Document Type : Original Article
Authors
- vajiheh gharzi
- sahar kalate
- rahim akrami
- Mohammad Shurideh yazdi
- Maryam Latifnia
- Mojtaba Fattahi Abdizadeh
Department of Microbiology, Faculty of Medicine, SabzevarUniversity of Medical Sciences, Sabzevar, Iran
Abstract
Evaluation of immune response to HBV vaccine in the staff and students of Sabzevar University of Medical Sciences (2014-15)
Background:Hepatitis B is a bloodborne infections and it is predicted that about two billion people in the world have been exposed to the hepatitis B virus. Because of occupational reasons, medical students and staffs are more susceptible to expose to this disease than other members of society.
Materials and Methods:This study is a descriptive-analytic study and 238 staffs and students of Sabzevar University of Medical Sciences were randomly selected and sampled. Then, the antibody titer of surface anti-protein of hepatitis B virus (HBs- Ab) was measured using ELISA method and the results were analyzed using the software Stata 12 after recording the demographic results and information.
Results:Out of 238, 156 persons were female ( 65.5%) and 82 persons ( 34.5%) were male. 66% of individuals had antibody higher than 10 mu/ml and 37.4 % of individuals showed the appropriate answers higher than 100 u/ml. The relationship between job, sex and marital status with the immune response was significant. 100% of people who received full dose along with the booster vaccine were immune. Over time, the percentage of immune people has been decreased.
Conclusion:Considering the reduction of response to vaccines over time and healthcare personnel being at risk, it is recommended that antibody titer was periodically examined in these individuals in 5 to 10 years to administer a booster dose in the case of a decrease in antibody titers.
Keywords
Main Subjects
[2]. El-Serag HB. Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma. Gastroenterology. 2012; 142(6): 1264-73.e1.
[3]. Mittal S, El-Serag HB. Epidemiology of HCC: Consider the Population. Journal of clinical gastroenterology. 2013; 47(0): S2-S6.
[4]. Papastergiou V, Lombardi R, MacDonald D ,
Tsochatzis EA. Global Epidemiology of Hepatitis B Virus (HBV) Infection. Current Hepatology Reports. 2015; 14(3): 171-8.
[5]. Lavanchy D. Worldwide epidemiology of HBV infection, disease burden, and vaccine prevention. Journal of Clinical Virology. 2005; 34: S1-S3.
[6]. Mohammadi Z, Keshtkar A, Eghtesad S, Jeddian A, Pourfatholah AA, Maghsudlu M, et al. Epidemiological Profile of Hepatitis B Virus Infection in Iran in the Past 25 years; A Systematic Review and Meta-analysis of General Population Studies. MiddleEast journal of digestive diseases. 2016; 8(1): 5-18.
[7]. Salehi-Vaziri M, Sadeghi F, Almasi Hashiani A, Gholami Fesharaki M, Alavian SM. Hepatitis B Virus Infection in the General Population of Iran: An Updated Systematic Review and Meta-Analysis. Hepatitis monthly. 2016; 16(4): e35577.
[8]. La Torre G, Saulle R. Risk factors from HBV infection among blood donors: A systematic review. Asian Pacific Journal of Tropical Biomedicine. 2016; 6(4): 344-9.
[9].Shoaei P, Najafi S, Lotfi N, Vakili B, Ataei B, Yaran M, etal. Seroprevalence of hepatitis B virus infection and hepatitis B surface antibody status among laboratory health care workers in Isfahan, Iran. Asian Journal of Transfusion Science. 2015; 9(2): 138-40.
[10]. Ciorlia LAS, Zanetta DMT. Hepatitis B in healthcare workers: prevalence, vaccination and relation to occupational factors. Brazilian Journal of Infectious Diseases. 2005; 9: 384-9 .
[11]. Babanejad M, Izadi N, Najafi F, Alavian SM. The HBsAg Prevalence Among Blood Donors From Eastern Mediterranean and MiddleEastern Countries: A Systematic Review and Meta-Analysis. Hepatitis monthly. 2016; 16(3): e35664 .
[12]. Noh KW, Poland GA, Murray JA. Hepatitis B vaccine nonresponse and celiac disease. The American journal of gastroenterology. 2003; 98(10): 2289-92 .
[13]. MomeniN, Ahmad Akhoundi MS, Alavian SM, Shamshiri AR, Norouzi M, Mahboobi N, et al. HBV Vaccination Status and Response to Hepatitis B Vaccine Among Iranian Dentists, Correlation With Risk Factors and Preventive Measures. Hepatitis monthly. 2015; 15(1): e20014 .
[14]. Bagheri-Jamebozorgi M, Keshavarz J, Nemati M, Mohammadi-Hossainabad S, Rezayati MT, Nejad-Ghaderi M, et al. The persistence of anti-HBs antibody and anamnestic response 20 years after primary vaccination with recombinant hepatitis B vaccine at infancy . Human vaccines & immunotherapeutics. 2014; 10(12): 3731-6 .
[15]. Norouzirad R, Shakurnia AH, Assarehzadegan M-A, Serajian A, Khabazkhoob M. Serum Levels of Anti-Hepatitis B Surface Antibody Among Vaccinated Population Aged 1 to 18 Years in Ahvaz City Southwest of Iran. Hepatitis monthly. 2014; 14(1): e13625 .
[16]. Falah Khoshkholgh E, Mikailpour Ardabili B, Habibzadeh S, Amani F, Seyed Hashemi E, Mamlooki M, et al. Evaluation of Immune Response towards Hepatitis B Virus Vaccination among Vaccinated Students ofArdebil University of Medical Sciences in Iran. Infection, Epidemiology and Medicine. 2016; 2(4): 24-8
[17]. McMahon BJ, Dentinger CM, Bruden D, Zanis C, Peters H, Hurlburt D, et al. Antibody Levels and Protection after Hepatitis B Vaccine: Results of a 22-Year Follow-Up Study and Response to a Booster Dose. Journal of Infectious Diseases. 2009; 200(9): 1390-6 .
[18]. Lu C-Y, Ni Y-H, Chiang B-L, Chen P-J, Chang M-H, Chang L-Y, et al. Humoral and Cellular Immune Responses to a Hepatitis B Vaccine Booster 15–18 Years after Neonatal Immunization. Journal of Infectious Diseases. 2008; 197(10): 1419-26 .
[19]. Zhang L, Lyu J, Yan B, Liu J, Feng Y, Chen S, et al. [Anti-HBs persistence after revaccination with three doses of hepatitis B vaccines among non-responsive adults : 24 - month of follow-up]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2015; 49(9):782-7 .
[21]. Yan B, Lyu J, Liu J, Feng Y, Xu A, Chen S, et al. [Antibody persistence following booster vaccination with three doses of hepatitis B vaccines among low-response adults in Zhangqiu county of Shandong province: 24-month of follow-up from 2009]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]. 2014; 48(12): 1043-7.
[22]. Bagheri-Jamebozorgi M, Keshavarz J, Nemati M, Mohammadi-Hossainabad S, Rezayati M-T, Nejad-Ghaderi M, et al. The persistence of anti-HBs antibody and anamnestic response 20 years after primary vaccination with recombinant hepatitis B vaccine at infancy. Human vaccines & immunotherapeutics. 2014; 10(12): 37.6-31
[23]. Baba Mahmoodi F. Evaluation of Hepatitis B Antibody (HBS) Levels in Nursing Staff Of Gaemshahr Razi Hospital and it’s Variation With Duration Of Immunity Post HB Vaccination. Journal of Mazandaran University of Medical Sciences. 2000; 10(27): 48-5.3
[24]. Young KM, Gray CM, Bekker L-G. Is Obesity a Risk Factor for Vaccine Non-Responsiveness? PloS one. 2013; 8(12): e82779.
[25]. Hudu SA, Malik YA, Niazlin MT, Harmal NS, Adnan A, Alshrari AS, et al. Antibody and immune memory persistence post infant hepatitis B vaccination. Patient preference and adherence. 2013;7:981-6.
[26]. Elrashidy H, Elbahrawy A, El-Didamony G, Mostafa M, George NM, Elwassief A, et al. Antibody levels against hepatitis B virus after hepatitis B vaccination in Egyptian diabetic children and adolescents. Human vaccines & immunotherapeutics. 2013; 9(9): 2002-6.
[27]. Alavian SM, Izadi M, Zare AA, Lankarani MM, Assari S, Vardi MM. Survey of the level of anti-HBs antibody titer in vaccinated Iranian general dentists. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. 2008; 28(6): 265-70.
[28]. Azarkeivan A, Karimi G, Shaiegan M, Maghsudlu M, Tabbaroki A. Antibody titration and immune response of Iranian beta-thalassemic patients to hepatitis B virus vaccine (booster effect). Pediatric hematology and oncology. 2009; 26(4):195-201.
[29]. Jafarzadeh A, Montazerifar SJ. Persistence of anti-HBs antibody and immunological memory in children vaccinated with hepatitis B vaccine at birth. Journal of Ayub Medical College, Abbottabad : JAMC. 2006; 18(4): 4-9
)