Authors
Abstract
Background and Purpose: Magnesium deficiency has recently been proposed as a novel factor implicated in the pathogenesis of diabetes complications such as vascular disorders but the mechanism has not been completely clarified. The present study was designed to determine the effect of oral magnesium sulfate administration on skin microvascular blood flow in diabetic rats. Methods and Materials: In this experimental study 50 male Wister rats (200–250 g) were divided into two diabetic and one control groups. One diabetic group received magnesium sulfate (10 g/L) in drinking water for a 10-week period. The other two groups received only tap water. After 10 weeks animals were deeply anaesthetized and placed on a heating pad to maintain their body temperature at 37±0.5°C. Laser Doppler flow meter was used to measure the relative changes in skin blood flow. After stabilization we used ACh SNP L-NNA+ magnesium sulfate (0.1M) in control and experimental animal by microsyringe pump microinjection. In order to analyze the obtained data Student t-test and One-way ANOVA were used in SPSS with p
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