Clinical effectiveness of Glucosamine compared to Chondroitin sulfate، hyaluronic acid on relieving pain in people with osteoarthritis: a network meta-analysis

Kord Varkaneh, Hamed; Salehi, Ammar; Khani, Vahid; Zarezade, Meysam; Khorshidi, Masoud; Rahmani, Jamal; Mosavi, Mohammad; Fatahi, Somaye

Document Type : Review article

Authors

¹ Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

² Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid

³ School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran

⁴ Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

⁵ Students’ Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran

Abstract

Abstract: So far, no study has ever surveyed the effectiveness of injectable and oral forms of the Glucosamine compared with chondroitin sulfate and hyaluronic acid on physical function and pain in osteoarthritic patients. The aim of this study is to evaluate the clinical efficacy of glucosamine compared with chondroitin sulfate and hyaluronic acid in relieving pain and function of people with osteoarthritis.
Design: The databases of PubMed, Scopus, Google Scholar and Cochran were searched up to November 2018. The pairwise method was used to compare the difference between the mean score of the evaluation forms before and after the intervention in two methods including direct (comparison of drugs with the control group) and non-direct (comparison of drugs with each other).
Results: The present study showed that improvement in the performance of patients with osteoarthritis according to the WOMAC score, was the highest with oral form of chondroitin sulfate and then the injectable form of chondroitin sulfate and injectable form of glucosamine. Pain evaluation of patients showed the most pain reduction in the injectable form of hyaluronic acid and then the oral form of chondroitin sulfate. Pain assessment via the VAS form, showed that oral form of glucosamine alleviated the pain.
Conclusions: This study demonstrated that, intake of oral form of chondroitin sulfate had the most effect on improving the physical function. Also, in the assessment of pain using WOMAC and VAS forms, the injectable form of hyaluronic acid and oral form glucosamine showed the highest improvement compared to other drugs.

Keywords

Main Subjects

Physiology & Pharmacology

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Journal of Sabzevar University of Medical Sciences

Clinical effectiveness of Glucosamine compared to Chondroitin sulfate، hyaluronic acid on relieving pain in people with osteoarthritis: a network meta-analysis

References

References

Volume 27, Issue 2
July and August 2020
Pages 246-255

Clinical effectiveness of Glucosamine compared to Chondroitin sulfate، hyaluronic acid on relieving pain in people with osteoarthritis: a network meta-analysis

References

References

Volume 27, Issue 2July and August 2020Pages 246-255

Volume 27, Issue 2
July and August 2020
Pages 246-255