Effect of Theranekron General Infusion on Tendon Repair in Rabbit by Ultrasonography and Histopathology

Yadegari, Mehrdad; Bigham-Sadegh, Amin; Saberi, Ali; Parvizi, Ali; Moghtadaiee-Khorasgani, Elham

Document Type : Original Article

Authors

¹ Department of Diagnostic Surgery and Imaging, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

² Department of Veterinary Surgery and Radiology, Shahrekord University, Shahrekord, Iran.

³ Graduated in Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

⁴ Department of Pathobiology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

Abstract

Introduction:Tendon rupture is one of the most common problems in livestock and human. Tendon has a special blood flow network that is fed from outside to inside. The most important factor in tendon healing is blood flow which is very slow. Various methods that have been implemented to treat and repair these raptures are time-consuming.
Materials and Methods: 10 male New Zealand rabbits with weight 1-2/5 kg were selected and kept for one month. The posterior organs of the rabbits were shaved and anesthetized. Then, under sterile conditions, the SDFT tendon was cut through the skin, the rabbits were divided into two groups of five and the control group and received three groups of samples at a dose of 1μg/kg of Theranekron, and during the days of 3, 10 And 30 ultrasound examinations. After 30 days, the samples were euthanasia for pathological investigations, and the lesion was removed and sent to the lab.
Results: The results of the thirtieth day of ultrasound examination showed a significant improvement in the tendon fibroblasts, similar to the normal area of the damaged region of echogenicity. Histopathologic results show the beneficial effects of Theranekron during this study. Therefore, the number of collagen fibers accumulated in the tissue in the treated group significantly increased.
Conclusion: It was concluded that Theranekron was effective in healing tendons and reducing inflammation.

Keywords

Main Subjects

Biophysics & Radiotherapy

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Journal of Sabzevar University of Medical Sciences

Effect of Theranekron General Infusion on Tendon Repair in Rabbit by Ultrasonography and Histopathology

References

References

Volume 27, Issue 3
September and October 2020
Pages 483-491

Effect of Theranekron General Infusion on Tendon Repair in Rabbit by Ultrasonography and Histopathology

References

References

Volume 27, Issue 3September and October 2020Pages 483-491

Volume 27, Issue 3
September and October 2020
Pages 483-491