نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه باکتری شناسی و ویروس شناسی، دانشکده پزشکی، دانشگاه علوم پزشکی تبریز، تبریز، ایران

2 کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی ایران، تهران، ایران

چکیده

چکیده
هلیکوباکتر پیلوری اولین باکتری سرطان زایی است که به رسمیت شناخته شده و این باکتری یکی از پاتوژن های مهم انسانی است. اگر درمان ضروری صورت نگیرد، کلونیزاسیون معمولاً مادام العمر ادامه می یابد. هلیکوباکتر پیلوری عامل اصلی بیماری های مختلف دستگاه گوارش شامل گاستریت مزمن فعال، بدون علائم بالینی تا زخم گوارشی، آدنوکارسینوم معده و لنفوم بافت لنفاوی مرتبط با مخاط معده است. در این بررسی مروری به برخی از پیشرفت های اخیر در روش های تشخیصی عفونت هلیکوباکتر پیلوری در شرایط بالینی مختلف پرداخته شده است. در تشخیص بالینی هلیکوباکتر پیلوری باید از آزمایش هایی استفاده شود که از دقت بالایی برخوردار هستند، بطوریکه حساسیت و ویژگی بیش از 90٪ داشته باشد. در انتخاب آزمایش مربوطه باید همه موارد از جمله شرایط بالینی، نسبت احتمال آزمایش های مثبت و منفی، مقرون به صرفه بودن، استراتژی های مربوطه و در دسترس بودن آن ها در نظر گرفته شود.

کلیدواژه‌ها

عنوان مقاله [English]

Recent advances in the diagnosis of Helicobacter pylori infection

نویسندگان [English]

  • Reza Ghotaslou 1
  • Tahereh pirzadeh 1
  • Aylin Esmailkhani 1
  • Abed Zahedi Bialvaie 2
  • Hamed Ebrahimzadeh Leylabadlo 1

1 Department of Bacteriology and Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

2 Student Research Committee, Iran University of Medical Sciences, Tehran, Iran

چکیده [English]

Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most effective human pathogens, as over half of the world's population is colonized with this Gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of the various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma (MALT). This review concerns some of the most recent developments in diagnostic methods of H. pylori infection and it has been studied in different clinical conditions. Only highly accurate tests should be used in clinical practice, and the sensitivity and specificity of an adequate test should exceed 90%. The choice of tests should take all items among into account clinical circumstances, the likelihood ratio of positive and negative tests, the cost-effectiveness of the testing strategy, and the availability of the tests.

کلیدواژه‌ها [English]

  • Helicobacter pylori
  • Diagnosis
  • Endoscopy
  • Histology
  • Culture
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