نوع مقاله : مروری
نویسندگان
1 دانشیار آموزش بهداشت و ارتقای سلامت، گروه آموزش بهداشت و ارتقای سلامت، دانشکده بهداشت، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.
2 دانشآموخته بهداشت محیط، گروه بهداشت محیط، دانشکده بهداشت، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.
3 کارشناس بهداشت عمومی، کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران
4 مرکز تحقیقات بیماری های غیرواگیر، گروه بهداشت مجیط، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران.
چکیده
زمینه و هدف: آلودگی هوا بهعنوان عامل سرطانزای گروه یک شناختهشده و با پیامدهای بهداشتی مختلف ازجمله سرطان مرتبط است. این مطالعه به بررسی نظاممند ارتباط بین مواجهه با آلودگی هوا و خطر ابتلا به سرطان معده پرداخته است.
مواد و روشها: مقالات از پایگاههای اطلاعاتی معتبر شامل PubMed, Scopus, Web of Science تا اکتبر 2024 با استفاده از کلیدواژههای ("Air pollution," "particulate matter," or "PM2.5," "PM10," or "dust," or "coarse particle") AND ("Gastric cancer," or "Gastric neoplasm") مطابق با اصطلاحات MESH استخراج شدند. معیارهای ورود شامل مطالعات کوهورت بررسیکننده مواجهه با آلودگی هوا مانند PM2.5، PM10 و ارتباط آن با خطر ابتلا به سرطان معده بود. از میان 1693 مقاله اولیه، 8 مطالعه متناسب با معیارهای ورود برای تحلیل نهایی انتخاب و تحلیل دادهها با استفاده از دستورالعملهای PRISMA انجام شد.
یافتهها: مطالعات مختلف نتایج متفاوتی را بیان داشتند. برخی مطالعات تأثیر جنسیت برافزایش خطر ابتلا به سرطان معده در مواجهه با ذرات معلق را گزارش دادند(HR = 1.98; 95% CI: 1.30, 3.01) این امر میتواند به دلیل ترکیبی از عوامل بیولوژیکی، مواجهات شغلی و تفاوتهای سبک زندگی، مانند نرخ بالاتر سیگار کشیدن در مردان باشد. برخی مطالعات نیز در ایالاتمتحده (HR = 1.00; 95% CI: 0.91, 1.09) و تایوان (HR = 0.97; 95% CI: 0.82, 1.15) ارتباط معنیداری گزارش نکردند
نتیجهگیری: این مطالعه مرور نظاممند نشان داد که مواجهه با آلودگی هوا، بهویژه ذرات معلق ریز (PM2.5)، میتواند خطر ابتلا به سرطان معده را افزایش دهد.
تازه های تحقیق
https://scholar.google.com/citations?user=uRV6dbQAAAAJ&hl=id
https://pubmed.ncbi.nlm.nih.gov/?term=HAMID+JOVEINI
https://scholar.google.com/scholar?hl=id&as_sdt=0,5&q=afshin+dowlatabadi&btnG=
https://pubmed.ncbi.nlm.nih.gov/?term=Dowlatabadi+A&cauthor_id=37705571
https://scholar.google.com/scholar?hl=id&as_sdt=0,5&q=Faezeh+Karimi+Moghaddam&btnG=
https://scholar.google.com/citations?hl=en&tzom=-210&user=Zx049B0AAAAJ&view_op=list_works
https://pubmed.ncbi.nlm.nih.gov/?term=MOHAMMAD+MIRI
کلیدواژهها
موضوعات
عنوان مقاله [English]
Association between Air Pollution Exposure (Particulate Matter) and Risk of Gastric Cancer: A Systematic Review
نویسندگان [English]
- Hamid Joveini 1
- Afshin Dowlatabadi 2
- Faeze karimi-moghadam 3
- Mohammad Miri 4
1 Associate Professor of Health Education and Health Promotion , Department of Health Education and Health Promotion, Faculty of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
2 Environmental health Graduates, Department of Environmental Health, School of Public Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
3 Public Health Graduates, Student Research Committee, Sabzevar Univertsity of Medical Sciences, Sabzevar, Iran
4 .Noncommunicable Diseases Research Center, Environmental Health Department, School of Public Health, Sabzevar University of Medical Sciences, Sabzevar, Iran
چکیده [English]
Introduction: Air pollution is a recognized contributor to various adverse health outcomes, including cancer. This study systematically reviews the association between air pollution exposure and the risk of gastric cancer.
Materials and Methods: A systematic review was conducted in accordance with PRISMA guidelines. Articles published up to October 2024 were retrieved from Web of Science, PubMed, Scopus, and other databases. The search strategy included keywords such as "air pollution," "particulate matter," "PM2.5," "PM10," "dust," and "coarse particles," combined with "gastric cancer" and "gastric neoplasm." Inclusion criteria focused on cohort studies examining the relationship between air pollution exposure (e.g., PM2.5, PM10) and gastric cancer risk. Exclusion criteria comprised animal studies and non-English publications.
Results: From an initial pool of 1,693 records, eight studies were included, covering diverse geographic regions, including Europe, Asia, and the United States. Associations between PM2.5 exposure and gastric cancer risk varied, with hazard ratios (HR) ranging from 0.97 (95% CI: 0.82–1.15) to 1.98 (95% CI: 1.30–3.01). A stronger positive association was observed in men, possibly due to greater occupational and lifestyle-related exposure. Overall, exposure to particulate matter was significantly associated with an increased risk of gastric cancer (HR = 1.38; 95% CI: 0.99–1.92), with men exhibiting a higher risk (HR = 1.98; 95% CI: 1.30–3.01). Regional differences in study outcomes underscored the heterogeneity of air pollution’s health impacts.
Conclusion: Emerging evidence from this systematic review identifies air pollution, and specifically PM2.5, as a modifiable environmental risk factor for gastric cancer.
کلیدواژهها [English]
- Air Pollution
- Environmental Exposure
- Gastric Cancer
- PM2.5
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