Document Type : Original Article
Authors
- Kazem Abbaszadeh goudarzi 1
- Zahra Moradi 2
- Mahdi Tadayonfar 2
- Mahsa Asghari 3
- Maryam Nabavifard 3
- Amir Raoofi 4
- Roghayeh Zardosht 5
- Saeideh sadat Shobeiri 6
- Mohammad Shafi Mojadadi 7
1 Department of Medical Biotechnology, Faculty of Advanced Technologies in Medical Sciences, Golestan University of Medical Sciences, Gorgan, Iran.
2 Student Research Committee, Sabzevar University of Medical Sciences, Sabzevar, Iran.
3 Clinical Research Development Unit, Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran.
4 Associate Professor, Department of Anatomy, Sabzevar University of Medical Sciences, Sabzevar, Iran.
5 Associate Professor, Department of operative room and anesthetics, Iranian Research Center on Healthy Aging. School of paramedical, Sabzevar University of Medical Sciences, Sabzevar, Iran
6 Assistant Professor, Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
7 Associate Professor of Immunology, Department of Microbiology, Leishmaniasis Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Abstract
Introduction: Serum cortisol concentration correlates with anti-spike antibody levels in vaccinated individuals, suggesting cortisol may be a marker of vaccine immunogenicity. This study aimed to investigate the relationship between serum cortisol levels and anti-SARS-CoV-2 spike protein antibody response following vaccination.
Materials and Methods: In this cross-sectional study, 80 staff members from Sabzevar University of Medical Sciences who had received a second dose of either the Sinopharm or Sputnik V vaccine were included. Serum cortisol and anti-spike IgG antibody levels were measured using enzyme-linked immunosorbent assay (ELISA). Data were analyzed with SPSS version 22, employing ANOVA and Pearson's correlation.
Results: The mean age of participants was 34.81 ± 7.62 years. Significant differences were found in both anti-spike IgG titers and serum cortisol levels based on vaccine type (P < 0.001). Recipients of the Sputnik V vaccine demonstrated significantly higher antibody levels (mean ± SD: 138.2 ± 65.1 AU/mL) and cortisol levels (7.8 ± 2.5 µg/dL) compared to Sinopharm recipients (69.0 ± 60.3 AU/mL and 5.1 ± 1.8 µg/dL, respectively). No significant differences in antibody or cortisol levels were observed based on age or gender. Furthermore, no significant correlation was found between individual serum cortisol concentration and anti-spike IgG titer (P > 0.05).
Conclusion: While the type of COVID-19 vaccine was associated with differing levels of both antibody response and serum cortisol, no direct correlation was established between serum cortisol concentration and anti-SARS-CoV-2 spike protein IgG antibody titer
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