Physiology & Pharmacology
Jafar Ahmadpouri; saeid valipour chahardah charic; mahbubeh setorki
Volume 27, Issue 3 , September and October 2020, , Pages 475-482
Abstract
Introduction:Severe stressful incidents are associated with the risk of mental disorders such as depression and anxiety. Regarding the adverse effects of anti-depressants/anxiety drugs, researcher’s attention have been focused on finding natural ingredients. The aim of the present study was to ...
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Introduction:Severe stressful incidents are associated with the risk of mental disorders such as depression and anxiety. Regarding the adverse effects of anti-depressants/anxiety drugs, researcher’s attention have been focused on finding natural ingredients. The aim of the present study was to investigate the effect of Adiantum capillus veneris extract on depression and anxiety induced by acute stress in male rats.
Materials and Methods: In this experimental study, 40 male Balb/C mice were randomly divided into 5 groups including control group (under acute stress receiving normal saline), intervention groups (under acute stress receiving extract of Adiantum capillus venerisat doses of 100, 200 and 400 mg/kg), and positive control (under acute stress receiving diazepam). Acute stress was induced by electric shock (0.5 mA, 2 min) and immobilization in restrainer (2 hours) for one time. Extract and drug were administered intraperitoneally for 21 days and then anxiety, depression and Motor activity were evaluated by forced swimming, elevated plus maze (EPM) and open filed tests respectively.
Results: Treatment of stressed mice with different doses of Adiantum capillus veneris extractsignificantly decreased the immobility time in the forced swimming test in comparison with the control group (P <0.05). Treatment of stressed mice with 400 mg/kg of Adiantum capillus veneris extractsignificantly increased the entry into the open arms and significantly decreased the number of entery into the closed arms of EPM (P<0.05). Different doses of extract had no significant effect on the number of line-crossing in the open field test as compared with the control group.
Conclusion: Adiantum capillus veneris extract showed antidepressant and anti-anxiolytic effects in mice under acute stress.
Physiology & Pharmacology
Mahboubeh Setorki; Razieh Mahmoodi; Zahra Zanganeh nezhad
Volume 25, Issue 2 , May and June 2018, , Pages 293-301
Abstract
Introduction: Parkinson's disease results from degenerative loss of dopaminergic neurons in the substantia nigra and other part of the brain stem. Oxidative stress plays a major role in neuronal death in this disease. The aim of this study is to evaluate the effect of Biarum carduchrum extract in treatment ...
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Introduction: Parkinson's disease results from degenerative loss of dopaminergic neurons in the substantia nigra and other part of the brain stem. Oxidative stress plays a major role in neuronal death in this disease. The aim of this study is to evaluate the effect of Biarum carduchrum extract in treatment of Parkinson's disease.Methods: Rats were divided randomly into 5 groups of 8 animals. The control group did not receive any lesion. In Parkinson's group, Parkinson was induced by injection of 6- OHDA in the right anterior mid-brain (MFB). Third, fourth and fifth groups received Biarum carduchrum extract at doses of 100, 200 and 400 mg/kg via gavage for 14 days, 7 days after induction of Parkinson models. On day 15 behavioral tests, including catalepsy and open field was performed. Results: Parkinsonian group showed higher immobility time than control group in catalepsy test and rats treatment with Biarum carduchrum extract at doses of 200 and 400 dramatically reduce the immobilization time.Discussion: The results of this study show that Biarum carduchrum extract can improve motor impairment induced by Parkinson's, although didn’t significantly affect knowledge and anxiety in rats.
Physiology & Pharmacology
Zhaleh Noroozifar; Zahra Hoshmandi; Mahbubeh Setorki
Volume 24, Issue 3 , July and August 2017, , Pages 157-164
Abstract
Background & Objectives: Despite the numerous potential applications of nanoparticles in different sciences due to their unique properties, their adverse effects on human health have not been fully studied. The aim of this study was to evaluate the effects of Fe2O4Zn nanoparticle on thyroid and thyroid ...
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Background & Objectives: Despite the numerous potential applications of nanoparticles in different sciences due to their unique properties, their adverse effects on human health have not been fully studied. The aim of this study was to evaluate the effects of Fe2O4Zn nanoparticle on thyroid and thyroid hormones in male rats. Materials & Methods: Male Wistar rats were randomly divided into three groups: Control rats received 0.5 ml saline for 7 consecutive days. Group 1 and 2 rats received 0.5 ml of Fe2O4Zn nanoparticle solution at doses of 100 and 200 ppm, respectively. Injections were carried out intraperitoneally. Serum biochemical parameters were evaluated in rats, after 2, 7 and 14 days of beginning the experiment. On the 14th days, thyroid tissue was removed and used for histological assessment. Results: Administration of Fe2O4Zn nanoparticle in concentrations of 100 ppm and 200 ppm significantly decreased TSH levels compared with that of control samples (P<0.05), whereas no significant change in levels of T3 was observed (P>0.05). Fe2O4Zn nanoparticle treatments significantly increased serum levels of T4 (P<0.05). Nanoparticle treatments in view of textural properties showed severe blood, mild inflammation and larger follicle size and, by increasing the concentration of the nanoparticles, these effects were observed more severe. Conclusion: Due to the variations observed in the levels of thyroid hormones and the histological changes of thyroid tissue, it can be concluded that Fe2O4Zn nanoparticle had toxic effects on thyroid function. More studies to investigate the toxic effects of nanoparticles in different doses and different times of exposure to Fe2O4Zn nanoparticles seem to be necessary.