Document Type : Original Article
Authors
1 Assistant professor of Department of Medicine, Faculty of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran
2 Graduated in general medicine, Faculty of Medical Sciences, Shahrood Branch, Islamic Azad University, Shahrood, Iran
Abstract
Background: Due to the effect of L-arginine analogues on inhibiting nitric oxide synthesis and exercise training as one of the non-pharmacological methods, the aim of this study was to evaluate the effect of aerobic exercise training with garlic extract on changes of cerebellar tissue in rats with induced hypertension.
Materials & Methods: Rats weighing 200 to 220 gr and hypertension at 10 to 12 weeks of age responding to the main symptoms of hypertension were selected. The rats will be divided into 6 treatment groups after a period of injection of L_NAME that results in hypertension. Balance and motor coordination test was performed after 8 weeks of exercise using Beam Walking Test. The treatment groups were given orally garlic and sorbide extracting.
Results: In the hypertensive group, white matter and gray matter had some amount of hypertension associated with cellular distribution in the granular area. In Purkinje cells, degenerative cellular changes are observed.
Endurance training group did not show any significant changes compared to control group. The endurance training group and the garlic extract retained some meningeal detachment along with some blood accumulation, and the sorbide group in the purkinje cells degenerative changes such as bold cytoplasm and unspecified nucleus are seen.
Conclusion: Hypertension causes moderate changes in the purkinje layer and mild changes in the granular layer, as well as mild hyperemia in the cerebellar tissue and the sorbide and garlic extract alone, as well as markedly reduced exercise training.
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- Loscasio J, Kasper D,Fause Ar, Longo D. Harrison's principles of internal medicine: 2012, 17Th edition.
- Movayed SM, Rohani H, Eghtedar Doost M. Evaluation of the effect of Allium sativum aqueous extract on serum nitric oxide in mice. Daneshvar Medicine, 2020; 22(6): 35-44.
- Jafari H, Abbassi A, Miri S, Shahidi M. Effect of Allium sativum L. aqueous extract on contraction power of isolated atrium from rats following administration of adrenaline. Journal of Inflammatory Diseases. 2006; 9(4): 25-29.
- Masuod-Hamidi E, KHaksari M, Hojabri K. The Effects of Aqueous Extracts of Echium Amoenum and Citrus Aurantiflia on Blood Pressure and Heart Rate before and after phynelephrine Injection in Rat. Journal of Kerman University of Medical Sciences. 2011; 18(4): 349-357.
- Noori MM, Minaei B, Mehranniya T, Azarniya M, Shirazi R, The effects of L-Arginine and L-Name on corpus luteum and growing follicle changes in pregnant rats. SJIMU. 2010; 17(4): 1-8.
- Rahimi M, Vafaee F, Shafei M, Niazmand S, Khajavi-Rad A, Amani , Hosseini M. The effects of increased blood pressure induced by phenylephrine on Morris water maze tasks in male and female rats. JNKUMS. 2012; 4 (3): 363-371.
- Naserpur F, Esmaeili H, Momeni A, Abasi A, Jafari H, Jahani HH. The impact of hydro-alcoholic extract of garlic on depression induced by rezrepin in rats. Iranian Journal of Neurology, 2009; 8(26-27): 527-534.
- Hosseiny S, Farahani Z, Shiri H, AbedSaeidi Z, AlaviMajd H, Hamidizadeh S. The effects of low intensity aerobic exercise on blood pressur. J Shahrekord Univ Med Sci. 2007; 9(2): 14-19.
- Saadati H, Babri S, Ahmadiasl N, Mashhadi M. Effects of Exercise on Memory Retrieval in Passive Avoidance Learning in Young Male Wistar Rats. Qom Univ Med Sci J. 2009; 3(1): 41-48.
- Curtelin D, Morales-Alamo D, Torres-Peralta R, Rasmussen P, Martin-Rincon M, Perez-Valera M, Siebenmann C, Pérez-Suárez I, Cherouveim E, Sheel AW, Lundby C, Calbet JA. Cerebral blood flow, frontal lobe oxygenation and intra-arterial blood pressure during sprint exercise in normoxia and severe acute hypoxia in humans. J Cereb Blood Flow Metab. 2018; 38(1): 136-150.
- Hosseiny S, Farahani Z, Shiri H, AbedSaeidi Z, AlaviMajd H, Hamidizadeh S. The effects of low intensity aerobic exercise on blood pressur. J Shahrekord Univ Med Sci. 2007; 9(2): 14-19.
- Safiriyu A, Semuyaba I, Remón F, Etibor T. Ajibola M. Garlic Extract (Allium sativum) Enhances Spatial Working Memory in Wistar Rats: Involvement of Hippocampal Na+/K+ ATPase and Ca2+ ATPase Activities. Journal of Behavioral and Brain Science. 2017; 7: 31-40.
- Jafari H, Abbassi E, Miri SR, Shahidi M. Effect of Allium sativum L. aqueous extract on contraction power of isolated atrium from rats following administration of adrenaline. J Qazvin Univ. Med. Sci. Health Serv. 2006; 9(4): 25-29.
- Bashiri J. The effect of regular aerobic exercise and garlic supplementation on lipid profile and blood pressure in inactive subjects. Zahedan J Res Med Sci. 2015; 17(4): 2-6.
- Yahyaei B, Varmazyar Sh. Investigation of effects of Methylphenidate and endurance exercise on structural changes in brain tissue of male rats with hyperactivity. Jorjani Biomedicine Journal. 2021; 9(2): 45-54.
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