تیموزین آلفا-1 (زاداکسین): پپتید تیموسی با طیف وسیعی از فعالیت‏های بیولوژیکی و بالینی

نوع مقاله : مروری

نویسندگان

1 کارشناسی‏ارشد بیوشیمی،گروه شیمی، دانشکده علوم، دانشگاه فردوسی مشهد، مشهد، ایران

2 استاد، گروه شیمی، دانشکده علوم، دانشگاه فردوسی مشهد، مشهد، ایران

چکیده

زمینه و هدف  تیموزین آلفا-1 (زاداکسین)، پپتید 28 اسیدآمینه‏ای می‏باشد که اولین‌بار از تیموس گوساله شناسایی شد. این پپتید، یک اصلاح‌کننده واکنش زیستی می‎باشد که منجر به فعال شدن سلول‎های مختلف سیستم ایمنی می‎شود. در سال‏های اخیر، تیموزین آلفا-1 در مطالعات درون‏تنی و برون‏تنی به‌منظور بررسی فعالیت زیستی و کاربردهای درمانی آن مورد مطالعه قرار گرفته است.
مواد و روش‌ها در این پژوهش، تعدادی از مطالعات موجود در زمینه تیموزین آلفا-1 از طریق جستجوی الکترونیکی با وارد کردن کلید واژه‏های تیموزین آلفا-1، تنظیم سیستم ایمنی، سرطان، هپاتیت و ایدز در بانک‏های اطلاعاتی نظیر Google، Google Scholar و PubMed بین سال‎های 1966 تا 2019 نقد و بررسی شدند.
یافته‏ها نتایج نشان داد که تیموزین آلفا-1 با گیرنده‏های Toll-like receptors (TLR) برهم‏کنش برقرار می‏کند و منجر به فعال‎سازی برخی از مسیرهای داخل سلولی می‎شود که در نهایت سبب تحریک سیستم ایمنی از طریق تحریک تولید سیتوکین‎ها، افزایش سلول‎های T و دندریتیک می‏گردد. این پپتید همچنین دارای فعالیت ضدتوموری و نیز خاصیت دفاع در برابر آسیب‏های اکسیداتیو از طریق افزایش سطح آنزیم‎های آنتی‎اکسیدانی می‏باشد. تیموزین آلفا-1 کاربرد بالینی گسترده‎ای در برابر بسیاری از بیماری‎های عفونی از جمله هپاتیت B و C و ایدز نشان داده است. علاوه بر این، استفاده از تیموزین آلفا-1 می‏تواند در درمان برخی سرطان‏ها از جمله سرطان هپاتوسلولار و ملانوما بسیار امیدبخش باشد.
نتیجه‌گیری نتایج مطالعه حاضر نشان‌دهنده خواص بیولوژیکی چندگانه تیموزین آلفا-1 می‏باشد. با این وجود، مطالعات بیشتری به‌منظور درک سازوکار عمل تیموزین آلفا-1 مورد نیاز است.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Thymosin alpha-1 (Zadaxin): A thymic peptide with a wide range of biological and clinical activities

نویسندگان [English]

  • Jasmin Kharazmi-Khorassani 1
  • Ahmad Asoodeh 2
1 M.Sc in Biochemistry, Department of chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
2 PhD, Department of chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
چکیده [English]

Introduction: Thymosin alpha-1 (zadaxin) a 28-amino acid peptide, which was first identified in the calf thymus. This peptide is a biological modifier which leads to activation of various cells of the immune system. In the recent years, thymosin alpha-1 has been studied in in vitro and in vitro studies to evaluate its biological activities and therapeutic applications. 
Materials and Methods: This study was done to summarize findings from the biological and clinical applications of thymosin alpha-1 peptide. We searched at the sites of Google, Google Scholar and PubMed over 1966-2019 using Thymosin alpha-1, Immunomodulatory, Cancer, Hepatitis and AIDS as keywords. Results: The results showed that thymosin alpha-1 interacts with Tolllike receptors (TLR) and brings about to activation of some intracellular pathways that ultimately stimulate the immune system by modulating cytokine production, enhancing T-cell and dendritic cells. The peptide also shows antitumor activity and a protective role against oxidative damage by increasing the level of antioxidant enzymes. Clinical studies with thymosin alpha-1 have been shown a broad effective application against many infectious diseases, including hepatitis B and C and AIDS. In addition, thymosin alpha-1 is considered as a promising and adjunctive approach for subjects suffering from some cancers such as hepatocellular carcinoma and melanoma.
Conclusion: The results of this study indicate the multiple biological properties of thymosin alpha-1. However, further studies are needed to understand the mechanism of action of thymosin alpha-1. 

کلیدواژه‌ها [English]

  • Thymosin alpha-1
  • Immunomodulatory
  • cancer
  • Hepatitis
  • AIDS
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