Authors
Abstract
Background: Many evidence showed that exercise training has beneficial effects on skin blood flow in the health and diabetic condition. On the other hand some finding showed that C-peptide has protective and therapeutic effect on vascular dysfunction-induced by diabetes. Therefore the purpose of this study is effects of resistance exercise on vascular function of C-peptide. Materials and methods: In this experimental study, Male wistar rats (220±10g, N=30) were used in two diabetic (control and trained) and one age-matched healthy control groups. After 1 week of diabetes induction, animals were submitted to resistance exercise training for 9
Weeks on ladder. To characterize cutaneous micro vascular responses by Laser Doppler
flowmetery, animals were deeply anesthetized by intraperitoneal injection of pentobarbital
sodium (50 mg/kg). For data analysis, one-way ANOVA test was used to compare the groups. Statistically significant difference between the minimum acceptable levels is p<0.05
Results: Local microinjection of c-peptide increased coetaneous blood flow in trained and control diabetic rats, however this effect in trained group is higher than control diabetic group rats. Administration of Nw-nitro-L-arginine (nitric oxide synthase inhibitor) before C-peptide reduced significantly C-peptide vascular effects in trained and control diabetic rats. Conclusions: Chronic resistance exercise potentiate C-peptide vascular function, possibly by nitric oxide pathway
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