Document Type : Original Article
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Abstract
Introduction: Parkinson's disease results from degenerative loss of dopaminergic neurons in the substantia nigra and other part of the brain stem. Oxidative stress plays a major role in neuronal death in this disease. The aim of this study is to evaluate the effect of Biarum carduchrum extract in treatment of Parkinson's disease.
Methods: Rats were divided randomly into 5 groups of 8 animals. The control group did not receive any lesion. In Parkinson's group, Parkinson was induced by injection of 6- OHDA in the right anterior mid-brain (MFB). Third, fourth and fifth groups received Biarum carduchrum extract at doses of 100, 200 and 400 mg/kg via gavage for 14 days, 7 days after induction of Parkinson models. On day 15 behavioral tests, including catalepsy and open field was performed.
Results: Parkinsonian group showed higher immobility time than control group in catalepsy test and rats treatment with Biarum carduchrum extract at doses of 200 and 400 dramatically reduce the immobilization time.
Discussion: The results of this study show that Biarum carduchrum extract can improve motor impairment induced by Parkinson's, although didn’t significantly affect knowledge and anxiety in rats.
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