdnia; Maryam Sadrnia; Fatemeh Shahbazi; Nooshin Sohrabi
Abstract
Introduction: One of the best ways to remove toxic metals is to use bacteria resistant to these metals with a biological purification process. This research aims to isolate bacteria resistant to tin, copper, chromium, and nickel from industrial wastewater and their molecular identification.
Materials ...
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Introduction: One of the best ways to remove toxic metals is to use bacteria resistant to these metals with a biological purification process. This research aims to isolate bacteria resistant to tin, copper, chromium, and nickel from industrial wastewater and their molecular identification.
Materials and Methods: wastewater contaminated with heavy metals was collected from electroplating factories located in Tehran province. The wastewater sample was cultured on LB Agar containing certain concentrations of heavy metals and the grown bacteria were isolated. In the grown bacteria, the minimum growth inhibitory concentration (MIC) of heavy metals was determined by the microbroth dilution method. The genomic DNA of two strains with the highest level of resistance, purity, and polymerase chain reaction was performed with the help of specific primers. The PCR product was sequenced and ribotyping was done.
Results: 9 gram-positive and negative bacilli and gram-negative coccobacilli were isolated from wastewater containing heavy metals. Two Gram-negative bacillus strains showed the highest resistance to heavy metals in the MIC test. Based on the sequencing results, these two strains were identified as Enterobacter and Pseudomonas.
Conclusion: Two strains with the highest resistance to four metals were isolated from the effluent of electroplating factories and phylogenetic evaluation was performed. These bacteria can be used in the biological treatment of wastewater containing heavy metals.
Original Article
Psychology
samira foji; Milad Maleki; elham navipour; Hosein Fahimi
Abstract
Introduction: Olanzapine is one of the first-line antipsychotic drugs for schizophrenia and other mental illnesses. This study aims to determine the effect of Betahistine in preventing weight gain through the use of olanzapine in patients with psychosis.Materials and Methods: This study was a clinical ...
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Introduction: Olanzapine is one of the first-line antipsychotic drugs for schizophrenia and other mental illnesses. This study aims to determine the effect of Betahistine in preventing weight gain through the use of olanzapine in patients with psychosis.Materials and Methods: This study was a clinical trial on 120 patients with psychotic disease under standard treatment with olanzapine, after random allocation, 60 people were placed in the intervention and control group. The study data was analyzed using SPSS 24 software and using Wilcoxon and Spearman correlation statistical methods.Results: The average weight before intervention (control) was 66.3 ± 10.88 kg and after the intervention 69.67 ± 13.03. In the intervention group before the start of the study, it was 66.45 ± 9.95 kg, and after the intervention, 68.16±11.20. The average waist circumference before intervention in the control group was 70.06±12.63 cm and after the intervention 71.55±13.13 cm. In the intervention group, the average waist circumference before the study was 68.26 ± 11.80 cm, and after the intervention, it was obtained to be 69.4 ± 12.70. The results showed that in the inter-group comparison, the amount of weight and waist circumference in the two groups were not statistically significant. In the intra-group comparison, an increase in weight and waist circumference in the two groups was observed after the intervention, which was statistically significant.Conclusion: The simultaneous use of Betahistine in the intervention group was not effective in weight loss caused by the use of olanzapine. It is recommended to check other methods of weight control in patients taking olanzapine.
Original Article
genetics
Akram Rahimi-Moghaddam; Nassim Ghorbanmehr; Sedigheh Gharbi; Fatemeh Nili
Abstract
Introduction: The most common cause of cervical cancer is human papillomavirus, which induces its carcinogenic properties on cells through E6 and E7 oncoproteins. Viral miRNA and oncogenes can alter the expression levels of human miRNAs and genes. Examining the expression profile of miRNAs and their ...
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Introduction: The most common cause of cervical cancer is human papillomavirus, which induces its carcinogenic properties on cells through E6 and E7 oncoproteins. Viral miRNA and oncogenes can alter the expression levels of human miRNAs and genes. Examining the expression profile of miRNAs and their target genes in cervical cancer leads to the identification of miRNAs and genes that can be used as diagnostic biomarkers or therapeutic targets. MAP9 is one of the predicted targets of HPV16-miR-H2-1. In this study, changes in the MAP9 expression level and a human miRNA regulating MAP9 were investigated in cervical cancer, and their potential as diagnostic biomarkers or therapeutic targets was evaluated.
Materials and Methods: After predicting miRNAs regulating MAP9 using the miRDB server, one of these miRNAs assosiated with squamous cell carcinoma was selected for quantification in clinical samples. Formalin-fixed, paraffin-embedded blocks of cervical tissue from 30 patients with squamous cell carcinoma were used. Deparaffinization, RNA extraction, DNase treatment, and cDNA synthesis were performed. The expression level of selected miRNA and MAP9 in tumor and normal samples was investigated by the Real-Time PCR method. The results were statistically analyzed.
Results: The significant upregulation of hsa-miR-142-5p and downregulation of MAP9 were observed in tumor samples compared with normal tissues. Roc curve analysis showed that hsa-miR-142-5p and MAP9 have high diagnostic capability for cervical cancer (AUC are 0.80 and 0.81 respectively).
Conclusion: hsa-miR-142-5p and MAP9 have the potential to be used as diagnostic biomarkers or therapeutic targets for cervical cancer.
Original Article
immunology & Biochemistry
Mohammad Shafi Mojadadi; Maryam Amirpour; Mohammad Sahebkar; Maryam Karrabi; saeideh sadat shobeiri
Abstract
Introduction: Psoriasis is a common skin disease that presents with papulosquamous lesions (scaly papules and plaques) and can have psychological and physical consequences. Due to the anti-inflammatory role of vitamin D, studies have been conducted on the relationship between serum levels of this vitamin ...
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Introduction: Psoriasis is a common skin disease that presents with papulosquamous lesions (scaly papules and plaques) and can have psychological and physical consequences. Due to the anti-inflammatory role of vitamin D, studies have been conducted on the relationship between serum levels of this vitamin and psoriasis. In recent years, conflicting results have been obtained, all of which emphasize the importance of investigating this issue. This study aimed to investigate the relationship between serum 25-hydroxy-vitamin D levels and psoriasis.
Materials and Methods: We conducted a case-control study with psoriasis patients from Vasei Hospital's dermatology clinic and healthy people from Sabzevar Blood Transfusion Center in Iran. Patients with chronic psoriasis (more than 6 months) aged 18 to 65 years were included in the study regardless of the type of psoriasis. This study had a sample size of 177 people (88 cases, and 89 controls). The data collection methods were a questionnaire and blood samples. In both groups, the amount of 25-hydroxy-vitamin D was measured by ELISA method.
Results: This study recruited 177 individuals: 78 (44.10%) males and 99 (55.90%) females. The mean age in the case group was 36.95±13.30 and in the control group, it was 21.34±12.60 years. The mean vitamin D levels had no significant difference between the case (19.68±13.60) and the control groups (21.34±12.60) (P>0.05).
Conclusion: The findings of this study showed that there was no significant difference in vitamin D levels between the case group and the control group, which did not support the hypothesis that vitamin D deficiency is associated with psoriasis.
Original Article
Physical Education
mitra khademosharie; azam mollanovruzi
Abstract
Introduction: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing two types of diabetes. Gestational diabetes can cause various complications for the mother and fetus. Therefore, this study aimed to investigate ...
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Introduction: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing two types of diabetes. Gestational diabetes can cause various complications for the mother and fetus. Therefore, this study aimed to investigate the effect of 12 weeks of combined training on the levels of some adipokines in women with gestational diabetes.
Materials and Methods: For this purpose, among pregnant women aged 25 to 35 years with gestational diabetes and gestational age of 13 to 14 weeks, 28 people were voluntarily selected to conduct the research and randomly divided into two groups, the experimental group (14 people) and the control (14 people). The combined exercise training program was as follows: for 12 weeks, three training sessions were held each week. Measurements and blood tests were performed 24 hours before the start of training and 24 hours after the last training session. To analyze the data, ANOVA test with repeated measures (repeated measure ANOVA) was used. The significance level was considered p≤0.05 and the data was analyzed using SPSS version 23 software.
Results: 12 weeks of combined exercise training caused a significant increase in the hormone adiponectin (P=0.001) and a significant decrease in the hormone visfatin (P=0.001) in the experimental group.
Conclusion: The results of the above research showed that women with gestational diabetes can benefit from many advantages, including the improvement of adiponectin and visfatin secreted from fat tissue, with correct and principled exercise training.
Original Article
Mohammad solimani farsani; mohammad fathi; zahra hemati; zinab gorgin
Abstract
Introduction: Exercise is a promising non-pharmacological option to potentially delay the onset or slow the progression of Alzheimer's disease. Therefore, this research seeks to find the possible mechanism of the connection between muscle and hippocampus under the influence of swimming exercise in rats ...
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Introduction: Exercise is a promising non-pharmacological option to potentially delay the onset or slow the progression of Alzheimer's disease. Therefore, this research seeks to find the possible mechanism of the connection between muscle and hippocampus under the influence of swimming exercise in rats with Alzheimer's disease. The significance level was 0.05.
Materials and Methods: Thirty-two 6-week-old rats were randomly divided into four groups: sham (SH), Alzheimer's control (AC), training (T) and Alzheimer's training (AT). Alzheimer's was induced by injecting beta-amyloid into the hippocampus. The training program consisted of 20 swimming training sessions with increasing time. After the end of the intervention, the tissue of the Gastrocnemius muscle and hippocampus was removed and the expression of the desired proteins was measured by immunohistofluorescent staining method. A correlation test was used to check the changes of the studied indicators.
Results: The results showed that the expression of neuron cell adhesion molecule, SEMA3A and profilins proteins had a significant positive relationship with NACHRa7 (P=0.001) and a significant inverse relationship with NLRP1 (P≥0.05) and Dead Cells (P≥0.05).
Conclusion: It seems that the induction of Alzheimer's causes the destruction of the neuromuscular junction and motor neurons. It can be effective in increasing hippocampus inflammation, on the other hand, swimming exercises is an effective intervention to improve axonal regeneration and neuron plasticity in motor neurons, and therefore it can be an effective intervention to prevent and control the complications of Alzheimer's disease in old age.