Authors
Abstract
Background and Purpose: Cuminum Cyminm (CC) is one of the plants whose aqueous extract is used in traditional medicine as anti-convulsive anti-epileptic and as a treatment for some visceral pains. However no substantial reports can be found of its effects on the peripheral pain in lab animals. Therefore this study was condcated to determine the effects of the IP injection of the aqueous extract of CC on the acute peripheral pain in Hot Plate (HP) and Tail Flick (TF) tests in mice.
Methods and Materials: This experimental study was conducted on 56 male Albino mice (8 groups each with 7 mice) weighing 25-30 gr. 200 and 500 mg/kg of the aqueous extract of CC or saline of the volume were injected intraperitoeally 30 minutes prior to the tests. Pain measrment criteria in the TF test was the response time to the pain by raising the tail and in the HP test the time to begin to lick the front legs or raising the rear feet.
Results: The IP injection of the CC aqueous extract with the doses of 200 and 500 mg/kg significantly increased the response time to the pain in HP and TF tests (P
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