نوع مقاله : مقاله پژوهشی
نویسندگان
1 استاد یار رادیولوژی، دانشگاه علوم پزشکی شهید بهشتی، بیمارستان شهدای تجریش، تهران، ایران
2 مرکز توسعه تحقیقات بالینی، بیمارستان آموزشی شهید مدرس، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
3 مرکز تحقیقات پوست، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران
4 دانشکده پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران
5 گروه رادیولوژی، بیمارستان شریعتی، دانشگاه علوم پزشکی تهران، تهران، ایران
چکیده
زمینه و هدف: افیوژن پلورال یکی از تظاهرات بالینی شایع است که میتواند نشانهای از بیماریهای سیستمیک یا موضعی مانند بدخیمی، عفونت، یا نارسایی قلبی باشد. تمایز بین افیوژنهای ترانسوداتیو و اگزوداتیو برای تشخیص و درمان مناسب اهمیت بالایی دارد. هدف این مطالعه، بررسی ویژگیهای آزمایشگاهی مایع پلور و ارتباط آن با نوع افیوژن بود.
مواد و روشها: این مطالعه توصیفی-مقطعی روی ۹۷ بیمار بستری با افیوژن پلورال در بیمارستان شهدای تجریش طی سالهای ۱۳۹۸ تا ۱۴۰۲ انجام شد. اطلاعات بیماران از طریق چکلیست مرور پروندههای پزشکی و آزمایشگاهی جمعآوری شد.
یافتهها: نسبت پروتئین مایع به سرم (R²=0.87, p<0.05) و نتایج کشت با نوع مایع رابطه معناداری نشان دادند. مایعات اگزوداتیو بیشتر کشت مثبت داشتند. همچنین بین افزایش WBC و بروز سرطان در مایع پلور همبستگی مثبت معناداری یافت شد (R²=0.62, p<0.05).
نتیجهگیری: بررسیهای بیوشیمیایی مانند نسبت پروتئین، LDH و کشت میتوانند به تشخیص نوع افیوژن کمک کنند. دادهها نقش کلیدی آنالیز ترکیبی بالینی و آزمایشگاهی در تشخیص دقیق افیوژن پلور را نشان دادند و بر ضرورت مطالعات آیندهنگر برای اعتبارسنجی مارکرها تأکید دارند.
تازه های تحقیق
https://scholar.google.com/citations?hl=en&user=vsI-YMsAAAAJ
https://pubmed.ncbi.nlm.nih.gov/?term=Khameneh+A&filter=lang.english&filter=hum_ani.humans&size=20
https://scholar.google.com/citations?user=GOewL5gAAAAJ&hl=en
https://pubmed.ncbi.nlm.nih.gov/?term=Rama+Bozorgmehr&sort=date
https://scholar.google.com/citations?user=VcQXDaYAAAAJ&hl=en
https://scholar.google.com/citations?user=2sdcIqsAAAAJ&hl=en&oi=ao
https://pubmed.ncbi.nlm.nih.gov/?term=Ghorani+H&filter=lang.english&filter=hum_ani.humans&size=20
کلیدواژهها
موضوعات
عنوان مقاله [English]
Evaluation of Pleural Fluid Tapping Characteristics in Patients Referred to the Interventional Unit of Shahid Rajaee Hospital, Tajrish, from 2019 to 2023
نویسندگان [English]
- Arash Khameneh Bagheri 1
- rama bozogmehr 2
- Negin Ghafarzadeh 3
- matin noroozi 4
- Hamed Ghorani 5
1 Assistance professor of Radiology , Shahid Beheshti University of Medical Science,Shohadaye Tajrish Hospital,Tehran,Iran
2 Student ,School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Skin research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 School of Medicine, Isfahan University of Medical Science, Isfahan , Iran
5 Department of Radiology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده [English]
Introduction: Pleural effusion is a common clinical manifestation that may indicate serious systemic or localized diseases, including malignancy, infection, or heart failure. Accurate distinction between transudative and exudative effusions is crucial for effective diagnosis and treatment.
Materials and Methods: This descriptive cross-sectional study was conducted on 97 hospitalized patients with confirmed pleural effusion at Shohadaye Tajrish Hospital between 2019 and 2023. Data collection involved a review of medical records and laboratory reports, facilitated by a standardized checklist.
Results: A significant correlation was found between the pleural-to-serum protein ratio and the exudative nature of pleural fluid (R²=0.87, p<0.05). Additionally, positive microbial cultures were significantly more prevalent in exudative effusions. No significant difference was found in polymorphonuclear (PMN) cell counts between culture-positive and culture-negative samples. A positive association was noted between malignancy and elevated white blood cell (WBC) levels in pleural fluid (R²=0.62, p<0.05).
Conclusion: Biochemical parameters such as protein ratio, lactate dehydrogenase (LDH) levels, and culture results significantly contribute to the classification of pleural fluid. This study underscores the importance of an integrated diagnostic approach that combines laboratory markers, imaging, and clinical data. Further prospective, multicenter studies are recommended to validate these findings and support the routine implementation of such diagnostic strategies.
کلیدواژهها [English]
- Pleural effusion
- Transudate
- Exudate
- Pleural fluid
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