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he Effect of High Intensity Interval Training on Serum Levels of Liver Enzymes and Body Composition in Patients with Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Document Type : Review article

Authors

1 MSc in Exercise Physiology, Department of Physical Education and Sports Sciences, University of Yasouj, Yasouj, Iran.

2 MSc in Exercise Physiology, Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran.

3 Assistant Professor, Department of Sports Physical, Faculty of Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

4 Professor, Department of Physical Education and Sports Sciences,University of Birjand, Birjand, Iran.

5 Associate Professor, Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Shiraz University, Shiraz, Iran.

Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a clinical and pathological syndrome associated with increased serum levels of liver enzymes. High-intensity interval training (HIIT) has the potential to effectively reduce liver fat. The aim of this study was to evaluate the effect of intense intermittent exercise on serum levels of liver enzymes and body composition in patients with NAFLD.
Materials and Methods: A systematic search of English and Persian articles published in PubMed, Web of Science, Scopus, SID, and Magiran databases was conducted until January 2024. Mean differences and 95% confidence intervals (CIs) were calculated using a random effects model. Heterogeneity was evaluated using the I² test, and publication bias was assessed through visual analysis of the funnel plot and Egger's test.
Results: The results showed that intense interval training caused a significant decrease in ALT [SMD = -1.91 (-1.47 to -0.94), P = 0.001], AST [SMD = -0.79 (-1.07 to -0.52), P = 0.001], and ALP [SMD = -1.37 (-1.96 to -0.78), P = 0.001]. Additionally, body fat percentage [SMD = -0.57 (-0.94 to -0.21), P = 0.002], BMI [SMD = -0.67 (-0.93 to -0.42), P = 0.001], and waist-to-hip ratio (WHR) [SMD = -0.77 (-1.13 to -0.40), P = 0.001] were significantly improved in patients with NAFLD compared to the control group.
Conclusion: The results indicate that high-intensity interval training has beneficial effects on ALT, AST, ALP, and body composition, making it a viable option for patients with non-alcoholic fatty liver disease. It is recommended that patients with NAFLD incorporate this type of exercise to improve liver enzyme levels.

Keywords

Main Subjects

References
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Journal of Sabzevar University of Medical Sciences
Volume 31, Issue 6
January and February 2025
Pages 889-903
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History
  • Receive Date: 15 April 2024
  • Revise Date: 27 July 2024
  • Accept Date: 27 July 2024
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