تاثیرهشت هفته تمرین هوازی تداومی و تناوبی بر سطح سرمی پروتئین واکنشی C و مولکول های چسبان در مردان مبتلا به نارسایی قلبی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری، گروه تربیت بدنی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران.

2 استادیار، گروه تربیت بدنی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران

3 دانشیار گروه تربیت بدنی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران

4 عضو هیات علمی گروه تربیت بدنی، واحد نیشابور، دانشگاه آزاد اسلامی، نیشابور، ایران

چکیده

مقدمه
شواهد نشان داده اند که مولکول های چسبان و میانجی های التهابی نقش مهمی در پاتوژنز آترواسکلروز دارند. هدف تاثیرهشت هفته تمرین هوازی تداومی و تناوبی بر سطح سرمی پروتئین واکنشی C و مولکول های چسبان در مردان مبتلا به نارسایی قلبی بود.
روش کار
در این پژوهش، 42 نفر مرد میانسال با نارسایی قلبی، هدفمند انتخاب و تصادفی به سه گروه مساوی(14 نفر) تمرین هوازی تداومی، هوازی تناوبی و کنترل تقسیم شدند. تمرین تداومی(شدت 45 تا 70 درصد ضربان قلب بیشینه) و تمرین تناوبی(شدت 45 تا 80 درصد ضربان قلب بیشینه با استراحت 5 تا 10 دقیقه ای بین هر تناوب) به مدت هشت هفته(سه روز در هفته) بود. قبل و پس از اجرای تمرین نمونه خونی از سه گروه گرفته، به روش الایزا اندازه گیری شد. برای تحلیل داده ها از نرم افزار SPSS نسخه 20 در سطح معنی داری 05/0≥P استفاده شد.
نتایج
پس از هشت هفته تمرین سطح سرمی پروتئین واکنشی C، مولکول چسبان سلولی-1 و مولکول چسبان عروقی-1 در دو گروه تمرینی کاهش معنی دار داشت(P ≤ 0.05)، ولی در گروه کنترل تفاوتی معنی دار دیده نشد. در سطوح hs-CRP (P = 0.023) و VCAM-1(P = 0.0001) در هر سه گروه تفاوت معنی داری دیده شد، اما تفاوت معنی داری در سطح ICAM-1(P = 0.17). در بین سه گروه مشاهده نشد.
نتیجه گیری
تمرین هوازی با کاهش سطوح hs-CRP و VCAM-1 احتمالا نقش موثری در پیشگیری و کنترل بیماری های قلبی-عروقی مردان نارسایی قلبی دارد.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

The effect of eight weeks of continuous and periodic aerobic exercise on serum C-reactive protein and adhesion molecules in men with heart failure

نویسندگان [English]

  • Ladan Hosseini Abrishami 1
  • Seyed Mahmud Hejazi 2
  • Amir Rashdlamir 3
  • Rambod Khajei 4
1 Ph.D. Student , Department of physical education, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran.
2 Assistant professor, Department of physical education, Neyshabour branch, Islamic Azad University, Neyshabour , Iran
3 Associate Professor, Department of physical education, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran.
4 Ph.D, Department of physical education, Neyshabour Branch, Islamic Azad University, Neyshabour, Iran.
چکیده [English]

Introduction
Evidence showed that adhesion molecules and inflammatory factors play an important role in the pathogenesis of atherosclerosis.The purpose of this study was to evaluate the effect of eight weeks of continuous and periodic aerobic exercise on the serum level of C-reactive protein and some adhesive molecules in men with heart failure.
Materials and Methods
In this study, 42 middle-aged men with heart failure were purposeful and randomly divided into three equal groups(14 subjects): continuous aerobic exercise, periodic aerobic exercise and control groups. Continuous training(45-70% of Maximum Heart Rate) and periodic exercise (45-80% of MHR with 5-10 minutes rest between each period) were done for 8 weeks(three days a week). Before and after exercise, blood samples were taken from three groups, ELISA method was used. Data were analyzed using SPSS (20 version) at a significant level of P≤0.05.
Results
After eight weeks of training, the level of C-reactive protein, adhesion molecule -1 and vascular adhesion molecule -1 had a significant decrease in the two training groups(P ≤ 0.05). but no significant difference was observed in the control group. There was a significant difference between the levels of hs-CRP(P = 0.023) and VCAM-1(P = 0.0001) in all three groups, but there was not a significant difference in ICAM-1 level(P = 0.17).
Conclusion
Aerobic exercise by decreasing the levels of hs-CRP and VCAM-1 may play an important role in the prevention and control of cardiovascular disease in men with heart failure.

کلیدواژه‌ها [English]

  • Keywords: "hs-CRP"
  • "ICAM-1"
  • "VCAM-1"
  • "Aerobic Training"
  • "Heart Failure"
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