Effect of hydroalcoholic extract of Adiantum capillus veneris on depression and anxiety induced by acute stress in male mice

Ahmadpouri, Jafar; Valipour Chahardah Charic, Saeid; Setorki, Mahbubeh

Document Type : Original Article

Authors

¹ MSc, Department of biology, Izeh branch, Islamic Azad University, Izeh, Iran

² Assistant Professor of Animal Physiology, Department of Biology, Izeh branch, Islamic Azad University, Izeh, Iran.

³ Associate Professor of Animal Physiology, Department of Biology, Izeh branch, Islamic Azad University, Izeh, Iran

Abstract

Introduction:Severe stressful incidents are associated with the risk of mental disorders such as depression and anxiety. Regarding the adverse effects of anti-depressants/anxiety drugs, researcher’s attention have been focused on finding natural ingredients. The aim of the present study was to investigate the effect of Adiantum capillus veneris extract on depression and anxiety induced by acute stress in male rats.
Materials and Methods: In this experimental study, 40 male Balb/C mice were randomly divided into 5 groups including control group (under acute stress receiving normal saline), intervention groups (under acute stress receiving extract of Adiantum capillus venerisat doses of 100, 200 and 400 mg/kg), and positive control (under acute stress receiving diazepam). Acute stress was induced by electric shock (0.5 mA, 2 min) and immobilization in restrainer (2 hours) for one time. Extract and drug were administered intraperitoneally for 21 days and then anxiety, depression and Motor activity were evaluated by forced swimming, elevated plus maze (EPM) and open filed tests respectively.
Results: Treatment of stressed mice with different doses of Adiantum capillus veneris extractsignificantly decreased the immobility time in the forced swimming test in comparison with the control group (P <0.05). Treatment of stressed mice with 400 mg/kg of Adiantum capillus veneris extractsignificantly increased the entry into the open arms and significantly decreased the number of entery into the closed arms of EPM (P<0.05). Different doses of extract had no significant effect on the number of line-crossing in the open field test as compared with the control group.
Conclusion: Adiantum capillus veneris extract showed antidepressant and anti-anxiolytic effects in mice under acute stress.

Keywords

Main Subjects

Physiology & Pharmacology

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Journal of Sabzevar University of Medical Sciences

Effect of hydroalcoholic extract of Adiantum capillus veneris on depression and anxiety induced by acute stress in male mice

References

References

Volume 27, Issue 3
September and October 2020
Pages 475-482

Effect of hydroalcoholic extract of Adiantum capillus veneris on depression and anxiety induced by acute stress in male mice

References

References

Volume 27, Issue 3September and October 2020Pages 475-482

Volume 27, Issue 3
September and October 2020
Pages 475-482