اثر 8 هفته تمرین هوازی منظم بر سطوح TNF-α و نیم‌رخ لیپیدی دختران چاق

حبیبیان, معصومه; امیرنیاشوبی, سعید; ذاکری خطیر, امام علی

نوع مقاله : مقاله پژوهشی

نویسندگان

¹ دانشیار، گروه تربیت بدنی، واحد قائم‌شهر، دانشگاه آزاد اسلامی واحد قائم‌شهر، قائم‌شهر، ایران

² کارشناس ارشد، گروه تربیت بدنی، واحد قائم‌شهر، دانشگاه آزاد اسلامی واحد قائم‌شهر، قائم‌شهر، ایران

چکیده

زمینه و هدف چاقی دوران کودکی با افزایش خطر عوارض بیماری‌های قلبی- عروقی و متابولیکی از جمله هایپرلیپیدیما همراه است و به‌عنوان یک وضعیت التهابی مزمن با درجه کم در نظر گرفته می‌شود؛ از این رو هدف از مطالعه حاضر، بررسی اثر 8 هفته تمرین هوازی منظم بر سطوح فاکتور نکروزدهنده تومور آلفا (TNF-α) و نیم‌رخ لیپیدی دختران چاق بود.
مواد و روش‌ها در این مطالعه نیمه‌تحربی، 14 دختر چاق با میانگین سنی 1/18± 9/9 سال و شاخص توده بدن 95 درصد یا بیشتر، انتخاب و به‌طور تصادفی به گروه‌های تمرین و کنترل تقسیم شدند. تمرین هوازی شامل حرکات ورزشی با شدت 50 تا 70 درصد ضربان قلب حداکثر، 3 جلسه در هفته و به مدت 8 هفته بود. نمونه‌های خونی ناشتا قبل و 48 ساعت پس از آخرین مداخله جمع‌آوری شد. سطوح سرمی TNF-α، تری‌گلیسیرید، کلسترول تام، لیپوپروتئین با چگالی بالا (HDL-C) و لیپوپروتئین با چگالی کم (LDL-C) اندازه‌گیری شد. از آزمون‌های t مستقل و زوجی برای تجزیه و تحلیل داده‌ها استفاده شد (0/05>p).
یافته‌ها 8 هفته تمرین هوازی منجر به کاهش سطوح TNF-α، تری‌گلیسرید، کلسترول تام، LDL-C و افزایش سطوح HDL-C در دختران چاق شد (0/05>p). در مقایسه با گروه کنترل درصد تعییرات متغیرها در گروه تمرین بالاتر بود (0/05>p).
نتیجه‌گیری فعالیت ورزشی هوازی به‌عنوان یک مداخله درمانی غیردارویی برای کودکان چاق می‌تواند منجر به کاهش عوامل خطرزای بیماری‌های قلبی- عروقی و متابولیکی از طریق بهبود نیم‌رخ لیپیدی و کاهش التهاب سیستماتیک شود.

کلیدواژه‌ها

موضوعات

فیزیولوژی و فارماکولوژی

عنوان مقاله [English]

The Effects of 8 weeks of regular aerobic exercise on the TNF-α levels and lipid profile in obese girls

نویسندگان [English]

Masoumeh habibian ¹
Saied Amirnia Shobi ²
Emamali Zakeri Khatir ²

¹ Associate Professor in Exercise Physiology,Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran

² Master of Exercise Physiology, Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran

چکیده [English]

Introduction: Childhood obesity is associated with an increased risk for several metabolic and cardiovascular complications, and is now considered as a state of chronic low-grade inflammation. The aim of this study was to invistigate of the effect 8 weeks of regular aerobic exercise on the Tumor necrosis factor alpha (TNF-α) and lipid profile in obese girls.
Materials and Methods: This semi experimental research, 14 obese girls (mean age 9.9±1.18 year) whose body mass index was 95% or greater were selected and assigned randomly to two equal groups as follow: exercise and control groups. Aerobic exercise was consisted of exercise movements at 50% to 70% maximal heart rate and 3 sessions/week for 8 weeks. Fasting blood samples were collected before and 48 hour after the last intervention. The serum levels of TNF-α, triglycerides, total cholesterol, lowdensity lipoprotein cholesterol (LDLC) and high density lipoprotein cholesterol (HDL-C) were measured. Data were analyzed by paired and independent t tests. The level of statistical significance was set at p < 0.05.
Results: Eight weeks of aerobic exercise caused a significant decrease in TNF-α, triglycerides, total cholesterol, LDL-C and an increase in HDL-C levels (p < 0.05). Compared with the control group, the percent changes of these variabls in exercise training group were significantly greater (p < 0.05). Conclusion: Aerobic exercise as a non-medical therapeutic intervention for obese children can leads to reduced cardiovascular and metabolic diseases risk factors by improving lipid profiles and a reducse in systemic inflammation.
Received

کلیدواژه‌ها [English]

Aerobic exercise
Cholesterol
Triglycerides
Tumor necrosis factor-alpha
Obesity

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مجله دانشگاه علوم پزشکی سبزوار

اثر 8 هفته تمرین هوازی منظم بر سطوح TNF-α و نیم‌رخ لیپیدی دختران چاق

مراجع

مراجع

دوره 28، شماره 1
فروردین و اردیبهشت 1400
صفحه 134-142

اثر 8 هفته تمرین هوازی منظم بر سطوح TNF-α و نیم‌رخ لیپیدی دختران چاق

مراجع

مراجع

دوره 28، شماره 1فروردین و اردیبهشت 1400صفحه 134-142

دوره 28، شماره 1
فروردین و اردیبهشت 1400
صفحه 134-142