Document Type : Original Article
Authors
1 Master student of Medical Physiology, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Iran
2 Associate Professor, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Iran
3 Professor of Physiology, Department of Physiology and Pharmacology, Faculty of Medicine, Sabzevar University of Medical Sciences, Iran
4 Assistant Professor, Department of Traditional Medicine, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
5 Professor of Physiology, Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Iran
Abstract
Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental syndrome with two main symptoms: repetitive behavior and social interaction disorder. Camel milk, due to its antioxidant, immune-modulating, anti-inflammatory, and anti-apoptotic properties maybe have beneficial effects on ASD.
Materials and Methods: Pregnant rats were injected intraperitoneally on day 12.5 of gestation with 500 mg/kg valproic acid. Then male neonatal rats were divided into five groups: Control group, valproic acid group, camel raw milk group + risperidone, and boiled camel milk group + risperidone. For the treatment period, rats have injected with risperidone (0.2 mg/kg) three times a week, and raw and boiled camel milk was given daily (10 ml/kg) for 42 days. Experiments of social interaction and repetitive behavior were measured at the beginning and end of the treatment period.
Results: The offspring of mothers who received valproic acid had problems in social interactions, and sociability and social preference indexes were significantly reduced. Repetitive self-glooming behaviors also increased in VPA-rats. The treatment groups improved their social and repetitive behaviors after receiving camel milk and risperidone and were significantly different from the valproic acid and pre-treatment groups. Moreover, sociability and social preference indexes showed an increase after treatment with camel milk. Sociability index, social preference, social preference index, and repetitive behaviors before and after treatment between groups improved significantly (p <0.001) after treatment.
Conclusion: Treatment with a camel milk diet improved the main behaviors of autism symptoms, such as social interactions and repetitive movements
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Main Subjects
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