نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد، گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران

2 استادیار، گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران

3 دانشیار، گروه فیزیولوژی ورزش، دانشکده علوم ورزشی، دانشگاه حکیم سبزواری، سبزوار، ایران

4 استادیار، گروه متابولیسم و غدد بزرگسالان، دانشگاه علوم پزشکی سبزوار، سبزوار، ایران

10.30468/jsums.2024.7738.3041

چکیده

زمینه و هدف: دیابت می‌تواند عامل تهدیدکننده­ای برای زندگی باشد و حفظ سطح قند خون، تغذیه مناسب و فعالیت­بدنی منظم برای کنترل دیابت و پیشگیری از عوارض آن، بسیار حیاتی است. هدف از تحقیق حاضر، بررسی تأثیر دوازده هفته تمرین باند مقاومتی بر سطوح اسپکسین و نشانگرهای مقاومت به انسولین زنان مبتلا به دیابت نوع دو بود.
مواد و روش­ها: در این مطالعه نیمه‌تجربی،22 زن مبتلا به بیماری دیابت نوع دو به‌صورت تصادفی در دو گروه باند مقاومتی (11 نفر) و کنترل (11 نفر) تقسیم شدند. برنامه تمرینی شامل 12 هفته، هرهفته سه جلسه و هرجلسه به مدت45 تا60 دقیقه انجام شد. از روش آنالیز واریانس یک‌طرفه با اندازه­های تکراری برای تغییرات درون و بین گروهی استفاده شد.
یافته­ها: نتایج نشان داد تغییرات تعاملی در سطوح اسپکسین سرمی در دو گروه تجربی و کنترل معنادار بود (0/012=p). در صورتی که تغییر معنی­داری در گلوکز (0/229=p)، انسولین (0/116=p) و شاخص مقاومت به انسولین دیده نشد (0/178=p). تغییرات درون‌گروهی در شاخص مقاومت به انسولین معنی­دار است (0/04=p). براساس نتایج آزمون تعقیبی بونفرونی، سطح اسپکسین سرمی بین پیش‌آزمون با هفته هشتم (0/141=p) و بین پیش‌آزمون و هفته دوازدهم (0/429=p) تفاوت معنی‌داری وجود ندارد.
نتیجه‌گیری: تمرینات باند مقاومتی نسبت به گروه کنترل باعث افزایش معنی­دار اسپکسین و بهبود قابل‌توجهی در غلظت گلوکز ناشتا، انسولین، شاخص مقاومت به انسولین می­شود. بنابراین احتمالاً اجرای تمرینات باند مقاومتی به عنوان جایگزین مناسبی برای تمرینات مقاومتی در خانه در میان افراد مبتلا به دیابت نوع دو پیشنهاد می­شود.

تازه های تحقیق

https://scholar.google.com/citations?hl=en&user=zBs31h4AAAAJ&view_op=list_works&citft=1&email_for_op=keyvanhejazi@gmail.com&gmla=AILGF5UuMr27qbpAo46PiVG_jiF4yeUiIykCZhYA1uQoYjC2wqOiutAuBJ5IEntaGbUbrZGbvTkBGh1QF4skgiPBcQ4h6XGDzlZsxC5lOwIV4aSaxIgo93HY3uN_DNlp5k6kXrhd0riUrzYtrus_kPQcU1IQ5vJAJfIZiv4u5L6oh82WE8rkyvPGzzV_tnrDAZzeysaosj7XQd6d3bvJJ8JmRA-Z6YQHEFG3llWXpoWlCO73NQ

https://pubmed.ncbi.nlm.nih.gov/?term=%20Azizeh+%20Toghdori

https://scholar.google.com/citations?user=pjbn35AAAAAJ&hl=en

https://pubmed.ncbi.nlm.nih.gov/?term=Keyvan+Hejazi

https://scholar.google.com/citations?user=Qw2bsFcAAAAJ&hl=en

https://pubmed.ncbi.nlm.nih.gov/?term=Roya+Askari

https://scholar.google.com/citations?hl=en&user=i6Mkf9UAAAAJ&view_op=list_works&sortby=pubdate

https://pubmed.ncbi.nlm.nih.gov/?term=Najmeh+Rahimi

 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of Twelve Weeks of Resistance Band Training on Levels of Spexin and Markers of Insulin Resistance in Women with Type 2 Diabetes

نویسندگان [English]

  • Azizeh Toghdori 1
  • Keyvan Hejazi 2
  • roya askari 3
  • , Najmeh Rahimi 4

1 MSc, Department of Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran

2 Assistant professor, Department of Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran

3 Associate professor, Department of Sport Physiology, Faculty of Sport Sciences, Hakim Sabzevari University, Sabzevar, Iran

4 Assistant professor, Department of Internal Medicine, Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran

چکیده [English]

Introduction: Diabetes can be a life-threatening condition, and maintaining blood sugar levels, proper nutrition, and regular physical activity are crucial for controlling diabetes and preventing its complications. The present study aimed to investigate the effect of twelve weeks of resistance band training on the levels of spexin and insulin resistance indices in women with type 2 diabetes.
Materials and Methods: In this semi-experimental study, 22 women with type 2 diabetes were randomly divided into two groups: resistance band (n=11) and control (n=11). The exercise program consisted of 12 weeks, three sessions per week, and each session lasted for 45 to 60 minutes. One-way ANOVA with repeated measures was used for within- and between-group changes.
Results: The results showed that the interaction changes in serum spexin levels were significant between the experimental and control groups (p=0.012). However, no significant changes were observed in glucose (p=0.229), insulin (p=0.116), and insulin resistance index (p=0.178). Within-group changes in the insulin resistance index were significant (p=0.04). According to the Bonferroni post-hoc test, there was no significant difference in serum spexin level between pre-test and the eighth week (p=0.141) and between pre-test and the twelfth week (p=0.429).
Conclusion: Resistance band training, compared to the control group, significantly increased spexin and led to a considerable improvement in fasting glucose concentration, insulin, and insulin resistance index. Therefore, it is suggested that resistance band training can be implemented as a suitable alternative to home-based resistance training for individuals with type 2 diabetes.

کلیدواژه‌ها [English]

  • Resistance exercise
  • Spexin
  • Insulin resistance
  • Type 2 diabetes
  1. Lin C-H, Ho C-W, Chen L-C, Chang C-C, Wang Y-W, Chiou C-P, et al. Effects of a 12-week exercise training on insulin sensitivity, quality of life, and depression status in patients with type 2 diabetes. Journal of Medical Sciences. 2017;37(6):227. DOI: 10.4103/jmedsci.jmedsci_68_17
  2. Wong MK, Sze KH, Chen T, Cho CK, Law HC, Chu IK, et al. Goldfish spexin: solution structure and novel function as a satiety factor in feeding control. American Journal of Physiology-Endocrinology and Metabolism. 2013;305(3):E348-E66. DOI: 10.1152/ajpendo.00141.2013
  3. Khadir A, Kavalakatt S, Madhu D, Devarajan S, Abubaker J, Al-Mulla F, et al. Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes. Sci Rep. 2020;10(1):10635. DOI: 10.1038/s41598-020-67624-z
  4. Zhang L, Li G, She Y, Zhang Z. Low levels of spexin and adiponectin may predict insulin resistance in patients with non-alcoholic fatty liver. Practical Laboratory Medicine. 2021;24:e00207. DOI: 10.1016/j.plabm.2021.e00207
  5. Fang P, Min W, Sun Y, Guo L, Shi M, Bo P, et al. The potential antidepressant and antidiabetic effects of galanin system. Pharmacology Biochemistry and Behavior. 2014;120:82-7. DOI: 10.1016/j.pbb.2014.02.018
  6. Legakis I, Mantzouridis T, Mountokalakis T. Positive correlation of galanin with glucose in type 2 diabetes. Diabetes Care. 2005;28(3):759-60. DOI: 10.2337/diacare.28.3.759
  7. Gu L, Ding X, Wang Y, Gu M, Zhang J, Yan S, et al. Spexin alleviates insulin resistance and inhibits hepatic gluconeogenesis via the FoxO1/PGC-1α pathway in high-fat-diet-induced rats and insulin resistant cells. Int J Biol Sci. 2019;15(13):2815. DOI: 10.7150/ijbs.3178
  8. Gu L, Ma Y, Gu M, Zhang Y, Yan S, Li N, et al. Spexin peptide is expressed in human endocrine and epithelial tissues and reduced after glucose load in type 2 diabetes. Peptides. 2015;71:232-9. DOI: 10.1016/j.peptides.2015.07.018
  9. Sassek M, Kolodziejski PA, Strowski MZ, Nogowski L, Nowak KW, Mackowiak P. Spexin modulates functions of rat endocrine pancreatic cells. Pancreas. 2018;47(7):904-9. DOI: 10.1097/MPA.0000000000001083
  10. Sassek M, Kolodziejski PA, Szczepankiewicz D, Pruszynska-Oszmalek E. Spexin in the physiology of pancreatic islets—mutual interactions with insulin. Endocrine. 2019;63:513-9. DOI: 10.1007/s12020-018-1766-2
  11. Sun X, Yu Z, Xu Y, Pu S, Gao X. The role of spexin in energy metabolism. Peptides. 2023:170991. DOI: 10.1016/j.peptides.2023.170991
  12. Tanday N, Lafferty RA, Flatt PR, Irwin N. Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists. Diabetes, Obesity and Metabolism. 2022;24(12):2353-63. DOI: 10.1111/dom.14821
  13. Bruce C, Kriketos A, Cooney G, Hawley J. Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes. Diabetologia. 2004;47:23-30. DOI: 10.1007/s00125-003-1265-7
  14. O’Leary VB, Marchetti CM, Krishnan RK, Stetzer BP, Gonzalez F, Kirwan JP. Exercise-induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J Appl Physiol. 2006;100(5):1584-9. DOI: 10.1152/japplphysiol.01336.2005
  15. Jeon CY, Lokken RP, Hu FB, Van Dam RM. Physical activity of moderate intensity and risk of type 2 diabetes: a systematic review. Diabetes Care. 2007;30(3):744-52. DOI: 10.2337/dc06-1842
  16. Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, et al. The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Arch Phys Med Rehabil. 2005;86(8):1527-33. DOI: 10.1016/j.apmr.2005.01.007
  17. Vinu W, Kuamr V. Remedial exercise training program (aerobic and brisk walk training) for type II diabetes (T2DM). SPORT TK-Revista EuroAmericana de Ciencias del Deporte. 2024;13:6-. DOI: https://DOI.org/10.6018/sportk.548491
  18. Sigal RJ, Kenny GP, Boulé NG, Wells GA, Prud'homme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med. 2007;147(6):357-69. DOI: 10.7326/0003-4819-147-6-200709180-00005
  19. Son WM, Park JJ. Resistance Band Exercise Training Prevents the Progression of Metabolic Syndrome in Obese Postmenopausal Women. J Sports Sci Med. 2021;20(2):291-9. DOI: 10.52082/jssm.2021.291
  20. Ooi TC, Mat Ludin AF, Loke SC, Fiatarone Singh MA, Wong TW, Vytialingam N, et al. A 16-week home-based progressive resistance tube training among older adults with type-2 diabetes mellitus: effect on glycemic control. Gerontology and Geriatric Medicine. 2021;7:23337214211038789. DOI: 10.1177/23337214211038789
  21. Geirsdottir O, Arnarson A, Briem K, Ramel A, Jonsson P, Thorsdottir I. Effect of 12-week resistance exercise program on body composition, muscle strength, physical function, and glucose metabolism in healthy, insulin-resistant, and diabetic elderly Icelanders. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2012;67(11):1259-65. DOI: 10.1093/gerona/gls096
  22. Kwak C-J, Kim YL, Lee SM. Effects of elastic-band resistance exercise on balance, mobility and gait function, flexibility and fall efficacy in elderly people. Journal of physical therapy science. 2016;28(11):3189-96. DOI: 10.1589/jpts.28.3189
  23. Smith MF, Ellmore M, Middleton G, Murgatroyd PM, Gee TI. Effects of resistance band exercise on vascular activity and fitness in older adults. Int J Sports Med. 2017;38(03):184-92. DOI: 10.1055/s-0042-121261
  24. Colado JC, Triplett NT. Effects of a short-term resistance program using elastic bands versus weight machines for sedentary middle-aged women. The Journal of Strength & Conditioning Research. 2008;22(5):1441-8. DOI: 10.1519/JSC.0b013e31817ae67a
  25. Gomez-Tomas C, Chulvi-Medrano I, Carrasco JJ, Alakhdar Y. Effect of a 1-year elastic band resistance exercise program on cardiovascular risk profile in postmenopausal women. Menopause. 2018;25(9):1004-10. DOI: 10.1097/GME.0000000000001113
  26. Tomeleri CM, Souza MF, Burini RC, Cavaglieri CR, Ribeiro AS, Antunes M, et al. Resistance training reduces metabolic syndrome and inflammatory markers in older women: a randomized controlled trial. J Diabetes. 2018;10(4):328-37. DOI: 10.1111/1753-0407.12614
  27. Chiang SL, Heitkemper MM, Hung YJ, Tzeng WC, Lee MS, Lin CH. Effects of a 12-week moderate-intensity exercise training on blood glucose response in patients with type 2 diabetes: A prospective longitudinal study. Medicine (Baltimore). 2019;98(36):e16860. DOI: 10.1097/MD.0000000000016860
  28. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. The Journal of Clinical Endocrinology & Metabolism. 2000;85(7):2402-10. DOI: 10.1210/jcem.85.7.6661
  29. Shamizadeh M, Zolfaghari MR, Fattahi A. Effect of eight weeks of aerobic and resistance training on adropin, spexin, and TNFα levels, as well as insulin resistance indices, in obese men with type 2 diabetes. Journal of Ilam University of Medical Sciences. 2023;31(5):70-84. http://sjimu.medilam.ac.ir/article-1-7995-en.html
  30. Karimi M, Baghaei-Barzabadi M. Effect of Exercise at Morning in Comparison with Evening on Response of Spexin and Leptin to Eight Weeks of Endurance Training in Obese Women. Journal of Animal Biology. 2023;16(1):247-55.
  31. Ceylan Hİ, Saygın Ö, Özel Türkçü Ü. Assessment of acute aerobic exercise in the morning versus evening on asprosin, spexin, lipocalin-2, and insulin level in overweight/obese versus normal weight adult men. Chronobiol Int. 2020;37(8):1252-68. DOI: 10.1080/07420528.2020.1792482
  32. Bagherslimi M, Fathi R, Khosravi A, Bahraini A, Shirazi A. The Effect of Single session of Aerobic Interval Exercise on Serum Spexin Levels in Active Young Men. Journal of Sport and Exercise Physiology. 2017;10(2):37-46.
  33. Kurowska P, Dawid M, Oprocha J, Respekta N, Serra L, Estienne A, et al. Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation. Biol Reprod. 2023;109(5):705-19. DOI: 10.1093/biolre/ioad108
  34. Walewski JL, Ge F, Lobdell IV H, Levin N, Schwartz GJ, Vasselli JR, et al. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet‐induced obesity. Obesity. 2014;22(7):1643-52. DOI: 10.1002/oby.20725
  35. Türkel İ, Memi G, Yazgan B. Impact of spexin on metabolic diseases and inflammation: An updated minireview. Exp Biol Med. 2022;247(7):567-73. DOI: 10.1177/15353702211072443
  36. Samadpour Masouleh S, Bagheri R, Ashtary-Larky D, Cheraghloo N, Wong A, Yousefi Bilesvar O, et al. The effects of TRX suspension training combined with taurine supplementation on body composition, glycemic and lipid markers in women with type 2 diabetes. Nutrients. 2021;13(11):3958. DOI: 10.3390/nu13113958
  37. Gouveia SSV, de Morais Gouveia GP, Souza LM, da Costa BC, Iles B, Pinho VA, et al. The effect of pilates on metabolic control and oxidative stress of diabetics type 2–A randomized controlled clinical trial. J Bodyw Mov Ther. 2021;27:60-6. DOI: 10.1016/j.jbmt.2021.01.004
  38. Hawamdeh Z, Baniata A, Mansi K, Nasr H, Aburjai T. Thyroid hormones levels in Jordanian athletes participating in aerobic and anaerobic activities. Scientific research and essays. 2012;7(19):1840-5. DOI: 10.5897/SRE11.1734
  39. Ashraf A, Palakkott A, Ayoub MA. Anti-insulin receptor antibodies in the pathology and therapy of diabetes mellitus. Curr Diabetes Rev. 2021;17(2):198-206. DOI: 10.2174/1573399816666200604122345
  40. Rivers SL, Klip A, Giacca A. NOD1: an interface between innate immunity and insulin resistance. Endocrinology. 2019;160(5):1021-30. DOI: 10.1210/en.2018-01061
  41. Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nature reviews Molecular cell biology. 2006;7(2):85-96. DOI: 10.1038/nrm1837
  42. Zhao X, An X, Yang C, Sun W, Ji H, Lian F. The crucial role and mechanism of insulin resistance in metabolic disease. Front Endocrinol (Lausanne). 2023;14:1149239. DOI: 10.3389/fendo.2023.1149239.
  43. Hassan RH, de Sousa ACP, Mahfouz R, Hainault I, Blachnio-Zabielska A, Bourron O, et al. Sustained action of ceramide on the insulin signaling pathway in muscle cells: implication of the double-stranded RNA-activated protein kinase. J Biol Chem. 2016;291(6):3019-29. DOI: 10.1074/jbc.M115.686949
  44. DiMenna FJ, Arad AD. The acute vs. chronic effect of exercise on insulin sensitivity: nothing lasts forever. Cardiovascular endocrinology & metabolism. 2021;10(3):149-61. DOI: 10.1097/XCE.0000000000000239
  45. Jiahao L, Jiajin L, Yifan L. Effects of resistance training on insulin sensitivity in the elderly: A meta-analysis of randomized controlled trials. Journal of exercise science and fitness. 2021;19(4):241-51. DOI: 10.1016/j.jesf.2021.08.002