Authors
Abstract
Background and objective: Kelussia odoratissima Mozaffarian (Umbelliferae family) is one of the Iranian medicinal plants that has nutritional and pharmacological effects. In Iranian traditional medicine, it has been mentioned that this plant has anti-spasmodic effect and it is used for the treatment of gastrointestinal dysfunctions, such as abdominal pain. In this study, we evaluated the effect of alcoholic extract of Kelussia odoratissima Mozaffarian on ileum contractions in rats. Method: Alcoholic extracts were prepared from powdered Kelussia leaves. Ileum samples were placed in an organ bath containing tyrode solution and 1g tension was used before inducing ileum isotonic contraction with KCl (60 mM). Saline or extracts (10% and 20%) were added to the bath and responses were recorded. Data were analyzed using ANOVA followed by Tukey HSD test. Findings: Our results demonstrated that both concentrations of Kelussia significantly reduced the KCl-induced contraction in isolated rat ileum compared to the control (saline) group (p
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