Authors
Abstract
Background: Transient global cerebral ischemia, which leads to the extensive neuronal damage in the brain, results in a deficit in learning and memory. We designed the present study to investigate the effect of exercise preconditioning on learning and spatial memory following transient cerebral ischemia in rat. Materials and methods: In this experimental study, 50 male wistar rats weighing 250-300g were randomly allocated into different groups. Exercise was done by treadmill and for inducing cerebral ischemia both common carotid arteries were occluded for 10 minutes. Memory was evaluated by use of a step-through passive avoidance task. Sensory motor deficites was assesed by adhesive removal test and for evaluating slip ratio we used ledge beam walking test. Reslults: One week after transient cerebral ischemia, response latency decreased in passive avoidance test. Also touch time, remove time and slip ratio were increased in these animals. Exercise preconditioning improved the measured indices in ischemic rats. Conclusion: Exercise preconditioning improved deficites in learning and memory and also sensory motor function following transient cerebral ischemia.
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