Comparative evaluation on the Effect of Phenytoin Ointment, Aloe Vera Gel, Royal Jelly and Honey on Wound Healing in the Animal Model of Rabbit: Histopathological and Macroscopic Evaluation

Razavi, Seyed Arman; Bigham-Sadegh, Amin; Karimi, Iraj; Sharifi, Siavash; Hafar, Iman

Document Type : Original Article

Authors

¹ 1. Graduated DVM, Private clinician, Langrod City. Langrod, Iran

² Professor, Department of Veterinary Surgery and Radiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran

³ Associate Professor, Department of Veterinary Pathobiology, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran

⁴ Assistant Professor, Department of Veterinary Surgery, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran

⁵ Graduated DVM, Private clinician, Yazd City, Yazd, Iran

Abstract

Introduction: Phenytoin ointment is a usual medicine for wound healing. Aloe vera gel promotes wound healing by directly stimulating the activity of macrophages and fibroblasts that increase both collagen and proteoglycan synthesis, thereby promoting tissue repair. The aim of this study was to evaluate the effects of phenytoin ointment1%, aloe vera gel, royal jelly and honey on skin wound healing in rabbit animal model.
Materials and Methods: 5 rabbits with 50 skin wounds were used in this study. Phenytoin ointment1%, aloe vera gel, royal jelly and honey were used in four wounds and another was considered as an untreated control. Macroscopic study was performed on days 4, 8, 12, 16 and 20 after wounding and histopathologic study was done on the days 10 and 21 from the wounds.
Results: On the 8^th and 12^th days in the Aloe vera gel, royal jelly and honey groups, the area of the wound had a significant difference (p < 0.05) than group1 (phenytoin), indicating a faster reduction of the wound surface than the phenytoin group. On the 16^th day after surgery, the ulcer surface of the honey group was completely closed and on day 20 all the wounds were fully restored in all groups. Also, histopathologic studies on 10 and 21 days showed no significant difference between the studied groups and all wounds were completely restored on day 20.
Conclusion: Finally, the results of this Study showed that phenytoin 1% ointment, aloe vera gel, royal jelly and honey, all had a good effect on wound healing.

Keywords

Main Subjects

Physiology & Pharmacology

References

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Journal of Sabzevar University of Medical Sciences

Comparative evaluation on the Effect of Phenytoin Ointment, Aloe Vera Gel, Royal Jelly and Honey on Wound Healing in the Animal Model of Rabbit: Histopathological and Macroscopic Evaluation

References

References

Volume 28, Issue 3
May and June 2021
Pages 387-395

Comparative evaluation on the Effect of Phenytoin Ointment, Aloe Vera Gel, Royal Jelly and Honey on Wound Healing in the Animal Model of Rabbit: Histopathological and Macroscopic Evaluation

References

References

Volume 28, Issue 3May and June 2021Pages 387-395

Volume 28, Issue 3
May and June 2021
Pages 387-395