Document Type : Original Article
Authors
1 GP. School of Medicine, Pardis branch, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 PhD in Medical Virology. Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Professor in Medical Virology. Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4 Associate Professor in Medical Virology. Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Abstract
Background: Knowledge regarding prevalence of Hepatitis E Virus (HEV) can be an indicator of the public health and hygiene. HEV is the main cause of acute hepatitis in adult patients. Although the main route of its transmission is through the fecal-oral route, reports have been published about the transmission of this virus through blood transfusion. This study aimed to determine seroepidemiology of hepatitis E virus among thalassemia major patients in Ahvaz, Iran.
Materials and Methods: In this descriptive cross-sectional study, 88 patients with beta-thalassemia major admitted to Shafa Clinic in Ahvaz, Iran, to receive blood monthly in a period of 6 months in 2018, were included in the study. An ELISA kit was used to detect anti HEV IgM and IgG Ab. RT-PCR was used for RNA detection from all samples. The obtained data were statistically analyzed.
Results: Out of 88 patients, 10 (11.36%) were positive for HEV IgG; and the prevalence of HEV IgM was determined in 6 patients (6.81%) with the ELISA method. RT-PCR showed that none of the samples contained the virus. There were no significant relation between anti HEV Ab and variables such as age and gender. There was a significant association between HEV infection and frequency of blood transfusion (P = 0.02).
Conclusion: In this research, despite the absence of the virus in the blood, patients had hepatitis and were likely to transmit the virus through infected blood. The prevalence of the HEV in the study population is high, showing that the infection is endemic in the community.
Keywords
- Hepatitis E virus
- Immunoglobulin M
- Immunoglobulin G
- Prevalence
- Enzyme-Linked Immunosorbent Assay
- Beta-Thalassemia
Main Subjects
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