Document Type : Original Article
Authors
1 lorestan university
2 Lorestan university
3 ardakan University
4 farhangiyan university
Abstract
Introduction: Exercise is a non-drug option to prevent or slow the progression of Alzheimer's. Therefore, this research seeks to find the possible mechanism of the connection between muscle and hippocampus..
Materials and methods: 32 6-week-old rats were randomly divided into four groups: sham (SH), Alzheimer's control (AC), training (T) and Alzheimer's training (AT). Alzheimer's was induced by injecting beta-amyloid into the hippocampus. The training program consisted of 20 swimming training sessions with increasing time. After the end of the intervention, the tissue of the Gastrocnemius muscle and hippocampus was removed and the expression of the desired proteins was measured by immunohistofluorescent staining method. Correlation test was used to check the changes of the studied indicators.
Findings: The results showed that the expression of NCAM, SEMA3A and Pfn1 proteins had a significant positive relationship with NACHRa7 (P=0.001) and a significant inverse relationship with NLRP1 (P≥0.05) and Dead Cells (P≥0.05). they had.
Conclusion: Hippocampal inflammation and Alzheimer's progression can be prevented by physical activity and strengthening the neuromuscular junction.
Keywords
)