Epidemiology and Statistics
ali akbarpoursohbatabadi; azam moslemi; fatemeh dorreh; mohamad rafiei
Volume 29, Issue 1 , May and June 2022, , Pages 51-64
Abstract
Background: Congenital Hypothyroidism is one of the most prevalence disease of endocrinology and metabolic infant and important caused of mental deficiency. Hypothyroidism in the secondary causes represented by problem in pituitary or hypothalamus and shortage of TSH . clinical symptom of Hypothyroidism ...
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Background: Congenital Hypothyroidism is one of the most prevalence disease of endocrinology and metabolic infant and important caused of mental deficiency. Hypothyroidism in the secondary causes represented by problem in pituitary or hypothalamus and shortage of TSH . clinical symptom of Hypothyroidism at the first days of birth are indiscernible so only way of diagnosis and treatment of that, is screening. In this study we used the bootstrap method to evaluation the ROC curve of diagnostic screening TSH test. Materials and Methods: in this study A bootstrap method is proposed to plot ROC curve and determinate the cut point of TSH & T4 based on YOUDEN method. at the first generated subsample and estimated ROC and cut-off point for each sample. the procedure run for 500 replicate. for each replicate selected cut-off where have maximum YOUDEN. The cut-off point calculated for 500 replications from each sample and then selected mean of 500 replicate. The cut-off which have minimum misclassification selected optimal cut-off point.Results: based ordinary method to estimate the ROC curve the optimal cut-off point for TSH variable is 10MU/L and for T4 variable is 100MU/DL which based the bootstrap method respectively optimal cut-off point for TSH is 9.54 and for T4 is 101.5.Conclusion: the optimal cut-off point where obtained from bootstrap method have minimum misclassification rate versus ordinary method. based the small sample bootstrap have minimum misclassification rate toward ordinary method with large sample.
MB ARDESHIR LARIJANI; SM TAVANGAR; AR SHAFAHI; A LASHKARI; M RASOULINEZHAD; R HESHMAT; M IZADI; V HAGHPANAH; SH AFHAMI; M MOHRAZ
Volume 13, Issue 4 , January and February 2007, , Pages 166-171
Abstract
Background and Purpose: A wide spectrum of endocrine abnormalities including thyroid dysfunction has been observed in HIV-infected patients with different results. This study was conducted to determine the frequency of thyroid dysfunction and to identify factors affecting the development of hypothyroidism ...
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Background and Purpose: A wide spectrum of endocrine abnormalities including thyroid dysfunction has been observed in HIV-infected patients with different results. This study was conducted to determine the frequency of thyroid dysfunction and to identify factors affecting the development of hypothyroidism in HIV-infected patients.
Methods and Materials: Free T4, FT3, TSH, and thyroglobulin levels of 88 HIV-infected patients receiving care at UT counseling center for Behavioral Disorders in Tehran, an out patient referral center, were measured and data on their age, sex, body weight, BMI, history of opium and injection addictions, duration of HIV infection, disease stage, history of opportunistic infection or malignancy, CD4 cell count, antiretroviral treatment with antiretroviral drugs (HAART), receipt of other drugs (TMP-SMX, antituberculosis drugs, and steroids), and hepatitis C virus Co-infection were collected. Inclusion of the subjects was simply random.
Results:17% of subjects had hypothyroidism; 1.1% had overt hypothyroidism; 2.3% subclinical hypothyroidism and 13.6% had low FT4 levels. The multivariate analysis showed that none of the studied factors were associated with the development of hypothyroidism.
Conclusion: As none of the above-mentioned factors are not associated with the development of hypothyroidism, hypothyroidism should be considered in HIV-infected patients.