Document Type : Original Article
Authors
department of biostatistic , medical school, Arak university of medical sciences , Arak , Iran
Abstract
Background: Congenital Hypothyroidism is one of the most prevalence disease of endocrinology and metabolic infant and important caused of mental deficiency. Hypothyroidism in the secondary causes represented by problem in pituitary or hypothalamus and shortage of TSH . clinical symptom of Hypothyroidism at the first days of birth are indiscernible so only way of diagnosis and treatment of that, is screening. In this study we used the bootstrap method to evaluation the ROC curve of diagnostic screening TSH test.
Materials and Methods: in this study A bootstrap method is proposed to plot ROC curve and determinate the cut point of TSH & T4 based on YOUDEN method. at the first generated subsample and estimated ROC and cut-off point for each sample. the procedure run for 500 replicate. for each replicate selected cut-off where have maximum YOUDEN. The cut-off point calculated for 500 replications from each sample and then selected mean of 500 replicate. The cut-off which have minimum misclassification selected optimal cut-off point.
Results: based ordinary method to estimate the ROC curve the optimal cut-off point for TSH variable is 10MU/L and for T4 variable is 100MU/DL which based the bootstrap method respectively optimal cut-off point for TSH is 9.54 and for T4 is 101.5.
Conclusion: the optimal cut-off point where obtained from bootstrap method have minimum misclassification rate versus ordinary method. based the small sample bootstrap have minimum misclassification rate toward ordinary method with large sample.
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