. Ansa BE, Coughlin, Steven S,Alema-Mensah, Ernest Smith, Selina A,, AL E. Evaluation of colorectal cancer incidence trends in the United States (2000–2014). Journal of Clinical Medicine. 2018;7(2):22.
. Dolatkhah R, Somi, MH, Bonyadi, MJ, Asvadi Kermani, I, Farassati ,F, Dastgiri ,S. , al. e. Colorectal cancer in iran: molecular epidemiology and screening strategies. . J Cancer Epidemiol. 2015;2015:643020
. Rafa H, Benkhelifa,S, AitYounes,S, Saoula,H., al. e. All-Trans Retinoic Acid Modulates TLR4/NF-kB Signaling Pathway Targeting TNF-alfa and Nitric Oxide Synthase 2 Expression in Colonic Mucosa during Ulcerative Colitis and Colitis Associated Cancer. Mediators of Inflammation. 2017:1-16.
. M. Ramos ML, M. Esteva. , . ea. “Knowledge and attitudes of primary healthcare patients regarding population based screening for colorectal cancer,”. ,BMC Cancer,. 2011: 11:408,1-11.
. Hanash SM BC, Kallioniemi .,et al. Emerging molecular biomarkers–blood-based strategies to detect and monitor cancer. . Nat Rev Clin Oncol.,2011;8:142-150.
. Masatsune Shibutani KM, Hisashi Nagahara, Tatsunari Fukuoka, Shigetomi Nakao, Shinji Matsutani,Kosei Hirakawa and Masaichi Ohira.,et al. The peripheral monocyte count is associated with the density of tumorassociated macrophages in the tumor microenvironment of colorectal cancer: a retrospective study. BMC Cancer. 2017;17:404:1-7.
. Mairi H. McLean1 GIM, Keith N. Stewart,,et al. The Inflammatory Microenvironment in Colorectal Neoplasia. plos one. 2010;6:1-8.
. M. Honda YS, T. Yamashita. ,et al. “Differential gene expression profiling in blood from patients with digestive system cancers,”. Biochemical and Biophysical Research Communications,. 2010;400,no.1: 7–15.
. Ziegler H, Ancuta, P, Crowe ,S, Dalod ,M, Grau, V, Hart ,DN, ,et al. Nomenclature of monocytes and dendritic cells in blood. Blood. 2010;116(16):e74-80.
. Coillard A, Segura, Elodie. In vivo differentiation of human monocytes. Frontiers in immunology. 2019;10:1907.
. Carlin LM,et al. Nr4a1-dependent Ly6c low monocytes monitor endothelial cells and orchestrate disposal. Cell. 2013;153(2):362-75.
. Imhof BA,et al. CCN1/CYR61- mediated meticulous patrolling by LY6clow monocytes fuels vascular inflammation. Proc Nat Acad Sci,. 2016:201607710.
. Yang J, Zhang L, Yu C, Yang X-F, Wang H. Monocyte and macrophage differentiation: circulation inflammatory monocyte as biomarker for inflammatory diseases. Biomarker research. 2014;2(1):1-9.
. Stanilova. NSSDMGDPJMCA,etal.Monocytes expression of IL-12 related and IL-10 genes in association with development of colorectal cancer. molecular biology reports. 2012;39:10895-902.
. Hennessy E, Parker ,AE,’Neill ,LAJ. ,et al. Targeting Toll-like receptors:emerging therapeutics? Nat Rev Drug Discov. 2010;(9):293-307.
. Basith S MB, Yoo TH, Kim SG, Choi S .,et al. Roles of toll-like receptors in cancer: a double-edged sword for defense and offense. Arch Pharm Res. 2012;35:1297-316.
. Chow MT, Möller, Andreas,Smyth, Mark J, editor. Inflammation and immune surveillance in cancer.Elsevier Seminars in cancer biology; 2012;(22):23-32.
. Kolb RL, Janowski, AM, Sutterwala ,FS, et al,. Inflammasomes in cancer: a double-edged sword Protein,Cell. 2014;5 (1):12-20.
. Janakiram NB, Chinthalapally V. The role of inflammation in colon cancer. Inflammation and cancer. 2014:25-52.
. N.S. Stanilov ZGDSAS,et al. Higher TNF-Alpha Production Detected in Colorectal Cancer Patients Monocytes. Biotechnology & Biotechnological Equipment. 2012:107-10.
. Mehrzad J, Bahari,A., Bassami ,MR., et al., Immunobiologically relevant level of aflatoxin B1 alters transcription of key functional immune genes, phagocytosis and survival of human dendritic cells. /jimlet. 2018;197:44-52.
. Ali Ghorbani Ranjbary, Jalil Mehrzad, Hesam Dehghani AASH,et al. Variation in Blood and Colorectal Epithelia’s Key Trace Elements Along with Expression of Mismatch Repair Proteins from Localized and Metastatic Colorectal Cancer Patients. Biological Trace Element Research. 2019;194:66-75.
. Chang Y-T, Huang, Chi-Shuan,Yao, Chung-Tay,Su, Sui-Lung,Terng, Harn-Jing,Chou, Hsiu-Ling,et al. Gene expression profile of peripheral blood in colorectal cancer. World journal of gastroenterology: WJG. 2014;20(39):14463.
. Fridman W, Pag`es,F,Saut`es-Fridman,C, and Galon,J, al. e. “The immune contexture in human tumours: impact on clinical outcome,” Nature Reviews Cancer. 2012;12,no.4:298–306.
. Zhang F, Wang ,H, Wang ,X, et al, al. e. TGF-β induces M2-like macrophage polarization via SNAIL-mediated suppression of a proinflammatory phenotype. Oncotarget. 2016;(7):52294-306.
. Taryn L, Santos,MF, Ahmed, A,et al.Toll-like receptor (TLR) expression of immune system cells from 2 metastatic breast cancer patients with circulating tumor cells. Experimental and Molecular Pathology. 2014;97(1):44-8.
. Rebecca Kesselring JG, 2 Andreas Hiergeist,et al. IRAK-M Expression in Tumor Cells Supports Colorectal Cancer Progression through Reduction of Antimicrobial Defense and Stabilization of STAT3. Cancer Cell. 2016;29:684-96.
. Qin He1 YF, Dean Tian1, Wei Yan1,et al. The contrasting roles of inflammasomes in cancer. Am J Cancer. 2018;8(4):566-83.
. Ye .X Q, X, al. e. Gene Expression Analysis of Peripheral Blood Cells Reveals Toll-Like Receptor Pathway Deregulation in Colorectal Cancer. PLoS One. 2013;8(5):e62870.
. Sarra Benkhelifa HR, said Belhadef,Hayat Ait-kaci,oussama Medieber Morad,et al. Aberrant upregulation of iNOS/NO system is correlated with an increased abundance of Foxp3+ cells and reduced effector/memory cell markers expression during colorectal cancer: immunomodulatory effects of cetuximab combined with chemotherapy. Inflammopharmacology. 2019;27(4):685-700.