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Abstract
Background and Purpose: Lamotrigine is a novel potential antiepileptic drug which is not structurally dependent on the current antiepileptic drugs; it has fewer side effects too. The present study intends to assess the effects of Lamotrigine on the antinociceptive activity induced by morphine by using the formalin test as a test of nociception. Methods and Materials: This experimental study was conducted on 56 adult male rats. The animals were divided into seven groups of eight rats considered as one control one sham and five experimental groups (one group receiving 2mg/Rat of morphine alone three groups receiving 2mg/Rat morphine accompanied by Lamotrigine in doses of 25 50 and 75 mg/Rat and the fifth group receiving only 75 mg/Rat of Lamotrigine alone). The drugs were intraperitoneally injected 15 minutes before the formalin test. The sham group received the same volume of physiologic serum and the control group received formalin alone. The study data were analyzed in SPSS using Tukey and Kruskal Wallis test; level of significance was considered to be 0.05. Results: Mean pain score following the injection of maximum dose of lamotrigine together with morphine was 0.08±0.001 which indicated more local analgesic effects at the acute phase in comparison with the injection of morphine alone (0.11±0.0005) (p
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