Physiology & Pharmacology
Mahboubeh Setorki; Razieh Mahmoodi; Zahra Zanganeh nezhad
Volume 25, Issue 2 , May and June 2018, , Pages 293-301
Abstract
Introduction: Parkinson's disease results from degenerative loss of dopaminergic neurons in the substantia nigra and other part of the brain stem. Oxidative stress plays a major role in neuronal death in this disease. The aim of this study is to evaluate the effect of Biarum carduchrum extract in treatment ...
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Introduction: Parkinson's disease results from degenerative loss of dopaminergic neurons in the substantia nigra and other part of the brain stem. Oxidative stress plays a major role in neuronal death in this disease. The aim of this study is to evaluate the effect of Biarum carduchrum extract in treatment of Parkinson's disease.Methods: Rats were divided randomly into 5 groups of 8 animals. The control group did not receive any lesion. In Parkinson's group, Parkinson was induced by injection of 6- OHDA in the right anterior mid-brain (MFB). Third, fourth and fifth groups received Biarum carduchrum extract at doses of 100, 200 and 400 mg/kg via gavage for 14 days, 7 days after induction of Parkinson models. On day 15 behavioral tests, including catalepsy and open field was performed. Results: Parkinsonian group showed higher immobility time than control group in catalepsy test and rats treatment with Biarum carduchrum extract at doses of 200 and 400 dramatically reduce the immobilization time.Discussion: The results of this study show that Biarum carduchrum extract can improve motor impairment induced by Parkinson's, although didn’t significantly affect knowledge and anxiety in rats.
Mojtaba Akramian Fard; Amir Moghaddam Ahmadi; Fatemeh Ayyobi; Hasan Nakisa; Zahra Hadadian; Mohammad Shabani; Mohammadollah Tavakoli; Ali Shamsi zadeh
Volume 22, Issue 1 , March and April 2015, , Pages 36-44
Abstract
Background: Oxidative stresses have some role in neuronal pathogenesis in Substantia nigra and induction of Parkinson's disease. It has been reported that Achillea millefolium has antioxidant and nuoropropective effects. In this study, we investigated the effects of Aqueous extract of Achillea millefolium ...
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Background: Oxidative stresses have some role in neuronal pathogenesis in Substantia nigra and induction of Parkinson's disease. It has been reported that Achillea millefolium has antioxidant and nuoropropective effects. In this study, we investigated the effects of Aqueous extract of Achillea millefolium in a Parkinson’s diseases model induced by ICV injection of 6-hydroxydopamin in male rats.
Materials and Methods: In this experimental study, 60 male rats were allocated into 6 groups including Control, Parkinson’s and Parkinson’s groups which treated by different doses of extract. Parkinson’s was induced by i.c.v injection of 6-OHDA. Aqueous extract of Achillea millefolium (1.4 and 2.8 mg/kg) was gavaged by two ways including repeated gavage (14 days before and for 14 days after 6-OHDA injection) and acute gavage (once in day 13 after 6-OHDA injection). Parkinson’s was evaluated using Rotarod and Wire grasping tests on day 14 after 6-OHDA injection.
Results: The result of this study demonstrated that repeated gavage of Achillea millefolium extract improved motility and muscle tone following administration of 6-OHDA in rats (p