نوع مقاله : مقاله پژوهشی
نویسندگان
1 استادیار، گروه زیستشناسی، دانشگاه پیام نور، تهران، ایران
2 دانشیار، گروه زیستشناسی، دانشگاه پیام نور، تهران، ایران
3 کارشناس ارشد، گروه زیستشناسی، دانشگاه پیام نور، تهران، ایران
چکیده
زمینه و هدف: استفاده تشخیصی و درمانی از یدرادیواکتیو و اشعه ایکس موجب توجه به مخاطرات زیستی این عوامل شده است. هدف مطالعه حاضر، بررسی تغییرات هورمون ملاتونین متعاقب دریافت یدرادیواکتیو و اشعه ایکس بود.
مواد و روشها: 60 سر موش صحرایی نر بهطور تصادفی به سه گروه مساوی تقسیم شدند: گروه اول به عنوان گروه کنترل، گروه دوم به مدت 2 هفته 1 میلیکوری ید 131 دریافت کردند و گروه سوم تحت یک بار تابش اشعه ایکس قرار گرفتند. پس از بیهوشی، از قلب موشها خونگیری شد و سطح سرمی ملاتونین اندازهگیری گشت.
یافتهها: آنالیز دادهها کاهش معنادار سطح ملاتونین در گروه دوم را نسبت به گروه کنترل نشان داد ولیکن در گروه دریافتکننده اشعه ایکس تغییر چشمگیری در میزان این هورمون در مقایسه با گروه کنترل مشاهده نشد.
نتیجهگیری: میتوان چنین نتیجهگیری کرد که ید رادیواکتیو منجر به کاهش معنیداری در میزان هورمون ملاتونین میگردد.
تازه های تحقیق
https://scholar.google.com/citations?hl=en&user=Mm39w2IAAAAJ
https://pubmed.ncbi.nlm.nih.gov/?sort=jour&term=Dadfar+F
https://scholar.google.com/citations?hl=en&user=430kCpsAAAAJ
https://pubmed.ncbi.nlm.nih.gov/?term=Hamzeh+Ahmadian%5bAuthor%5d
https://scholar.google.com/citations?hl=en&user=W9JySvIAAAAJ
https://pubmed.ncbi.++nlm.nih.gov/?term=zahra+mortazavi&sort=jour
کلیدواژهها
موضوعات
عنوان مقاله [English]
The Effects of Ionizing Radiation and Radioactive Iodine on the Hormonal Changes of Melatonin in Adult Male Rats
نویسندگان [English]
- Fereshteh Dadfar 1
- Kourosh Bamdad 2
- Zahra Mortazavi 3
1 Assistant professor, Department of Biology, Payame Noor University, Tehran, Iran
2 Department of Biology, Faculty of sceinces, payame noor university, Tehran,Iran
3 Associate professor, Department of Biology, Payame Noor University, Tehran, Iran
چکیده [English]
Introduction: The diagnostic and therapeutic applications of radioiodine and X-rays have raised attention to the biological hazards of these agents. This study aimed to investigate the changes in melatonin hormone levels following exposure to radioiodine and X-ray radiation.
Materials and Methods: Sixty male rats were randomly divided into three equal groups: a control group, a group receiving 1 mCi of iodine-131 for 2 weeks, and a group exposed to X-ray radiation once. After anesthetization, blood samples were collected from the hearts of the rats, and serum melatonin levels were measured.
Results: Data analysis revealed a significant decrease in melatonin levels in the group treated with iodine-131 compared to the control group. However, no significant change in melatonin levels was observed in the X-ray exposure group compared to the control group.
Conclusion: The findings indicate that exposure to radioiodine leads to a significant reduction in the melatonin hormone levels, whereas X-ray exposure does not significantly affect melatonin levels.
کلیدواژهها [English]
- Pinal gland
- Melatonin
- Iodine 131
- X-ray
- Rat
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