Document Type : Original Article
Authors
- Mahdi Mirhamidi 1
- Atefeh Asadi 2
- Mahbobeh Nematshahi 3
- Mohammad nematshahi 4
- Manijeh Yousefi 5
- Davood Sourosh 6
- Ali Tajabadi 7
- Adeleh Abdolalizadeh 8
- hossein fahimi 9
1 Department of Orthopedics, Faculty of Medicine, Sabzevar University of Medical Sciences
2 General Physician, Deputy of Health of Sabzevar University of Medical Sciences, Medical center
3 Social Medicine Specialist, Statistics Advisor, Sabzevar University of Medical Sciences
4 Assistant Professor of Anesthesiology, Faculty of Medicine, Sabzevar University of Medical Sciences.
5 Assistant Professor of Anesthesiology, Faculty of Medicine, Sabzevar University of Medical Sciences
6 Assistant Professor of Poisoning, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
7 Assistant Professor of Nursing, Faculty of Nursing, Sabzevar University of Medical Sciences, Sabzevar, Iran
8 Medical Student, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
9 Department of Psychiatry, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
Abstract
Abstract:
Thiopental Sodium is a commonly used drug in anesthesia, but it is not ideal because barbiturate is prohibited in acute and allergic porphyria, and is not recommended in asthmatic and hypovolemic patients. Propofol is the newest drug in anesthesia due to its rapid onset, short duration of action, anti-nausea and a feeling comfort after use, its consumption is increasing. It is also safe in porphyry and asthma. This study compares the use of sodium antiproliferative drug propofol to reduce the need for opiate.
Analysis Method:
This study was conducted on 173 patients admitted to Sabzevar Hospital. Patients were randomly divided into two study and control groups. Anesthesia induction was performed in the study group with propofol 2. 2 kg / mg and with thiopental sodium 5 kg / mg, in both groups, blood pressure and heart beats were measured before and after induction and minutes 1, 5 and 11 after intubation. Within 1-2-3-4 hours after operation with a pain control chart, the intensity of the pain was checked and the data were recorded.
Findings:
In the propofol group at the 4th hour, 44 individuals feel mild pain, and 9 had moderate, but severe pain was not reported(P=0/44). In the thiopental group at the fourth hour, 53 patients feel mild pain, 11 had moderate and 5 had severe pain.(P=0/44)
Conclusion:
Propofol increases the threshold of postoperative pain, so it can be a good alternative to thiopental.
Keyword: Thiopental, Propofol, Opiate
Keywords
Main Subjects