Document Type : Original Article

Authors

• Vahideh MoghaddamHosseini ¹
• abolfazl Kargari ²
• Najme Rahimi ³
• Nazanin Fekri ⁴
• Roghayeh Javan ⁵

¹ Assistant Professor, Ph.D. of Reproductive Health, Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.

² Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.

³ Assistant professor of Endocrinology.Non communicable disease research center. Sabzevar University of sciences. Sabzevar. Iran.

⁴ Assistant Professor, Department of Biostatistics, School of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran

⁵ Non communicable Disease Research Center. Sabzevar University of sciences. Sabzevar. Iran.

Abstract

Background and Objectives: Hypothyroidism is one of the most common endocrine disorders, particularly in women. It is associated with metabolic alterations, including dyslipidemia. Beyond its classical role in bone metabolism, vitamin D also regulates metabolic and inflammatory processes. This study aimed to investigate the association between vitamin D level and lipid profile in women with hypothyroidism.

Materials and Methods: In this analytical cross-sectional study, 92 women who were newly diagnosed and attending an endocrinology subspecialty clinic in Sabzevar were selected through convenience sampling. obtaining informed consent,, demographic information was recorded, and serum vitamin D and lipid profile levels were measured. Data were analyzed using SPSS version 26 and the Kolmogorov–Smirnov test, Spearman correlation, and multivariable linear regression.

Results: The mean age of participants was 40.52 ± 10.48 years. The mean vitamin D level was 22.29 ± 8.24 ng/mL, and 82.6% of women with hypothyroidism had vitamin D levels below the sufficiency threshold. Vitamin D level was significantly associated with HDL-C (r = 0.287, P = 0.007). This association remained significant after adjustment for age,, BMI, and TSH (B = 0.329, P = 0.007). No significant association was found between vitamin D and total cholesterol, triglycerides, or LDL-C (P > 0.05).

Conclusion: The frequency of vitamin D deficiency was high among women with hypothyroidism. After adjustment for confounding variables, vitamin D level showed a significant direct and independent association only with HDL-C. This finding emphasizes the need to consider vitamin D status in the cardiovascular risk assessment of these patients.

Keywords

• Hypothyroidism
• Vitamin D
• Lipid profile
• HDL-C

Main Subjects

• Internal Medicine