Document Type : Original Article
Authors
- Hamid-Reza Sadoughi 1
- Pooya Vahabi-Nasiri 2
- Parastoo Amiri 3
- Seyed Alireza Javadinia 3
- Ruhollah Ghahramani-Asl 4
1 Department of Medical Physics and Radiology, Faculty of Paramedicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
2 General Practitioner, Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3 Assistant Professor, Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
4 Non-Communicable Diseases Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran Department of Medical Physics and Radiological Sciences, Faculty of Paramedicine; Sabzevar;Iran
Abstract
Background: External beam radiotherapy is a cornerstone in the management of rectal cancer. Due to the anatomical proximity of critical pelvic structures to the radiation fields, accurate dosimetry is essential. This study aimed to quantify and analyze the radiation dose delivered to healthy organs in patients with rectal cancer undergoing beam radiotherapy.
Materials and Methods: In this retrospective cross-sectional study, we analyzed the dosimetric records of 66 patients with rectal cancer treated at Vasei Hospital Radiotherapy Department in Sabzevar between 2019 and 2021. Demographic data and dosimetric parameters —including the mean and maximum equivalent dose in 2-Gy fractions (EQD2) to the clinical target volume (CTV), planning target volume (PTV), and organs at risk (bladder, femoral heads, penile bulb)— were extracted from the IsoGray treatment planning system. Data were analyzed using SPSS v22 with independent t-tests, Pearson correlation, and ANOVA.
Results: The mean radiation doses to the organs at risk (OAR) were as follows: bladder, 47.96 ± 5.83 Gy; left femoral head, 26.40 ± 6.68 Gy; right femoral head, 25.66 ± 7.40 Gy; and penile bulb, 17.75 ± 13.27 Gy. Although femoral head doses were higher in males and bladder doses in females, these differences were not statistically significant. A weak positive correlation was observed between patient age and penile bulb dose. No significant association was found between BMI and OAR doses.
Conclusion: Demographic variables did not significantly influence dose distribution to adjacent healthy organs. Treatment planning should emphasize tumor anatomy and the adoption of advanced radiotherapy techniques for optimal dose conformity and organ sparing.
Keywords
Main Subjects
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