Authors
Abstract
Background: Minocycline is an antibiotic and anti-inflammatory drug. In addition, its neuroprotective effects have been shown. Since there is interaction between cell death and seizure, the aim of this study is examination of the role of minocycline on amygdala-kindled seizures in rat.
Materials and Methods: In this experimental study, three groups of animals (18 rats), after stereotaxic surgery and 1-week recovery period, received twice daily kindling stimulations. In fully kindled animals of groups 1-3, minocycline was injected intraperitoneally in doses 12.5 (n = 7), 25 (n = 5) and 50 (n = 6) mg/kg, respectively, 60 minutes before stimulation. Afterdischarge duration (ADD), stage 4 latency (S4L), Stage 5 Duration (S5D) and Seizure Duration (SD) were recorded and compared with related control groups (the same animals that had received saline 1 day before). A p-value of less than 0.05 was considered to represent a significant difference.
Results: In fully kindled animals who had received minocycline (50 and 25 mg/kg), ADD decreased significantly. When minocycline was delivered, S5D decreased 38.3% (p < 0.001), 34% (p
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