Document Type : Original Article
Authors
Abstract
Background and aim: Chronic kidney disease as an important risk factor associated with some disorders including hypertension and heart failure which is the major cause of death and disability in older people. Hence, the aim of the present study was to investigate the effects of two types aerobic exercise on levels of apelin and its receptor in the old rats heart tissue with chronic kidney disease
Methods and Materials: In this experimental study, 28 aged male wistar rats )48 to 50 weeks) were selected and randomly divided into 4 groups: control, doxorubicin, doxorubicin-30minutes training and doxorubicin-60 minutes training. Chronic kidney disease induced by a single subcutaneous injection of doxorubicin (8.5 mg kg). The swimming training program includes 3 times per week, 30 and 60 minutes for 8 weeks. The levels of apelin and its receptor in heart tissue measured by using ELISA method. one-way analysis of variance was used to analyze the data)p
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[1]. Jager KJ, Van Dijk PC, Dekker FW, Stengel B, Simpson K, Briggs JD. The epidemic of aging in renal replacement therapy: an update on elderly patients and their outcomes. Clinical Nephrology. 2003; 60: 352-360.
[2]. Apostolou T. Quality of life in the elderly patients on dialysis. International Urology & Nephrology. 2007; 39: 679-683.
[3]. Hellstrom Y, Persson G, Hallbery IR. Quality of life and symptoms among older people living at home. Journal of Advanced Nursing. 2004; 48: 584-593.
[4]. Johansen KL. Exercise and chronic kidney disease. Sports Medicine. 2005; 35(6): 485-499.
[5]. Lee VW, Harris DC. Adriamycin nephropathy: A model of focal segmental glomerulosclerosis. Nephrol. 2011; 16(1): 30-8.
[6]. Jeansson M, Björck K, Tenstad O, Haraldsson B. Adriamycin alters glomerular endothelium to induce proteinuria. J Am Soc Nephrol. 2009; 20(1): 114-22.
[7]. Venkatesan N, Punithavathi D, Arumugam V. Curcumin prevents adriamycin nephrotoxicity in rats. Br J Pharmacol. 2000; 129(2): 231-4.
[8]. Szokodi I, Tavi P, Foldes G, Voutilainen-Myllyla S, Ilves M, Tokola H, et al. Apelin, the novel end ogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circulation Research, 2002; 91(5): 434-440.
[9]. Chandrasekaran B, Dar O, McDonagh T. The role of apelin in cardiovascular function and heart failure. European Journal of Heart Failure. 2008; 10: 725-732.
[10].Castan-Laurell I, Dray C, Attané C, Duparc T, Knauf C, Valet P. Apelin diabetes, and obesity. Endocrine. 2011; 40: 1-9.
[11].Masari B, Knibiehler B, Audigier Y. Apelin signalling: a promising pathway from cloning to pharmacology cell. 2005; 17: 415-426.
[12].Charles CJ. Putative role for apelin in pressure/ volume homeostasis and cardiovascular disease. Cardiovascular & Hematological Agents in Medicinal Chemistry. 2007; 5: 1-10.
[13].Belabbas H, Zalvidea S, Casellas D, Molès JP, Galbes O, Mercier J, Jover B.Contrasting effect of exercise and angiotensin II hypertension on in vivo and in vitro cardiac angiogenesis in rats. AJP Regulatory Integrative and Comparative Physiology. 2008; 295(5): R1512-8.
[14].Mahmoodi AA, DabidiRoshan V, Gharakhanlou R, Hedayati M. Effects of exercise and ferula gummosa on apelin of cardiac and kidney tissues in L-NAME induced hypertension in rats. Iranian Journal of Health and Physical Activity. 2013; 4: 42-50. [in Persian]
[15].Zhang J, Ren CX, Qi YF, Lou LX, Chen L, Zhang LK, et al. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats. Life Sciences. 2006; 79: 1153-1159.
[16].Shaebine SH, Shemshaki A, Hanache P. The effect of exercise on Plyn reset plasma and blood pressure in women runners. Qom University of Medical Sciences .2012; 6: 3-27. [in Persian]
[17].Mohebe H, Rahmane neya F, Hedayati Amame MH, Saeidi T. The effect of 8 weeks aerobic exercise at moderate intensity levels of plasma apelin and insulin resistance in women with type 2 diabetes. Journal of Exercise Physiology. 2013; 20: 115-28. [in Persian]
[18].Minami N, Li Y, Guo Q, Kawamura T, Mori N, Nagasaka M, et al. Effects of angiotensinconverting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle. J Hypertens. 2007; 25: 1241-1248.
[19].Peng CC, Chen KC, Hsieh CL, Peng RY. Swimming exercise prevents fibrogenesis in chronic kidney disease by inhibiting the myofibroblast transdifferentiation. PLoS ONE. 2012; 7(6): e37388.
[20].Chen KC, Peng CC, Hsieh CL, Peng RY. Exercise ameliorates renal cell apoptosis in chronic kidney disease by intervening in the intrinsic and the extrinsic apoptotic pathways in a rat model. Evidence-Based Complementary and Alternative Medicine. 2013.
[21].Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R, et al. A novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Circulation. 2003; 108(12): 1432-1439.
[22].Kalea AZ, Batlle D. Apelin and ACE2 in cardiovascular disease, Curr Opin Investig Drugs. 2010; 11(3): 273-82.
[23].Modgil A, Guo L, O'Rourke ST, Sun C. Apelin-13 inhibits large-conductance Ca2+- mechanism. PLoS One. 2013; 8(12): e83051.
[24].Katugampola SD, Maguire JJ, Matthewson SR, Davenport AP. [(125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol. 2001; 132(6): 1255-60 activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent.
[25].Lee DK, Saldivia VR, Nguyen T, Cheng R, George SR, O'dowd FB. Modification of the terminal residue of apelin- 13 antagonises its hypotensive action. Endocrinology. 2004; 146: 231-236.
[26].Nakas-Icindic E, Hadzimuratovic A, Huskic J, Hadzovic A, Zaciragic A, Avdagic N. Serum activity of angiotensin converting enzyme and blood pressure response to acute dynamic exercise. Bosnian Journal of Basic Medical Sciences. 2004; 4(4): 32-36.
[27].Green DJ, Maiorana A, O'Driscoll G, Taylor R. Effect of exercise training on endothelium-derived nitric oxide function in humans. Journal of Physiology. 2004; 561(Pt 1): 1-25....
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