Authors
Abstract
Background: Diazinon (DZN) is an organophosphate (OP) that inhibit cholinesterase activity and induce oxidative stress in the target tissues such as the the reproductive system .The aim of present study was to evaluate the effects of diazinon on cholinesterase activity in blood serum and erythrocytes of male rats and to assess the protective role of vitamin E.
Material and Methods: In this experimental study, thirty adult male wistar rats (200 - 250 gr) were divided into 5 groups (n = 6): control group (did not receive any material), sham group (received only pure olive oil), experimental group 1 (DZN, 60 mg/kg), experimental group 2 (received DZN+Vit E daily, with the same dose) and experimental group 3(Vit E 200 mg/kg). DZN and solvent was injected intraperitoneally (IP) and vitamin E was administrated by gavage. After 6 weeks, 3 ml blood from the heart tissue was taken and titrimetric and Ellman’s method respectively was used for serum and erythrocyte cholinesterases activity evaluation. Data were analyzed using SPSS software. P
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