Physiology & Pharmacology
mozhgan asghari; goudarz sadeghihashjin; aliakbar golabchifar; mohamad kazem koohi; ahad mohamadnejad; sanaz rismanchi; mohamad taheri
Volume 29, Issue 4 , September and October 2022, , Pages 502-516
Abstract
Introduction: In this study, we investigate the relationship between cancer and exposure to toxic substances in the environment. We used human encounters with them.Materials and Methods: In this experimental study, 60 adult male mice were divided into four groups, including control, Malathion, Malathion ...
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Introduction: In this study, we investigate the relationship between cancer and exposure to toxic substances in the environment. We used human encounters with them.Materials and Methods: In this experimental study, 60 adult male mice were divided into four groups, including control, Malathion, Malathion with benzene and benzene. The control group was tested only with physiological serum. Except for the benzene group, all other groups were in skin contact with Malathion for 45 days was fed. After necropsy, tissue samples were taken from the target organs. In addition, cytotoxicity was assessed by MTT and micronucleus tests in vitro and the percentage of IC50 was determined. Microscopic observations of liver tissue showed hepatotoxicity and renal tissue renal toxicity in the Malathion group with benzene.Results: The percentage of frequency of micronuclei at concentrations of 100 /g / ml, 50 /g / ml, 25 /g / ml was significant in all groups compared to the control group (P <0.05). In MTT test, the percentage of cell growth inhibition at concentrations of 100 g/ml, 50 g/ml, 25 g/ml, and 10 µg/ml in all groups was significantly different from the percentage of inhibition of cell growth with the control group (P < 0.05).Conclusion: According to the findings of this study, certain doses of Malathion alone and in combination with benzene cause cytotoxicity and pre-carcinogenicity in cytotoxicity tests. Malathion exacerbates the carcinogenic effects of benzene
nutrition
Rahman Armand; Mozhgan Asghari; mohsen armand; garshasp rigi
Volume 27, Issue 3 , September and October 2020, , Pages 314-319
Abstract
AbstractBackground: Aflatoxin M1 is produced by metabolizing aflatoxin B1 in the liver of the animal and is introduced into milk. Therefore, they are a threat to public health. The aim of this study was to investigate aflatoxin M1 in cow's milk and aflatoxin B1 in animal feed in Islamshahr.Materials ...
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AbstractBackground: Aflatoxin M1 is produced by metabolizing aflatoxin B1 in the liver of the animal and is introduced into milk. Therefore, they are a threat to public health. The aim of this study was to investigate aflatoxin M1 in cow's milk and aflatoxin B1 in animal feed in Islamshahr.Materials & Methods: In the winter of 1397, spring and summer of 1398, raw cow milk samples were collected from 5 livestock centers in each season. And 100 grams of feeds were taken, fed and taken to the laboratory for feed from livestock. The amount of aflatoxin was measured by ELISA. Data analysis was performed at the significant level of p