Authors
Abstract
Background and purpose: Dopaminergic and glutamatergic systems play a critical role in expression of morphine-induced place conditioning, while vitamin C, released from glutamatergic neurons, modulates the synaptic action of dopamine and glutamate. This study investigated the effect of vitamin C on expression of morphine-induced place conditioning in male mice. Materials and methods: In this experimental study, 96 male NMRI mice (20-30g) were randomly divided into 12 groups of 8: control groups received normal saline (10 ml/kg) and treatment groups received morphine (2.5, 5, and 10 mg/kg) and vitamin C (1, 5, and 30 mg/kg) alone and with morphine. The study took place on six consecutive days, consisting of three phases: preconditioning, conditioning, and postconditioning. In the first set, vitamin C alone were administered in conditioning and postconditioning phases to see if they induced conditioned place preference (CPP) or aversion (CPA). In the second set, mice received vitamin C in postconditioning phase after conditioning with morphine. Results: Different doses of morphine (5 and 10 mg/kg, p
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