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Study of the Incidence of Bisphosphonate-Related Osteonecrosis of the Jaw in Chemotherapy Patients in Qom, Iran until 2024

Document Type : Original Article

Authors

1 Study of the Incidence of Bisphosphonate-Related Osteonecrosis of the Jaw in Chemotherapy Patients in Qom, Iran until 2024

2 Dentist of Students' Research Committee (SRC), Faculty of Dentistry, Qom University of Medical Sciences, Qom, Iran

3 PhD. Information Retrieval, Researcher of Spiritual Health Research Center, Qom University of Medical Sciences, Qom, Iran

Abstract

Background: The use of bisphosphonates, anti-adsorption and anti-angiogenic drugs during the treatment process of chemotherapy patients can increase the likelihood of developing Bisphosphonate-Related Osteonecrosis of the Jaw. The present study was conducted to determine the percentage of lesion incidence in different areas of the jaw considering the duration and type of chemotherapy drugs used.
Materials and Methods: In this cross-sectional study, a total of 749 files of patients aged 18-92 years were coded and selected by simple random sampling, considering the inclusion criteria. Patients with a mean age of 56.05 ± 13.85 years were selected using simple random sampling, considering inclusion criteria and variables such as cancer diagnosis type, presence or absence of metastasis, etc. The extracted data were analyzed using SPSS version 22.
Results: The highest frequency of patients with different types of cancer was related to breast cancer with 301 patients and the average duration of treatment was 1.12 ± 0.46 years. The highest frequency in terms of drug use in patients was related to Alendronate with 391 patients; and 45 patients had metastases. No significant relationship was observed between the association of BRONJ incidence with different variables, but a significant association was observed between the BRONJ incidence, the severity of the disease and the location of BRONJ.
Conclusion: The incidence of BRONJ in the patients, the severity of bronzing and its area can vary. The highest incidence of BRONJ was in the posterior jaw area; and its incidence decreased with increasing disease grade.

Keywords

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References
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Journal of Sabzevar University of Medical Sciences
Volume 33, Issue 1
March and April 2026
Pages 757-767
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History
  • Receive Date: 17 March 2025
  • Revise Date: 30 September 2025
  • Accept Date: 03 September 2025
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