Biotechnological Carotenoid Production by Rhodotorula mucilaginosa and Study of Its Effect on Lipid Profile in Male Mice

Karimiyan, Fatemeh; Madani, Mahboobeh; Naghsh, Noshin

Document Type : Original Article

Authors

¹ Master student of Biotechnology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

² Associate Professor, Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

³ Associate Professor, Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Abstract

Introduction: Today, carotenoids draw attention because of their antioxidant and antitumor properties and also usage as natural food colors. In this study, the biotechnological production of carotenoid by the yeast Rhodoturola musilaginosa and its effect on the lipid profile of male mouse were investigated.
Materials and Methods: In this semi-experimental study, carotenoids were extracted from R. mucilaginosa using the Davis method. Twenty four male mice were randomly divided into four groups of six each. Two treatment groups received 16 and 32 mg/kg carotenoid peritoneally. One group received 400 mg/kg R. mucilaginosa powder by gavage. Control group received 0.5 ml physiological serum intraperitoneally. Blood samples were then collected and lipid profile was studied for triglyceride, cholesterol, LDL and HDL. The results were analyzed by SPSS 21 and comparisons were conducted using one-way ANOVA and Kruskal-Wallis test.
Results: The lowest serum concentrations of triglyceride and VLDL were observed in the group given 32 mg/kg carotenoid compared to the gavage and control groups. Mean serum cholesterol and HDL concentrations in the groups were not significantly different. The highest mean LDL concentration was observed in the gavage group.
Conclusion: According to the results of this study, R. muscilaginosa carotenoid decreased serum concentrations of triglyceride, VLDL and cholesterol. Therefore, it seems that the possibility of using it as a dietary supplement be helpful.

Keywords

Main Subjects

Biotechnology & nanotechnology

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Journal of Sabzevar University of Medical Sciences

Biotechnological Carotenoid Production by Rhodotorula mucilaginosa and Study of Its Effect on Lipid Profile in Male Mice

References

References

Volume 28, Issue 4
September and October 2021
Pages 545-555

Biotechnological Carotenoid Production by Rhodotorula mucilaginosa and Study of Its Effect on Lipid Profile in Male Mice

References

References

Volume 28, Issue 4September and October 2021Pages 545-555

Volume 28, Issue 4
September and October 2021
Pages 545-555