Authors
Abstract
Background and Purpose: Previous studies have not properly clarified the role of A2A adenosine receptors in convulsions induced by kindling. In the present study the role of these receptors in convulsions induced perforant path kindling has been investigated by blocking these receptors (with specific antagonists). Methods and Materials: This experimental study was conducted on 24 rats which were randomly divided into four groups of six. They were kindled by electric stimulation of the perforant path. In two groups before each kindling stimulation antagonists of A2A adenosine receptors (ZM 241385) (500 and 200 µM) was injected to the lateral ventricle of the rats. Control animals were given only the electric stimulations. In the fourth group (sham) the solvent of the abovementioned drug was injected to the lateral ventricle before kindling stimulations. The obtained data were analyzed using two-way ANOVA and Tukey tests. Results: Injecting the antagonists of A2A adenosine receptors (ZM 241385) (500 µM) to the lateral ventricle of the rats postponed the process of kindling. Two-way ANOVA indicated that number of stimulations required to reach the convulsive stages were significantly increased (P
Keywords
)