Calculation of the effective dose in the internal organs from 99mTc-Somatostatine analogue using MCNPX simulation code

Mahmoudi Mirhashemi, Mohsen; Shirmardi, Seyed Pezhman; Negarestani, Ali; Erfani, Mostafa

Document Type : Original Article

Authors

¹ Dept of Nuclear Engineering, Kerman graduate university, Iran

² Radiopharmaceuticals group, Radiation application research school

³ Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI)

Abstract

Introduction: Radiopharmaceuticals in nuclear medicine have several applications in medicine such as diagnostic and therapeutic.
Radiopharmaceuticals with gamma emitter radionuclides are used more in diagnostics. It is due to the low absorption of gamma gamma in the tissue relative to the particles of beta and alpha. The aim of this research is calculation of effective dose distribution in human body due to injection of 99mTc-Octrotide radiopharmaceuticals (Somatostatine analogue) in mice body.
Materials & methods: Effective dose in human body is estimated using MIRD (Medical Internal Radiation dose) phantom and MCNPX for different organs. Energy of gamma source and tally type are considered 140keV and F6 respectively.
Findings: Effective dose after injection of 99mTc- Octreotide is estimated by MCNPX simulation code. The adrenals and pancreas received the most effective dose relative to the other organs 6mSv/185MBq, 1.5 mSv/185MBq respectively.
Discussion and conclusion: The results showed that the adrenal and the pancreas are the organs of at risk in 99mTc-Octreotide radiopharmaceutical imaging.

Keywords

Main Subjects

Physiology & Pharmacology

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Journal of Sabzevar University of Medical Sciences

Calculation of the effective dose in the internal organs from 99mTc-Somatostatine analogue using MCNPX simulation code

References

References

Volume 26, Issue 1
March and April 2019
Pages 81-87

Calculation of the effective dose in the internal organs from 99mTc-Somatostatine analogue using MCNPX simulation code

References

References

Volume 26, Issue 1March and April 2019Pages 81-87

Volume 26, Issue 1
March and April 2019
Pages 81-87