Original Article
Physiology & Pharmacology
Mina Abroudi; Ghazaleh Dadashizadeh; saeideh sadat shobeiri; Azar Hosseini; omid gholami; Reza Ataee Disfani; Davood Mahdian; MARYAM KHOSROJERDI
Abstract
Background: Cancer is considered as an important global health problem. Chemotherapy drugs used in cancer treatment have side effects such as bone marrow suppression, hair loss, gastrointestinal lesions, drug resistance, neurological dysfunction and heart toxicity. Flavonoids are bioactive compounds ...
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Background: Cancer is considered as an important global health problem. Chemotherapy drugs used in cancer treatment have side effects such as bone marrow suppression, hair loss, gastrointestinal lesions, drug resistance, neurological dysfunction and heart toxicity. Flavonoids are bioactive compounds found in most plants and have beneficial effects on various cancerous tissues. Hesperidin is found as a flavonoid in the citrus family. In this research, the anticancer effects of hesperidin on different cancer cell lines, including adrenal medullary tumor (pheochromocytoma) (PC12), colon adenocarcinoma (SW48), prostate cancer (DU145) and esophageal squamous cell carcinoma (KYSE30) were investigated.
Methods: Cells were treated with different concentrations of hesperidin (0.75-100 μM) for 24, 48 or 72 hours, and cell viability was evaluated by MTT method. In addition, the expression of Bax, Bcl-2 and caspase-3 genes was measured using RT-PCR. Also, cell apoptosis was evaluated by flow-cytometry.
Results: The results showed that hesperidin prevents the proliferation of different cancer cells. Also, flow-cytometry results showed that hesperidin can increase cell apoptosis, which was confirmed by gene expression results. Hesperidin significantly decreased the expression of bcl-2 gene while increasing the expression of Bax and Caspase-3 (p<0.05).
Conclusion: It seems that hesperidin as a natural product can be used in the treatment of all types of human cancers in combination with chemical drugs.
Original Article
Nursing
hamid movahedzadeh; majid ghodsi; manijeh yosefi mighaddam; moslem mansuri; mohammad sadeghian; alireza ghorbani
Abstract
Background: Cardiovascular disease is currently one of the world's most common and serious life-threatening diseases. Although the death rate caused by heart surgery is decreasing worldwide, there are still avoidable deaths in low-risk patients. This study investigates factors affecting mortality ...
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Background: Cardiovascular disease is currently one of the world's most common and serious life-threatening diseases. Although the death rate caused by heart surgery is decreasing worldwide, there are still avoidable deaths in low-risk patients. This study investigates factors affecting mortality in these patients after heart surgery.
Materials and methods: This study investigated all cases of open heart surgery between 2018 and 2021 in Heshmatieh Hospital of Sabzevar . The main variables of the research include the number of deaths and the cause of death in the patients up to 30 days after open heart surgery.
Results: Overall, 406 male and 204 female patients were studied in this research. The studied patients had an average age of 61.77 years with an average height of 166.32 ± 10.02 cm and an average weight of 78 ± 14.5 kg. In addition, 165 patients had high blood pressure, and 586 patients had coronary heart disease
Discussion and conclusion: Although underlying factors such as age and previous diseases affect mortality after surgery, preventing infection, fever, and discharge after surgery can reduce the mortality percentage.
Original Article
Psychology
Fatemeh Abolhassani; hanifeh nohekhan; masoumeh ahmadpour hoseinizadeh; fatemeh asirhom; mansoureh khalili; vaziri shahram
Abstract
Background : People with gender dissatisfaction face many social and psychological problems. The aim of the current research was to determine the effectiveness of integrative analytical psychotherapy on the reflective reaction and interpersonal problems of people with transgender. Method: Research was ...
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Background : People with gender dissatisfaction face many social and psychological problems. The aim of the current research was to determine the effectiveness of integrative analytical psychotherapy on the reflective reaction and interpersonal problems of people with transgender. Method: Research was practical and its design was semi-experimental, of the single-subject type with a baseline. Among the clients with gender dysphoria who referred to the forensic medicine of Tehran province in 1401, 4 were selected by available sampling method and underwent integrative analytical treatment for 8 months. Data were collected in the three stages of baseline, treatment and follow-up for 9 months using reflective reaction questionnaire and interpersonal problems. In order to analyze the data, visual analysis was used to calculate the recovery percentage. Results: The results showed that in the stages of treatment and follow-up, the overall score of reflective reaction increased and interpersonal problems decreased significantly (P<0.05). The confidence index of reflective reaction has increased and the uncertainty index has decreased significantly, and these changes were stable over time. Also, the size of the treatment effect is high in the dimensions of openness, aggression, support of others and dependence. In terms of stability of changes, it can be concluded that changes are stable in all dimensions. Conclusion: It can be said that integrative analytical psychotherapy can improve reflective reaction and reduce interpersonal problems in people suffering from gender boredom. Therefore, mental health professionals can use this treatment to improve the mental health of people with sexual boredom.
Original Article
Epidemiology and Statistics
Afsane Esmaeili Ranjbar; Hamid Ostadebrahimi; Gholamreza Bazmandegan; Mitra Abasifard; Mojtaba Sanji Rafsanjani; zahra kamyab
Abstract
Background and Objectives: Discharge against medical advice can lead to a negative impact on treatment outcomes and costs. The aim of this recent study was to evaluate the causes of discharge against medical advice from the emergency department in Ali-Ibn Abi-Talib hospital, Rafsanjan.
Materials and ...
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Background and Objectives: Discharge against medical advice can lead to a negative impact on treatment outcomes and costs. The aim of this recent study was to evaluate the causes of discharge against medical advice from the emergency department in Ali-Ibn Abi-Talib hospital, Rafsanjan.
Materials and Methods: In this descriptive-analytical study, all 400 patients who were discharged against medical advice (DAMA) from the emergency department of Ali-Ibn Abi-Talib Hospital in the first half of 2019 entered the study by convineint sampling. To collect information, the Questionnaire of the ministry of health was applied.
Results: Our findings indicated in total of 25931 patients who dichargeed the prevalence of discharge against medical advice from the emergency department was 11.5% with a 95% confidence interval of 11.1% to 11.9%. In our sample, 57.8% (231 people) were male and 42.5% (170 people) were in the age range of 20 to 39 years. Our results revealed the rasons of DAMA in 300 cases (75%) was related to the patient such as feeling recovery or desire for treatment in private centers.There was a significant difference between patients' economic status, discharge insurance and age and the frequency of DAMA.
Conclusion: Based on the results of the present study, the majority of DAMA were due to personal reasons. Increasing the knowledge of the patients regarding probable consequences and improving the quality of medical services can help decrease DAMA cases.
Review article
Physiology & Pharmacology
akbar hajizadeh moghaddam; fatemeh zeini hamzekolaei; Sedigheh khanjani Jelodar
Abstract
Background: Oxidative stress is recognized as a key factor in Alzheimer's disease, disrupting the balance of the antioxidant system. Studies have shown that some microalgae contain powerful antioxidant compounds that can help prevent nerve damage and the progression of Alzheimer's disease. ...
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Background: Oxidative stress is recognized as a key factor in Alzheimer's disease, disrupting the balance of the antioxidant system. Studies have shown that some microalgae contain powerful antioxidant compounds that can help prevent nerve damage and the progression of Alzheimer's disease. This study aims to explore the potential of extracts and biologically active compounds derived from microalgae for the management and treatment of Alzheimer's disease.
Methods: The therapeutic properties and characteristics of microalgae were researched by collecting data from databases such as PubMed, ISI, SID, ScienceDirect, and Google Scholar between 1998 and 2023. Among the articles reviewed, those related to the neuroprotective effects of microalgae in neurodegenerative diseases were analyzed in this study.
Results: Microalgae are rich in nutrients and can produce antioxidants under stressful conditions, helping to defend the body. Some green algae extracts have been reported to have inhibitory effects on cholinesterase activity and may improve cholinergic deficits in Alzheimer's patients.
Conclusion: Biochemical compounds found in microalgae are rich in neuroprotective potential, making them an excellent renewable source for producing pharmaceutical compounds and nutritional supplements for the prevention and treatment of Alzheimer's disease.
Original Article
Psychology
Vahid manzari; Mokhtar Weisani; Serveh Ghasemi
Abstract
چکیده
زمینه و هدف: افراد دارای اختلال وسواس فکری-عملی طیفی از انواع خطاهای شناختی مشکلات هذیانی را تجربه می-کنند که نیازمند شناخت بیشتر مداخلات درمانی است. پژوهش حاضر ...
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چکیده
زمینه و هدف: افراد دارای اختلال وسواس فکری-عملی طیفی از انواع خطاهای شناختی مشکلات هذیانی را تجربه می-کنند که نیازمند شناخت بیشتر مداخلات درمانی است. پژوهش حاضر با هدف بررسی اثربخشی آموزش مفاهیم طرحواره درمانی بر باورهای هذیانی و اجتناب شناختی در افراد دارای علائم وسواس فکری- عملی انجام شد.
مواد و روشها: پژوهش حاضر نیمه آزمایشی از نوع پیش آزمون- پس آزمون و پیگیری با گروه کنترل بود. جامعه آماری شامل افراد دارای اختلال وسواس فکری-عملی مراجعه کننده به مراکز مشاوره و روانپزشکی شهر سنندج در سال 1401-1402 بود که با استفاده از روش نمونه گیری در دسترس تعداد 30 نفر از آنها که شرایط ورود به پژوهش را داشتند انتخاب و سپس با توجیه اهداف پژوهش و داشتن رضایت برای حضور در پژوهش به شیوه تصادفی در دو گروه آزمایش و کنترل (هر گروه 15 نفر) قرار داده شدند. درمان مفاهیم طرحوارهدرمانی در 8 جلسه 90 دقیقهای و هفتهای یکبار برای گروه آزمایش اجرا شد و گروه کنترل هیچگونه مداخلهای را در این مدت دریافت نکردند. جهت جمع آوری دادهها از پرسشنامههای وسواس فکری عملی براون (1989)، هذیان پیترز (2013) و اجتناب شناختی سکستون و دوگاس (2004) استفاده شد. دادهها با استفاده از نرم افزار SPSS نسخه 24 و روش تحلیل واریانس تحلیل گردید.
یافتهها: نتایج تحلیل یافته ها نشان داد که: آموزش مفاهیم طرحواره درمانی باعث کاهش باورهای هذیانی و اجتناب شناختی شده است که این تأثیر در سطح 05/0 معنی دار بود. همچ
Original Article
dentistry
akram mehrandasht; mohammad mehdizadeh; ali morshedi; mohammad aghaali; mohammad arjmandnia
Abstract
The inherent tendency of blood to clot plays a central role in the formation of clots. Anticoagulant agents should considered as an essential tool in the management and treatment of patients with coagulation problems. The purpose of this study is to investigate the level of knowledge of dentists in the ...
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The inherent tendency of blood to clot plays a central role in the formation of clots. Anticoagulant agents should considered as an essential tool in the management and treatment of patients with coagulation problems. The purpose of this study is to investigate the level of knowledge of dentists in the fields of anticoagulant drugs and necessary measures for the treatment of bleeding in dental procedures.
Materials and Methods: This article is a cross-sectional analytical study that conducted in the Faculty of Dentistry on general dentists of Qom University of Medical Sciences in 1401. Chi-square and Fisher test used to analyze the collected data. Data analyzed with SPSS version 26 software
Results: Among 121 general dentists with an average age of 6.89 ± 30.56 years and 5.80 ± 4.46 years of work experience after graduation, 69 were male and 52 were female. A significant percentage of the responses to each question in the questionnaire related to their lack of knowledge about anticoagulant and antiplatelet drugs. There was no significant relationship between gender, age and work experience of dentists with most questions in the questionnaire. (p>0.81)
Conclusion: Because a percentage of general dentists do not know about well-known drugs, many medical errors can be reduced by holding annual continuous training and informing city-level dentists and codified training for students.
Original Article
nutrition
Maryam Ranjbar Zahedani; shaghayegh Rakhshbahar; Nazanin Tavakoli; Fatemeh Najm; Fatemeh Sarvi; atefeh Akrami; Razieh Zolghadr
Abstract
Background: As a determinant of health behaviors, emotional intelligence can influence anthropometric factors. Adolescence is a critical and transitional period of growth in a person's life. During this phase, individuals experience physical, psychological and emotional-social transformations. ...
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Background: As a determinant of health behaviors, emotional intelligence can influence anthropometric factors. Adolescence is a critical and transitional period of growth in a person's life. During this phase, individuals experience physical, psychological and emotional-social transformations. Emotional intelligence emerges as a crucial factor in addressing adolescent challenges.
This study aimed at investigating the relationship between anthropometric factors and emotional intelligence in students of Academic year 2022 of Lar city, Iran.
Materials and Methods: This is a descriptive-analytical, cross-sectional study in type and nature, and in terms of purpose, it is an applied study. The data was collected through International Physical activity Questionnaire (IPAQ), Shutte emotional intelligence questionnaire and demographic questionnaire. Independent t-test, Pearson's correlation and Linear regression analysis were employed for comparing quantitative variables, assessing the correlation between them and investigating the impact of variables on the response variable. The statistical population of the study included 177 adolescents aged 12-18 in the city of Lar, who were selected by cluster random sampling method. Spss v.23 was used for data analysis.
Results: Based on the multiple regression results, children's anthropometric indices had no significant relationship with emotional intelligence. The effect of Body Mass Index on emotional intelligence was not statistically significant at any level (p<0.05) and there was no statistically significant relationship between activity level and emotional intelligence (p=0.457).
Conclusions: According to the results, there was no robust and statistically significant correlation between anthropometric indicators and emotional intelligence.
Original Article
Psychology
Kimia Sahraian; leila Razeghian Jahromi; Danial Salehi; sedighe nasiripoor; shima dehghanzadeh; sanaz garmsirinezad
Abstract
Purpose: Drug use is one of the common problems in society, and many drug users have mental health problems that sometimes cause or exacerbate psychiatric disorder. One of the most important obstacles to seeking treatment services is internalized stigma, which directly affects the quality of life of ...
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Purpose: Drug use is one of the common problems in society, and many drug users have mental health problems that sometimes cause or exacerbate psychiatric disorder. One of the most important obstacles to seeking treatment services is internalized stigma, which directly affects the quality of life of the consumer and causes negative feelings and maladaptive behavior. This indicates the importance of psychological interventions to reduce the sense of stigma experienced. This study aimed to determine the effectiveness of acceptance and commitment-based therapy on quality of life and internal stigma in drug users.
Method: The statistical population of this research included all the people who visited Ostad Mohrhari Hospital in Shiraz during the months of January and February to get rid of addiction. In this research, 30 drug users were randomly divided into two experimental and control groups. Questionnaires of quality-of-life scale (Forman & Herbert, 2009 ) and perceived stigma (Leink & Falan, 2017) were used. The experimental group underwent a treatment program based on acceptance and threat, but the control group did not receive any intervention.
Findings: The average score of internal stigma and quality of life in the experimental group decreased compared to the control group (P<0.05). A significant difference was observed between the two experimental and control groups in the post-test scores (P<0.05).
Conclusion: The treatment program based on acceptance and commitment had a positive effect on increasing the quality of life and reducing internal stigma in drug-using patients.
Original Article
Nursing
Mohammad Abbasinia; Atye Babaii; Hakimeh Dehghani; ashraf khoramirad; Amirmohammad Bakhtiari; Atena Hakimzadeh; Bahman Aghaie
Abstract
Background: It seems that the competence to maintain patient safety is affected by the culture of patient safety. the aim was determining the status of patient safety culture and its relationship with the competence of maintaining patient safety in nurses working in hospitals of Qom University of Medical ...
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Background: It seems that the competence to maintain patient safety is affected by the culture of patient safety. the aim was determining the status of patient safety culture and its relationship with the competence of maintaining patient safety in nurses working in hospitals of Qom University of Medical Sciences.
Materials and Methods: In a cross-sectional study, 338 nurses working in the hospitals of Qom University of Medical Sciences by quota sampling method and random in each hospital were examined in 1402. The tools used were patient safety culture and patient safety competency questionnaires. The data was analyzed in SPSS-21 software using Pearson correlation and multivariate linear regression. A significance level of 0.05 was considered.
Results: The patient's safety culture was observed in the studied sample at an average level. The results of the multivariate linear regression test showed that the frequency of reporting events and communication and providing feedback about errors were most related to the patient's safety competence (P<0.05). So for each unit increase in the average frequency of reporting incidents, the patient's safety competence increases by 0.19, and for each unit increase in the average communication and feedback about errors, the patient's safety competence increases by 0.22.
Conclusion: The patient safety culture is at the average level, and due to the relationship between the patient safety culture and the competence to patient safety, interventions to improve the patient safety culture in hospitals are emphasized.
Original Article
Psychology
Shakila Yousefi; Mahdi Nayyeri; mohammad Reza Seirafi
Abstract
Introduction: Multiple sclerosis (MS) is a chronic and debilitating disease that has a profound impact on patients' physical, emotional, and social well-being. The primary objective of this study was to examine the impact of group training on behavioral activation centered on self-care within a ...
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Introduction: Multiple sclerosis (MS) is a chronic and debilitating disease that has a profound impact on patients' physical, emotional, and social well-being. The primary objective of this study was to examine the impact of group training on behavioral activation centered on self-care within a family-based framework for patients diagnosed with multiple sclerosis.
Materials and Methods: The present study was based on a quasi-experimental design consisting of pre-test and post-test evaluations. It involved 40 male and female MS patients aged 20-55 in Torbat E Jam, who were selected through convenience sampling and then randomly assigned to either the experimental or control groups. The experimental group received 8 sessions of family-oriented behavioral activation training, each lasting 90 minutes, over a period of 2 months. A The instrument of this study was the 12-item self-care scale developed by Jarsma was administered before and after the training, and the data were analyzed using repeated measures analysis of variance (ANOVA).
Results: The findings of the study indicated that family-oriented group behavioral activation training sessions significantly enhanced the self-care of individuals diagnosed with multiple sclerosis.
Conclusion: Behavioral activation, as a family-centered intervention, has demonstrated effectiveness in improving the self-care abilities of inpatients with multiple sclerosis. Healthcare providers should consider incorporating this intervention into the care plans of patients with multiple sclerosis and their families.
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