نوع مقاله : مقاله پژوهشی

نویسندگان

استادیار گروه تربیت بدنی، دانشکده علوم انسانی، دانشگاه کوثر بجنورد، ایران

10.30468/jsums.2024.7725.3030

چکیده

زمینه و هدف: دیابت بارداری (GDM) یکی از شایع­ترین عوارض بارداری و شیوع آن در سراسر جهان همراه با افزایش دیابت نوع دو در حال افزایش است. دیابت بارداری می­تواند عوارض مختلفی را برای مادر و جنین به همراه داشته باشد. از این‌رو هدف از مطالعه حاضر، بررسی تأثیر ۱۲ هفته تمرین ترکیبی بر مقادیر برخی آدیپوکین­ها در زنان مبتلا به دیابت بارداری بود.
مواد و روش­ها: به این منظور، از بین زنان باردار 25 تا 35 سال مبتلا به دیابت بارداری و سن بارداری 13 تا 14 هفته، 28 نفر به‌طور داوطلبانه برای انجام پژوهش انتخاب و به‌طور تصادفی به دو گروه، گروه تجربی ( 14 نفر) و کنترل (14 نفر) تقسیم شدند. برنامه تمرین ترکیبی (هوازی و مقاومتی) در 12 هفته، هر هفته سه جلسه تمرینی بود. 24 ساعت قبل از شروع تمرینات و 24 ساعت پس از انجام آخرین جلسه تمرین، اندازه­گیری­های لازم و آزمایش‌های خونی، به عمل آمد. به‌منظور تجزیه‌وتحلیل داده­ها از آزمون آنووا با اندازه­گیری­های مکرر (repeated Measure ANOVA) استفاده شد. در تحقیق حاضر سطح معناداری 0/05> pدرنظر گرفته شد و داده‌ها با استفاده از نرم‌افزار SPSS نسخه 23 تجزیه و تحلیل گردید.
یافته­ها: 12 هفته تمرینات ترکیبی، سبب افزایش معنادار هورمون آدیپونکتین (0/001= P) و کاهش معنادار هورمون ویسفاتین (0/001 = P) در گروه تجربی شد.
نتیجه‌گیری: نتایج تحقیق فوق نشان داد که زنان باردار دیابتی می­توانند با تمرین درست و اصولی، از مزایای بسیاری، ازجمله بهبود ادیپونکتین و ویسفاتین ترشح‌شده از بافت چربی بهره­مند شوند.

تازه های تحقیق

https://scholar.google.com/citations?user=OBux_QIAAAAJ&hl=en

https://www.ncbi.nlm.nih.gov/myncbi/mitra.khadem.1/cv/1005875/

https://scholar.google.com/citations?view_op=list_works&hl=fa&user=sgq22KYAAAAJ

https://www.ncbi.nlm.nih.gov/myncbi/a.novruzi@yahoo.com/cv/

 

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The Effect of 12 Weeks of Combined Training on the Levels of Adiponectin and Visfatin in Women with Gestational Diabetes

نویسندگان [English]

  • mitra khademosharie
  • azam mollanovruzi

Assistant Professor, Department of Sport Sciences, Faculty of Humanities, Kosar University of Bojnord, Bojnord, Iran

چکیده [English]

Introduction: Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and its prevalence worldwide is increasing along with enhancing two types of diabetes. Gestational diabetes can cause various complications for the mother and fetus. Therefore, this study aimed to investigate the effect of 12 weeks of combined training on the levels of some adipokines in women with gestational diabetes.
Materials and Methods: For this purpose, among pregnant women aged 25 to 35 years with gestational diabetes and gestational age of 13 to 14 weeks, 28 people were voluntarily selected to conduct the research and randomly divided into two groups, the experimental group (14 people) and the control (14 people). The combined exercise training program was as follows: for 12 weeks, three training sessions were held each week. Measurements and blood tests were performed 24 hours before the start of training and 24 hours after the last training session. To analyze the data, ANOVA test with repeated measures (repeated measure ANOVA) was used. The significance level was considered p≤0.05 and the data was analyzed using SPSS version 23 software.
Results: 12 weeks of combined exercise training caused a significant increase in the hormone adiponectin (P=0.001) and a significant decrease in the hormone visfatin (P=0.001) in the experimental group.
Conclusion: The results of the above research showed that women with gestational diabetes can benefit from many advantages, including the improvement of adiponectin and visfatin secreted from fat tissue, with correct and principled exercise training.

کلیدواژه‌ها [English]

  • training
  • adiponectin
  • visfatin
  • gestational diabetes
  1. McCance DR, Cassidy L. Diabetes in pregnancy. Textbook of Diabetes. 2024:1034-71.
  2. McIntyre HD, Catalano P, Zhang C, Desoye G, Mathiesen ER, Damm P. Gestational diabetes mellitus. Nature reviews Disease primers. 2019 Jul 11;5(1):47. DOI: 10.1038/s41572-019-0098-8
  3. Moore TR, Smith C, Khardori R, Talavera F, Warshak C, Zurawin R. Diabetes mellitus and pregnancy. Apr; 2020.
  4. Farsi S, Azarbayjani MA, Hoseini SA, Peeri M. The effects of endurance training with Genistein on ICAM-1, VCAM-1, and CRP of diabetic rats. Iranian Journal of Diabetes and Obesity. 2016 Sep 10;8(3):121-8.(persian)
  5. Mallardo M, Ferraro S, Daniele A, Nigro E. GDM-complicated pregnancies: focus on adipokines. Molecular Biology Reports. 2021 Dec;48(12):8171-80. DOI: 10.1007/s11033-021-06785-0
  6. Pheiffer C, Dias S, Jack B, Malaza N, Adam S. Adiponectin as a potential biomarker for pregnancy disorders. International Journal of Molecular Sciences. 2021;22(3):1326. DOI: 10.3390/ijms22031326
  7. Baratto I, Daher S, Lobo TF, Araujo Junior E, Guazzelli CAF. Adiponectin and leptin serum levels in normal adolescent pregnancies. The Journal of Maternal-Fetal & Neonatal Medicine. 2021;34(12):2019-24. DOI: 10.1080/14767058.2019.1651836
  8. Moyce Gruber BL, Dolinsky VW. The Role of Adiponectin during Pregnancy and Gestational Diabetes. Life. 2023;13(2):301. DOI: 10.3390/life13020301
  9. Rahman M, Einstein G, Tulp O. Autonomic, immunological and endocrine influences on adipose tissue as an organ. Adv Obes Weight Manag Control. 2021;11(2):48-58.
  10. Saeidi A, Haghighi MM, Kolahdouzi S, Daraei A, Abderrahmane AB, Essop MF, et al. The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review. Obesity reviews. 2021;22(1):e13090. DOI: 10.1111/obr.13090
  11. Jiang YK, Deng HY, Qiao ZY, Gong FX. Visfatin level and gestational diabetes mellitus: a systematic review and meta-analysis. Archives of Physiology and Biochemistry. 2021;127(5):468-78. DOI: 10.1080/13813455.2021.1874997
  12. Fathey H, Wahid EA, Ahmad M, Fouad NTA. Visceral Adipose Tissue-Derived Serine Protease Inhibitor (VASPIN) as A Prognostic Marker in Systemic Hypertension. The Egyptian Journal of Hospital Medicine. 2022;86(1):877-81.
  13. Bayles MP. ACSM's exercise testing and prescription: Lippincott Williams & Wilkins; 2023.
  14. Mannucci E, Bonifazi A, Monami M. Comparison between different types of exercise training in patients with type 2 diabetes mellitus: A systematic review and network metanalysis of randomized controlled trials. Nutrition, Metabolism and Cardiovascular Diseases. 2021;31(7):1985-92. DOI: 10.1016/j.numecd.2021.02.030
  15. Verma J, Verma P. Determining sample size and power in research studies: Springer; 2020.
  16. Bhograj A, Suryanarayana K, Nayak A, Murthy N, Dharmalingam M, Kalra P. Serum adiponectin levels in gestational diabetes mellitus. Indian Journal of Endocrinology and Metabolism. 2016;20(6):752. DOI: 10.4103/2230-8210.192909
  17. Yetgin MK, Agopyan A, Küçükler FK, Gedikbaşı A, Yetgin S, Kayapınar FÇ, et al. The Effects of Resistance and Aerobic Exercises on Adiponectin, Insulin Resistance, Lipid Profile and Body Composition in Adolescent Boys with Obesity. Istanbul Medical Journal. 2020;21(3).
  18. Perales M, Santos-Lozano A, Ruiz JR, Lucia A, Barakat R. Benefits of aerobic or resistance training during pregnancy on maternal health and perinatal outcomes: A systematic review. Early human development. 2016;94:43-8. DOI: 10.1016/j.earlhumdev.2016.01.004
  19. Huifen Z, Yaping X, Meijing Z, Huibin H, Chunhong L, Fengfeng H, et al. Effects of moderate-intensity resistance exercise on blood glucose and pregnancy outcome in patients with gestational diabetes mellitus: A randomized controlled trial. Journal of Diabetes and its Complications. 2022;36(5):108186. DOI: 10.1016/j.jdiacomp.2022.108186
  20. Hosseini A, Kazemi N, Nouri R, Kurdi M, Kasraian M. The effect of aqua and resistance exercises on lipid profile, adiponectin, insulin and blood glucose of gestational diabetes patients. Iranian Journal of Women, Obstetrics and Infertility. 2018;21(4):8-18.(persian)
  21. Qingju W, Juan D, Fenglian L. Changes of serum adiponectin and glycated albumin levels in gestational diabetes mellitus patients and their relationship with insulin resistance. Iranian Journal of Public Health. 2020;49(7):1252. DOI: 10.18502/ijph.v49i7.3578
  22. . Gao S, Su S, Zhang E, Zhang Y, Liu J, Xie S, et al. The effect of circulating adiponectin levels on incident gestational diabetes mellitus: systematic review and meta‑ Annals of Medicine. 2023;55(1):2224046. DOI: 10.1080/07853890.2023.2224046
  23. Elbalshy MM, Mohamed ME, Rahma AF. Effect of aerobic exercise on serum adiponectin and serum malondialdehyde (MDA) in type 1 diabetic patients. Eur J Prev Med. 2017;5(5):71-6.
  24. Naghizadeh H, Heydari F, Pouzesh Jadidi G. The effect of 12 weeks of high-intensity interval training and curcumin consumption on glycemic index, adiponectin and lipid profile in obese men with type2 diabetes hyperlipidemia. Journal of Applied Health Studies in Sport Physiology. 2023;10(1):50-66.(persian)
  25. Howlader M, Sultana MI, Akter F, Hossain MM. Adiponectin gene polymorphisms associated with diabetes mellitus: A descriptive review. Heliyon. 2021;7(8). DOI: 10.1016/j.heliyon.2021.e07851
  26. Homayouni A, Bagheri N, Mohammad-Alizadeh-Charandabi S, Kashani N, Mobaraki-Asl N, Mirghafurvand M, et al. Prevention of gestational diabetes mellitus (GDM) and probiotics: mechanism of action: a review. Current diabetes reviews. 2020;16(6):538-45. DOI: 10.2174/1573399815666190712193828
  27. Kao HH, Hsu H-S, Wu TH, Chiang HF, Huang HY, Wang HJ, et al. Effects of a single bout of short-duration high-intensity and long-duration low-intensity exercise on insulin resistance and adiponectin/leptin ratio. Obesity research & clinical practice. 2021;15(1):58-63. DOI: 10.1016/j.orcp.2020.09.007
  28. Abedi B, Azarbayjani Ma, Peeri M, Rasaee Mj. The effect of a single session of resistance training on serum adiponectin level and insulin resistance index in sedentary men. Journal of Arak University of Medical Sciences. 2011;14(5):53-620.
  29. Trivett C, Lees ZJ, Freeman DJ. Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia. European Journal of Clinical Nutrition. 2021;75(12):1745-56. DOI: 10.1038/s41430-021-00948-9
  30. Hosseini A, Rezvanipour F, Kazemi N, Salehi O, Kasraeian M. The effect of six weeks aqua training in second trimester of pregnancy on visfatin and glucose tolerance of gestational diabetic women. Iranian Journal Of Diabetes And Metabolism. 2017;.17(1): 23-30.(persian)
  31. Rezaei Nasab H, RanjbarR, Habibi A, Afshoon poor M. The effect of eight weeks of combined training (aerobic - circuit resistance) on visfatin concentration, il-6 and tnf-α in obese men with type ii diabetes. Iranian Journal of Diabetes and Metabolism.2017;17 (1): 39-48.(persian)
  32. Jorge MLMP, de Oliveira VN, Resende NM, Paraiso LF, Calixto A, Diniz ALD, et al. The effects of aerobic, resistance, and combined exercise on metabolic control, inflammatory markers, adipocytokines, and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism. 2011;60(9):1244-52.  DOI: 10.1016/j.metabol.2011.01.006
  33. Seo D-i, So W-Y, Ha S, Yoo E-J, Kim D, Singh H, et al. Effects of 12 weeks of combined exercise training on visfatin and metabolic syndrome factors in obese middle-aged women. Journal of sports science & medicine. 2011;10(1):222.
  34. Hejazi K, Attarzadeh Hosseini SR, Fathie M, Mosaferi Ziaaldini M, Zaeemi M. The response of irisin serum levels to eight weeks aerobic training with moderate intensity in obese male Wistar rats. Daneshvar Medicine. 2020;25(6):49-56.(persian)
  35. Mazaki-Tovi S, Romero R, Kusanovic JP, Vaisbuch E, Erez O, Than NG, et al. Maternal visfatin concentration in normal pregnancy. Journal of perinatal medicine. 2009;37(3):206-17.
  36. Pavlová T, Novák J, Bienertová-Vašků J. The role of visfatin (PBEF/Nampt) in pregnancy complications. Journal of reproductive immunology. 2015;112:102-10.
  37. Górska M, Krętowski A, Nikołajuk A, Zonenberg A, Telejko B, Kuźmicki M, et al. Serum visfatin concentration is elevated in pregnant women irrespectively of the presence of gestational diabetes. Ginekologia Polska. 2009;80(1).
  38. Jurdana M, Petelin A, Bizjak MČ, Bizjak M, Biolo G, Jenko-Pražnikar Z. Increased serum visfatin levels in obesity and its association with anthropometric/biochemical parameters, physical inactivity and nutrition. e-SPEN Journal. 2013;8(2):e59-e67.
  39. Hosseinian M, Banitalebi E, Amirhosseini S. Effect of 12 weeks of intensive interval and combined training on apolipoprotein A and B, Visfatin and Insulin resistance in overweight middle-aged women with type 2 diabetes. Internal Medicine Today. 2016;22(3):237-45.(persian)
  40. Berndt J, Kloting N, Kralisch S, Kovacs P, Fasshauer M, Schon MR, et al. Plasma visfatin concentrations and fat depot–specific mRNA expression in humans. Diabetes. 2005;54(10):2911-6. DOI: 10.2337/diabetes.54.10.2911
  41. Hamza APDWR, Faisal AH, Khaleel AN, Naeaam MT, Jabar AS. Description of Visfatin Adipokine and its Roles on Inflammation and Coronary Heart Disease: A Review Study. Medical Science Journal for Advance Research. 2021;2(1):10-4.
  42. Ratajczak M, Krzywicka M, Szulińska M, Musiałowska D, Kusy K, Karolkiewicz J. Effects of 12-Week Combined Strength and Endurance Circuit Training Program on Insulin Sensitivity and Retinol-Binding Protein 4 in Women with Insulin-Resistance and Overweight or Mild Obesity: A Randomized Controlled Trial. Diabetes, Metabolic Syndrome and Obesity. 2024:93-106. DOI: 10.2147/DMSO.S432954
  43. Agueda M, Lasa A, Simon E, Ares R, Larrarte E, Labayen I. Association of circulating visfatin concentrations with insulin resistance and low-grade inflammation after dietary energy restriction in Spanish obese non-diabetic women: role of body composition changes. Nutrition, Metabolism and Cardiovascular Diseases. 2012;22(3):208-14. DOI: 10.1016/j.numecd.2010.06.010
  44. Xu F, Ning X, Zhao T, Lu Q, Chen H. Visfatin is negatively associated with coronary artery lesions in subjects with impaired fasting glucose. Open Medicine. 2022;17(1):1405-11. DOI: 10.1515/med-2022-0540.