نوع مقاله : مقاله پژوهشی
نویسندگان
- داریوش مسلمی 1
- یاور رجب زاده 2
- عمادالدین موعودی 3
- معصومه کریمی 4
- سهراب کاظمی 5
- علی اکبر مقدم نیا 5
- دانیال فضیلت پناه 6
- سکینه سلیمانی ورکی 2
- علیرضا تاجی 2
- سید حسن عابدی 7
- داود جهانسوز 2
1 استاد رادیواونکولوژی، دانشگاه علوم پزشکی بابل
2 مرکز تحقیقات سرطان، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل
3 گروه اورولوژی، دانشگاه علوم پزشکی بابل
4 گروه علوم آزمایشگاهی، دانشگاه علوم پزشکی بابل
5 مرکز تحقیقات زیست شناسی سلولی و مولکولی، پژوهشکده سلامت، دانشگاه علوم پزشکی بابل
6 مرکز تحقیقات سرطان، دانشگاه علوم پزشکی بابل، بابل، ایران
7 گروه داخلی، دانشکده پزشکی، دانشگاه علوم پزشکی بابل، بابل، ایران
چکیده
زمینه و هدف: سرطان پروستات یکی از شایعترین سرطانهای مردان است. استفاده از رادیوتراپی در درمان قطعی و یا ادجوانت در این بدخیمی نقش بسزایی در بهبود بقای بدون بیماری و بقای کلی بیماران دارد. با توجه به اثرات ضدالتهابی کوئرستین، به نظر میرسد که انمای آن بتواند احتمال ایجاد پروتکتیت در بیماران تحت رادیوتراپی لگنی را کاهش دهد. این مطالعه باهدف ارزیابی اثربخشی پماد کوئرستین در پیشگیری از پروکتیت حاد ناشی از پرتودرمانی در بیماران مبتلابه سرطان پروستات انجام شد.
مواد و روشها: در این کار آزمایی بالینی دو سوکور با گروه موازی، 50 بیمار مبتلابه سرطان پروستات کاندید رادیوتراپی بهصورت تصادفی در دو گروه کوئرستین (پماد کوئرستین دو درصد، همزمان با شروع رادیوتراپی هرروز، روزی دو بار 5 سیسی کوئرستین بهصورت تنقیه) و کنترل وارد شدند. بیماران ازنظر فراوانی پروکتیت، اسهال، خونریزی مقعد، درد مقعد و اورژانسی مدفوعی در کنار کیفیت زندگی پیگیری شدند. دادههای دو گروه در سطح معناداری 05/0>p مقایسه شد.
یافتهها: در مقایسه بین دو گروه در هفتههای مختلف، اختلاف معناداری ازنظر فراوانی پروکتیت و علائم همراه گزارش نشد. همچنین کیفیت زندگی بیماران بین دو گروه نیز اختلاف معناداری نداشت.
نتیجهگیری: نتایج این مطالعه نشان داد که استفاده از کوئرستین با کاهش عوارض گوارشی ناشی از رادیوتراپی همراهی ندارد.
تازه های تحقیق
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کلیدواژهها
موضوعات
عنوان مقاله [English]
Quercetin Enema in The prevention of Radiation-Induced Acute Proctitis in Prostate Cancer Patients: A Randomized Controlled Trial
نویسندگان [English]
- Dariush Moslemi 1
- Yavar Rajabzadeh 2
- Emadoddin Moudi 3
- Masoomeh Karimi 4
- Sohrab Kazemi 5
- Ali Akbar Moghadamnia 5
- Danial Fazilat-Panah 6
- Sakineh Soleimani Varaki 2
- Alireza Taji 2
- Seyed Hassan Abedi 7
- Davoud Jahansouz 2
1 Professor of Radiation Oncology Babol University of Medical Sciences, Babol, Iran
2 Cancer Research Center. Health Research Institute. Babol University of Medical Sciences, Babol, Iran
3 Department of Urology. Babol University of Medical Sciences, Babol, Iran
4 Department of Laboratory Sciences. Babol University of Medical Sciences, Babol, Iran
5 Cellular and Molecular Biology Research Center. Health Research Institute. Babol University of Medical Sciences, Babol, Iran
6 Cancer Research Center, Babol University of Medical Sciences, Babol, Iran
7 Department of Internal Medicine, School of Medicine. Babol University of Medical Sciences, Babol, Iran
چکیده [English]
Introduction: Prostate cancer is one of the most prevalent cancers in men. The use of radiotherapy, either as definitive or adjuvant treatment, significantly improves disease-free and overall survival rates. However, the inevitable effects of ionizing radiation on healthy tissues, such as the rectum, can compromise the efficacy of radiotherapy by delaying treatment and diminishing quality of life. Given the established anti-inflammatory properties of quercetin, we hypothesized that quercetin enemas would reduce the incidence of proctitis in patients undergoing pelvic radiotherapy. This study aimed to evaluate the effectiveness of quercetin in preventing acute proctitis caused by radiation therapy in prostate cancer patientss.
Materials and Methods: In this double-blind randomized controlled trial, 50 patients with prostate cancer scheduled for radiotherapy were randomly assigned to two parallel groups: the quercetin group (receiving a 5 cc quercetin 2% solution enema twice daily from the start of radiation therapy until 7 weeks post-treatment) and the placebo group. Patients were monitored for the frequency of proctitis, diarrhea, rectal bleeding, rectal pain, stool urgency, and quality of life.
Results: During the course of radiotherapy, the frequency of proctitis, diarrhea, rectal bleeding, and rectal pain increased significantly in both groups. However, no significant differences were observed regarding the incidence of proctitis and its associated symptoms between the two groups during treatment. Additionally, quality of life was comparable across both groups.
Conclusion: Quercetin enema did not demonstrate a reduction in radiation-induced acute proctitis in prostate cancer patients.
کلیدواژهها [English]
- Prostatic Neoplasms
- Radiotherapy
- Quercetin
- Proctitis
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