Authors
- Zahra Saneei
- Mariyeh Hosseinpour
- Ehsan Kazem Nejad Leili
- Anoush Dehnadi Moghadam
- Shahrokh Yosefzadeh Chabok
- Zahra Mohtasham Amiri
Abstract
Background: Damage caused by traumatic brain injury (TBI) depends on the extent of primary and secondary damages. The latter can cause induced neurological inflammation by releasing pro- and anti-inflammatory cytokines and chemokines. Measurement of serum interleukin-6 (IL-6), as a pro-inflammatory cytokine, can be useful in predicting outcome in patients with TBI.
Materials & Methods: In a cross-sectional study, 44 patients with GCS≤8 (Glasgow Coma Scale) and age ≥ 14 years, hospitalized in Poursina teaching hospital, were included in the study. Blood samples were collected from patients in the first 6 hours after the accident; and serum was tested by ELISA method for the determination of IL-6 levels. Patients' outcomes were recorded 6 months after head injury according to Glasgow Outcome Scale (GOS), and were divided in two good (GOS ≥4) and bad (GOS
Keywords
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