Document Type : Original Article
Authors
- Hessamedin Babaei 1
- Mahtab Ghasemi 1
- Aref Arminfar 1
- Leila Khojasteh 2
- Shiva Shabanzadeh 2
- Soheil Shahrami Rad 1
- Afagh Zamen Ghadirli 2
- Behrooz Yahyaei 2
1 Student Research Committee, Shahrood Branch, Islamic Azad University, Shahrood, Iran
2 Department of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran
Abstract
Background: One of the common drugs used in modern anesthesia, especially during pregnancy, is ketamine, which is used to control chronic pain by inhibiting the N-methyl-D-aspartate receptor. Therefore, in this study, we investigate the effects of injected ketamine on the histological changes of the hearts of rats born to exposed mothers.
Method: This study was conducted as a laboratory experiment on 15 female Wistar rats. These rat were divided into three groups of 5 including control, short-term and long-term groups, and after induction of fertility, 10 baby rats were randomly selected from each group and subjected to cardiac tissue dissection and sampling.
Results: In the short-term dose group, cellular characteristics and heart tissue were normal, and no clear changes were observed compared to the control group, but in some areas, there were small intercellular spaces with a decrease in density. In the long-term dose group, a slight inflammatory process was seen in some areas, but there were no changes in the cells, cytoplasm, and nuclei.
Conclusion: Although the long-term exposure of mother rat to ketamine can cause mild inflammation and moderate hyperemia in the heart tissue of newborn rat, and the short-term exposure of mother rat to ketamine causes mild changes in heart muscle tissue like long-term exposure but these changes have not been noticeable.
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